2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. FOXJ

FOXJ

Forkhead Box J Protein

Forkhead box protein J (FOXJ) is a member of the Forkhead/winged helix (FOX) family of transcription factors. FOXJ members include FOXJ1, FOXJ2, and FOXJ3. FOXJ contains a conserved "Forkhead/winged-helix" domain for binding to specific DNA sequences and regulating gene expression. FOXJ is involved in respiratory, ventricular, and cancer applications[1].

FOXJ Isoform Specific Products:

FOXJ Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163982
    FOXJ1 agonist 1
    		Agonist
    FOXJ1 agonist 1 (compound 16c) is an orally effective small molecule that can effectively enhance the expression of FOXJ1. Foxj1-IN-1 acts on the mammalian airway system composed of multiciliated cells (MCC) to prevent the development and onset of chronic obstructive pulmonary disease (COPD). Foxj1-IN-1 can induce the production of motile cilia in the respiratory system of zebrafish and mammals, and inhibit elastase-induced COPD mouse models. Foxj1-IN-1 has good liver microsomal stability, in vivo PK curve and AUC; it has no significant inhibition of CYP and hERG, and does not have significant cytotoxicity.
    FOXJ1 agonist 1
FOXJ Isoform Comparison

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