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Results for "

adrenergic receptor agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (276) 5-HT Receptor (43) Adenosine Receptor (3) Adiponectin Receptor (1) Akt (10) AMPK (4) Antibiotic (3) Apoptosis (9) Arrestin (2) Autophagy (8) Bacterial (1) Biochemical Assay Reagents (1) Calcium Channel (3) Dopamine Receptor (19) Dopamine Transporter (5) Drug Derivative (1) Drug Intermediate (2) Drug Metabolite (5) Endogenous Metabolite (21) Environmental Pollutants (1) ERK (9) Fluorescent Dye (1) GABA Receptor (1) GPR109A (1) Histamine Receptor (5) iGluR (11) Imidazoline Receptor (6) Influenza Virus (2) Interleukin Related (5) Isotope-Labeled Compounds (44) LXR (2) mAChR (6) MAP3K (2) MDM-2/p53 (2) mGluR (1) MMP (5) Monoamine Oxidase (4) NF-κB (5) Opioid Receptor (5) Parasite (4) Phosphodiesterase (PDE) (1) PI3K (6) PKC (1) Potassium Channel (5) Reference Standards (57) Reverse Transcriptase (3) ROS Kinase (2) Serotonin Transporter (5) Serpin (1) Sigma Receptor (3) Sodium Channel (5) TNF Receptor (5) Trace Amine-associated Receptor (TAAR) (7) Trk Receptor (5) TRP Channel (2) Vasopressin Receptor (1) VEGFR (5)
By Research Areas:	Cancer (41) Cardiovascular Disease (100) Endocrinology (104) Infection (11) Inflammation/Immunology (82) Metabolic Disease (53) Neurological Disease (87)

By Targets:

Adrenergic Receptor (276)

5-HT Receptor (43)

Adenosine Receptor (3)

Adiponectin Receptor (1)

Akt (10)

AMPK (4)

Antibiotic (3)

Apoptosis (9)

Arrestin (2)

Autophagy (8)

Bacterial (1)

Biochemical Assay Reagents (1)

Calcium Channel (3)

Dopamine Receptor (19)

Dopamine Transporter (5)

Drug Derivative (1)

Drug Intermediate (2)

Drug Metabolite (5)

Endogenous Metabolite (21)

Environmental Pollutants (1)

ERK (9)

Fluorescent Dye (1)

GABA Receptor (1)

GPR109A (1)

Histamine Receptor (5)

iGluR (11)

Imidazoline Receptor (6)

Influenza Virus (2)

Interleukin Related (5)

Isotope-Labeled Compounds (44)

LXR (2)

mAChR (6)

MAP3K (2)

MDM-2/p53 (2)

mGluR (1)

MMP (5)

Monoamine Oxidase (4)

NF-κB (5)

Opioid Receptor (5)

Parasite (4)

Phosphodiesterase (PDE) (1)

PI3K (6)

PKC (1)

Potassium Channel (5)

Reference Standards (57)

Reverse Transcriptase (3)

ROS Kinase (2)

Serotonin Transporter (5)

Serpin (1)

Sigma Receptor (3)

Sodium Channel (5)

TNF Receptor (5)

Trace Amine-associated Receptor (TAAR) (7)

Trk Receptor (5)

TRP Channel (2)

Vasopressin Receptor (1)

VEGFR (5)

By Research Areas:

Cancer (41)

Cardiovascular Disease (100)

Endocrinology (104)

Infection (11)

Inflammation/Immunology (82)

Metabolic Disease (53)

Neurological Disease (87)

316

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Adrenergic Receptor

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-13715

Norepinephrine 60+ Cited Publications Levarterenol; L-Noradrenaline	Endogenous Metabolite Adrenergic Receptor Autophagy	Cardiovascular Disease Metabolic Disease Cancer
Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-13715A

Norepinephrine hydrochloride 60+ Cited Publications Levarterenol hydrochloride; L-Noradrenaline hydrochloride	Adrenergic Receptor Autophagy Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-B0225

Methyldopa 2 Publications Verification L-(-)-α-Methyldopa; MK-351	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B1276

Metaproterenol hemisulfate Metaproterenol sulfate	Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology
Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a *β2-adrenergic* receptor (β2AR)** agonist with an IC₅₀ of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity .

HY-N0166

Gramine 4 Publications Verification Donaxine	Adiponectin Receptor Reverse Transcriptase	Infection Metabolic Disease Endocrinology Cancer
Gramine (Donaxine) is an alkaloid, acts as an active *adiponectin receptor* (AdipoR)** agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse *β2-Adrenergic* receptor (β2-AR)** agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-B0802A

Terbutaline 1 Publications Verification	Drug Metabolite Adrenergic Receptor Antibiotic	Endocrinology
Terbutaline is an orally active β₂-adrenergic *receptor* agonist and an active metabolite of bambuterol . Terbutaline can be used in asthma symptom research .

HY-B0802

Terbutaline sulfate 1 Publications Verification Terbutaline hemisulfate	Adrenergic Receptor Antibiotic	Endocrinology
Terbutaline sulfate is an orally active β₂-adrenergic *receptor* agonist and an active metabolite of bambuterol . Terbutaline sulfate can be used in asthma symptom research .

HY-B1270

Isoxsuprine hydrochloride	Adrenergic Receptor iGluR	Neurological Disease Endocrinology
Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with K_is of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.

HY-B0225B

Methyldopa hydrate 2 Publications Verification L-(-)-α-Methyldopa hydrate; MK-351 hydrate	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0659

Brimonidine 5+ Cited Publications UK 14304; AGN190342	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B0659A

Brimonidine tartrate 5+ Cited Publications UK 14304 tartrate; AGN190342 tartrate	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Brimonidine tartrate (UK 14304 tartrate) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B1052

Lofexidine hydrochloride Baq-168; MDL-14042	Adrenergic Receptor Imidazoline Receptor	Neurological Disease Metabolic Disease
Lofexidine hydrochloride (Baq-168) is an orally active agonist of the imidazoline I1 receptor (imidazoline I1 receptor) (Ki: 1.9 nM) and α₂-adrenergic receptor (α2-adrenergic *receptor). Lofexidine hydrochloride binds to the α₂A-adrenergic* receptor, reduces sympathetic outflow, lowers blood pressure, and exhibits vasoconstrictive effects. Lofexidine hydrochloride regulates the expression of c-fos and alleviates opioid withdrawal symptoms. Lofexidine hydrochloride is applicable to research on opioid addiction and withdrawal .

HY-59132

2-Amino-1-phenylethanol	Drug Intermediate	Others
2-Amino-1-phenylethanol is a pharmaceutical intermediate that can be used for the synthesis of antimalarial agents and β₂-adrenergic receptor agonists .

HY-B1675A

Levalbuterol hydrochloride (R)-Albuterol hydrochloride; (R)-Salbutamol hydrochloride; Levosalbutamol hydrochloride	Adrenergic Receptor	Inflammation/Immunology
Levalbuterol ((R)-Albuterol) hydrochloride is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol hydrochloride is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD .

HY-U00205

Dopexamine hydrochloride FPL60278AR	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Dopexamine hydrochloride is a β2 adrenergic receptor agonist.

HY-B1052A

Lofexidine Baq-168 free base; MDL-14042 free base	Imidazoline Receptor Adrenergic Receptor	Neurological Disease Metabolic Disease
Lofexidine (Baq-168 free base) is an orally active agonist of the imidazoline I1 receptor (imidazoline I1 receptor) (Ki: 1.9 nM) and α₂-adrenergic receptor (α2-adrenergic *receptor). Lofexidine binds to the α₂A-adrenergic* receptor, reduces sympathetic outflow, lowers blood pressure, and exhibits vasoconstrictive effects. Lofexidine regulates the expression of c-fos and alleviates opioid withdrawal symptoms. Lofexidine is applicable to research on opioid addiction and withdrawal .

HY-Z6449

Phenylephrone hydrochloride	Adrenergic Receptor	Neurological Disease
Phenylephrine hydrochlorid is an α1-adrenergic receptor agonist. As a sympathomimetic agent, Phenylephrine hydrochlorid exerts similar effects to epinephrine and ephedrine. Phenylephrine hydrochlorid induces vasoconstriction and increases perfusion pressure .

HY-B1116

Metaraminol tartrate Metaradrine tartrate	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Metaraminol tartrate?(Metaradrine tartrate) is an *α-adrenergic* agonist . Metaraminol tartrate is a sympathomimetic amine that directly and indirectly affects adrenergic receptors, with alpha effects being predominant.Metaraminol tartrate acts as a vasopressor agent .

HY-B1696

Methyldopate	Adrenergic Receptor	Cardiovascular Disease
Methyldopate is an ethyl ester proagent of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate has the potential for severe hypertension research .

HY-B1347

Clorprenaline hydrochloride	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Clorprenaline hydrochloride is a **β₂-adrenergic receptor** agonist that is implicated in bronchial expansion. Clorprenaline has the potential for asthma research .

HY-B1694A

Methoxyphenamine hydrochloride NSC-65644	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Methoxyphenamine hydrochloride, a non-regulated analog of Methamphetamine, is a β-adrenergic receptor agonist used as a bronchodilator .

HY-B1615S

Clenbuterol-d9 NAB-365-d₉	Adrenergic Receptor	Inflammation/Immunology
Clenbuterol-d₉ is the deuterium labeled Clenbuterol. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC₅₀ of 31.9 nM .

HY-16413

Protokylol hydrochloride Caytine hydrochloride; JB-251 hydrochloride	TRP Channel Adrenergic Receptor	Others
Protokylol hydrochloride (Caytine hydrochloride; JB-251 hydrochloride) is the hydrochloride salt form of Protokylol (HY-114630). Protokylol hydrochloride is an agonist for β2-adrenergic receptor and TRPV1. Protokylol hydrochloride exhibits activity as a bronchodilator .

HY-12463A

Carmoterol	Adrenergic Receptor	Inflammation/Immunology
Carmoterol is a highly potent and selective long-acting β2-adrenergic receptor agonist with a pEC₅₀ of 10.19. Carmoterol shows 53-fold higher affinity for β2-adrenergic receptors than for β1-adrenergic receptors. Carmoterol stimulates cyclic adenosine monophosphate accumulation, induces airway smooth muscle relaxation, inhibits bronchoconstriction, reduces thromboxane B₂ release, and prolongs survival time. Carmoterol can be used in research related to asthma and chronic obstructive pulmonary disease (COPD) .

HY-119985

Broxaterol Z 1170	Adrenergic Receptor	Others
Broxaterol (Z 1170) is the an agonist of β₂ adrenergic receptor that affects the smooth muscle receptors in the body. Broxaterol plays an important role in respiratory disease .

HY-13713

LY377604	Adrenergic Receptor	Metabolic Disease Endocrinology
LY377604 is a human β₃-adrenergic receptor agonist with an EC₅₀ of 2.4 nM and also a β₁- and β₂-adrenergic *receptor* antagonist.

HY-W702712

3-Hydroxy xylazine	Adrenergic Receptor	Neurological Disease
3-Hydroxy xylazine is a metabolite of the α2-adrenergic receptor agonist Xylazine.

HY-112071

Prenalterol	Adrenergic Receptor	Cardiovascular Disease
Prenalterol is a selective β1-adrenergic receptor agonist. Prenalterol has no effect on gut smooth muscle contractile activity. Prenalterol can be used for researching cardiovascular disease .

HY-B1276A

Metaproterenol Orciprenaline	Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology
Metaproterenol (Orciprenaline) is a direct-acting sympathomimetic and a *β2-adrenergic* receptor (β2AR)** agonist with an IC₅₀ of 68 nM. Metaproterenol also has anti-inflammatory activity .

HY-107847

2-(2-Methoxyphenoxy)ethylamine hydrochloride	5-HT Receptor Adrenergic Receptor	Neurological Disease
2-(2-Methoxyphenoxy)ethylamine hydrochloride (Compound 2b) is a mixed agonist/antagonist. 2-(2-Methoxyphenoxy)ethylamine hydrochloride is a5-HT1A receptor partial agonist and a α1-adrenergic receptor antagonist. 2-(2-Methoxyphenoxy)ethylamine hydrochloride can be used for neurological diseases research, such as anxiety, depression and psychosis .

HY-W009456

Adrenergic a2C receptor agonist-1	Adrenergic Receptor	Endocrinology
Adrenergic a2C receptor agonist-1 (compound 13) is an agonist targeting the adrenergic receptor a2C .

HY-131145

Brombuterol hydrochloride Bromobuterol hydrochloride	Adrenergic Receptor	Inflammation/Immunology
Brombuterol hydrochloride (Bromobuterol hydrochloride) is a β-adrenergic receptor agonist .

HY-19057

Vatinoxan 2 Publications Verification MK-467; L-659066	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Vatinoxan (MK-467) is an alpha 2-adrenergic receptor antagonist. The peripheral selectivity of Vatinoxan determines that it has limited penetration across the blood-brain barrier and therefore has low concentrations in the central nervous system. Vatinoxan antagonizes alpha 2-adrenergic receptor receptors by binding to them, thereby reducing or preventing cardiovascular effects caused by α2-adrenergic agonists. Vatinoxan can be used in studies of cardiovascular effects, sedation and analgesia .

HY-14298

Milveterol hydrochloride GSK-159797C	Adrenergic Receptor	Endocrinology
Milveterol hydrochloride is a long-acting β2-adrenergic receptor agonist. Milveterol hydrochloride can be used in study asthma and chronic obstructive pulmonary disease (COPD) .

HY-B0225A

Methyldopa hydrochloride L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-119456A

Romifidine hydrochloride	Adrenergic Receptor	Neurological Disease
Romifidine hydrochloride is an α₂ adrenergic receptor agonist. Romifidine hydrochloride shows sedation effects in vivo .

HY-B0659S

Brimonidine-d4	Adrenergic Receptor	Endocrinology
Brimonidine-d₄ is the deuterium labeled Brimonidine. Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B1696A

Methyldopate hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Methyldopate hydrochloride is an ethyl ester hydrochloride proagent of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate hydrochloride has the potential for severe hypertension research .

HY-B1675

Levalbuterol (R)-Albuterol; (R)-Salbutamol; Levosalbutamol	Adrenergic Receptor	Inflammation/Immunology
Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic *receptor* agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD .

HY-122440

Scopoline	Drug Metabolite Adrenergic Receptor	Others
Scopoline (compound 3a) is a compound formed from Scopine (HY-B0459), an α1 adrenergic receptor agonist .

HY-B1052S

Lofexidine-d4 hydrochloride Baq-168-d₄; MDL-14042-d₄	Isotope-Labeled Compounds Imidazoline Receptor Adrenergic Receptor	Neurological Disease Metabolic Disease
Lofexidine-d₄ hydrochloride (Baq-168-d₄) is the deuterium labeled Lofexidine hydrochloride (HY-B1052). Lofexidine hydrochloride (Baq-168) is an orally active agonist of the imidazoline I1 receptor (imidazoline I1 receptor) (Ki: 1.9 nM) and α₂-adrenergic receptor (α2-adrenergic *receptor). Lofexidine hydrochloride binds to the α₂A-adrenergic* receptor, reduces sympathetic outflow, lowers blood pressure, and exhibits vasoconstrictive effects. Lofexidine hydrochloride regulates the expression of c-fos and alleviates opioid withdrawal symptoms. Lofexidine hydrochloride is applicable to research on opioid addiction and withdrawal .

HY-114732

Procaterol	Adrenergic Receptor	Others
Procaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes .

HY-106562

Dopexamine FPL 60278	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Dopexamine is a β2 adrenergic receptor agonist.

HY-U00293

ZK-90055 hydrochloride	Adrenergic Receptor	Inflammation/Immunology Endocrinology
ZK-90055 hydrochloride is a β2 adrenergic receptor agonist.

HY-B1694

Methoxyphenamine NSC-65644 free base	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Methoxyphenamine is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.

HY-114630

Protokylol Caytine; JB-251	TRP Channel Adrenergic Receptor	Cardiovascular Disease
Protokylol (Caytine; JB-251) is a beta-adrenergic receptor agonist and TRPV1 agonist. Protokylol is used as a bronchodilator .

HY-129697

3-Hydroxy Medetomidine 3-OH Medetomidine; Medetomidine metabolite MIII	Drug Metabolite	Metabolic Disease
3-Hydroxy Medetomidine (3-OH Medetomidine; Medetomidine metabolite MIII) is a metabolite of the α2-adrenergic receptor agonist medetomidine.

HY-119456

Romifidine	Adrenergic Receptor	Neurological Disease
Romifidine is an α₂ adrenergic receptor agonist. Romifidine shows sedation effects in vivo .

HY-131104AS

Brombuterol-d9 hydrochloride Bromobuterol D9 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Inflammation/Immunology
Brombuterol-d₉ (hydrochloride) is a deuterium labeled Brombuterol hydrochloride. Brombuterol hydrochloride is a β-adrenergic receptor agonist .

HY-117406

Clencyclohexerol	Adrenergic Receptor	Metabolic Disease
Clencyclohexerol is a β2 adrenergic receptor agonist. Clencyclohexerol can be used as a growth promoter in animals .

Cat. No.	Nombre del producto	Type

HY-A0144A

Etilefrine hydrochloride

Biochemical Assay Reagents

Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

HY-A0144AR

Etilefrine hydrochloride (Standard)

Biochemical Assay Reagents

Etilefrine hydrochloride (Standard) is the analytical standard of Etilefrine hydrochloride (HY-A0144A). This product is intended for research and analytical applications. Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

Cat. No.	Nombre del producto	Target	Research Area

HY-P10336

Serpinin	Serpin	Neurological Disease Endocrinology
Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function . Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects .

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-B0468

Isoprenaline hydrochloride Maximum Cited Publications 87 Publications Verification Isoproterenol hydrochloride	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-13715

Norepinephrine 60+ Cited Publications Levarterenol; L-Noradrenaline	Cardiovascular Disease Structural Classification Classification of Application Fields Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite Adrenergic Receptor Autophagy
Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-13715A

Norepinephrine hydrochloride 60+ Cited Publications Levarterenol hydrochloride; L-Noradrenaline hydrochloride	Cardiovascular Disease Alkaloids Classification of Application Fields Mimosa pudica Linn. Leguminosae Other Alkaloids Phenols Polyphenols Plants Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Autophagy Endogenous Metabolite
Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-13715B

Norepinephrine bitartrate monohydrate 60+ Cited Publications Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate	Structural Classification Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Autophagy Endogenous Metabolite
Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-B0225

Methyldopa 2 Publications Verification L-(-)-α-Methyldopa; MK-351	Classification of Application Fields Ketones, Aldehydes, Acids Hippocastanaceae Aesculus hippocastanum Plants Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-N2037

Higenamine 5+ Cited Publications Norcoclaurine; Demethyl-Coclaurine	Alkaloids Structural Classification Classification of Application Fields Ranunculaceae Phenols Polyphenols Aconitum carmichaeli Debx. Plants Isoquinoline Alkaloids Disease Research Fields Endocrinology Source Classification	MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis
Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC₅₀=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .

HY-N0166

Gramine 4 Publications Verification Donaxine	Infection Alkaloids Structural Classification Classification of Application Fields Gramineae Metabolic Disease Plants Disease Research Fields Arundo donax Linn. Endocrinology Indole Alkaloids Source Classification	Adiponectin Receptor Reverse Transcriptase
Gramine (Donaxine) is an alkaloid, acts as an active *adiponectin receptor* (AdipoR)** agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse *β2-Adrenergic* receptor (β2-AR)** agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-108353

Isoprenaline Maximum Cited Publications 87 Publications Verification	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
Isoprenaline is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B0225B

Methyldopa hydrate 2 Publications Verification L-(-)-α-Methyldopa hydrate; MK-351 hydrate	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-13715C

Norepinephrine tartrate 60+ Cited Publications Levarterenol tartrate; L-Noradrenaline tartrate	Cardiovascular Disease Structural Classification Classification of Application Fields Phenols Polyphenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Adrenergic Receptor Autophagy
Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates α₁, α₂, β₁ receptors .

HY-59132

2-Amino-1-phenylethanol	Structural Classification Productos naturales Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate
2-Amino-1-phenylethanol is a pharmaceutical intermediate that can be used for the synthesis of antimalarial agents and β₂-adrenergic receptor agonists .

HY-A0066A

Tolazoline hydrochloride Imidaline hydrochloride; NSC35110 hydrochloride	Alkaloids Classification of Application Fields Other Alkaloids Alpinia officinarum Hance Plants Disease Research Fields Endocrinology Source Classification Zingiberaceae	Adrenergic Receptor
Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α₂-adrenergic receptor agonist-related poisoning, and skin vascular disease research .

HY-13715R

Norepinephrine (Standard) Levarterenol (Standard); L-Noradrenaline (Standard)	Phenols Polyphenols Endogenous metabolite	Reference Standards Endogenous Metabolite Adrenergic Receptor Autophagy
Norepinephrine (Standard) is the analytical standard of Norepinephrine. This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-N0166R

Gramine (Standard) 4 Publications Verification Donaxine (Standard)	Infection Alkaloids Classification of Application Fields Gramineae Metabolic Disease Plants Disease Research Fields Arundo donax Linn. Endocrinology Source Classification	Reference Standards Adrenergic Receptor Reverse Transcriptase
Gramine (Standard) is the analytical standard of Gramine. This product is intended for research and analytical applications. Gramine (Donaxine) is an alkaloid, acts as an active *adiponectin receptor* (AdipoR)** agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse *β2-Adrenergic* receptor (β2-AR)** agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-13715AR

Norepinephrine hydrochloride (Standard) Levarterenol hydrochloride (Standard); L-Noradrenaline hydrochloride (Standard)	Alkaloids Mimosa pudica Linn. Leguminosae Other Alkaloids Phenols Polyphenols Plants Source Classification	Reference Standards Adrenergic Receptor Autophagy Endogenous Metabolite
Norepinephrine (hydrochloride) (Standard) is the analytical standard of Norepinephrine (hydrochloride). This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors[1][2][3][4].

HY-108353A

Isoprenaline hemisulfate Maximum Cited Publications 87 Publications Verification	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
Isoprenaline hemisulfate is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-135525

Agroclavine	Infection Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Indole Alkaloids Source Classification Cancer	Dopamine Receptor Adrenergic Receptor
Agroclavine acts as an agonist of the D1-dopamine receptor and **α₁-adrenergic receptor**. Agroclavine enhances the sensitivity of the brain to magnetic fields; it impairs spatial memory without affecting hippocampal long-term potentiation (LTP). Agroclavine exerts bidirectional regulatory effects on immune activity: it enhances NK cell activity with low toxicity under normal conditions, while it inhibits NK cell activity and exhibits significant cardiac and hepatic toxicity under stress conditions. Agroclavine can be used for research on neuroelectrophysiology, learning and memory, and immunoregulation .

HY-B0225A

Methyldopa hydrochloride L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-122440

Scopoline	Plants Source Classification	Drug Metabolite Adrenergic Receptor
Scopoline (compound 3a) is a compound formed from Scopine (HY-B0459), an α1 adrenergic receptor agonist .

HY-13715BR

Norepinephrine bitartrate monohydrate (Standard) Levarterenol bitartrate monohydrate (Standard); L-Noradrenaline bitartrate monohydrate (Standard)	Structural Classification Phenols Endogenous metabolite Source Classification	Reference Standards Adrenergic Receptor Autophagy Endogenous Metabolite
Norepinephrine (bitartrate monohydrate) (Standard) is the analytical standard of Norepinephrine (bitartrate monohydrate). This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors .

HY-B0468R

Isoprenaline hydrochloride (Standard) Isoproterenol hydrochloride (Standard)	Structural Classification Alkaloids Other Alkaloids Phenols Polyphenols Endogenous metabolite Source Classification	Reference Standards Adrenergic Receptor Endogenous Metabolite
Isoprenaline (hydrochloride) (Standard) is the analytical standard of Isoprenaline (hydrochloride). This product is intended for research and analytical applications. Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-N2037R

Higenamine (Standard) Norcoclaurine (Standard); Demethyl-Coclaurine (Standard)	Alkaloids Structural Classification Ranunculaceae Phenols Polyphenols Aconitum carmichaeli Debx. Plants Isoquinoline Alkaloids Source Classification	Reference Standards MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis
Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .

HY-50290A

Meluadrine tartrate	Monophenols Classification of Application Fields Other Diseases Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Adrenergic Receptor
Meluadrine tartrate is a potent agonist of β2 **adrenergic receptor** .

HY-50290

Meluadrine	Monophenols Classification of Application Fields Other Diseases Phenols Endogenous metabolite Disease Research Fields Source Classification	Adrenergic Receptor Endogenous Metabolite
Meluadrine is a potent agonist of β2 **adrenergic receptor**. Meluadrine is one of the metabolites of Tulobuterol (HY-B1810) .

HY-113320R

Etiocholanolone (Standard) 5β-Androsterone (Standard)	Structural Classification Microorganisms Endogenous metabolite Steroids Source Classification	Reference Standards GABA Receptor Endogenous Metabolite
Cimbuterol (Standard) is the analytical standard of Cimbuterol. This product is intended for research and analytical applications. Cimbuterol is a β-adrenergic receptor agonist .

HY-B0225BR

Methyldopa hydrate (Standard) L-(-)-α-Methyldopa hydrate (Standard); MK-351 hydrate (Standard)	Structural Classification Alkaloids Other Alkaloids Phenols Polyphenols Endogenous metabolite Source Classification	Reference Standards Adrenergic Receptor Endogenous Metabolite
Methyldopa (hydrate) (Standard) is the analytical standard of Methyldopa (hydrate). This product is intended for research and analytical applications. Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-101078A

(±)-Epibatidine dihydrochloride CMI 545 dihydrochloride	Alkaloids Structural Classification Animals Pyridine Alkaloids Source Classification	Dopamine Receptor
(±)-Epibatidine (CMI 545) dihydrochloride is an agonist of nicotinic with potent analgetic activity. (±)-Epibatidine (CMI 545) dihydrochloride is an alkaloid originally characterized from frog skin. (±)-Epibatidine (CMI 545) dihydrochloride have little or no activity at a variety of other central receptors, including opioid receptors, muscarinic receptors, adrenergic receptors, dopamine receptors, serotonin receptors, and gamma-aminobutyric acid receptors .

HY-A0066AR

Tolazoline hydrochloride (Standard) Imidaline hydrochloride (Standard); NSC35110 hydrochloride (Standard)	Alkaloids Other Alkaloids Alpinia officinarum Hance Plants Source Classification Zingiberaceae	Reference Standards Adrenergic Receptor
Tolazoline (hydrochloride) (Standard) is the analytical standard of Tolazoline hydrochloride (HY-A0066A). This product is intended for research and analytical applications. Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α₂-adrenergic receptor agonist-related poisoning, and skin vascular disease research .

HY-59132R

2-Amino-1-phenylethanol (Standard)	Structural Classification Productos naturales Endogenous metabolite Source Classification	Reference Standards Drug Intermediate
2-Amino-1-phenylethanol (Standard) is the analytical standard of 2-Amino-1-phenylethanol. This product is intended for research and analytical applications. 2-Amino-1-phenylethanol is a pharmaceutical intermediate that can be used for the synthesis of antimalarial agents and β₂-adrenergic receptor agonists.

HY-W015546R

β-N-methylamino-L-alanine hydrochloride (Standard) BMAA hydrochloride (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial Reference Standards mGluR PKC
Clenbuterol (Standard) is the analytical standard of Clenbuterol. This product is intended for research and analytical applications. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM . Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator .

Cat. No.	Nombre del producto	Chemical Structure

HY-B1037S2

Salbutamol-d9

Salbutamol-d₉ (Albuterol-d₉) is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .

HY-B1037S

Salbutamol-d3

Salbutamol-d₃ (Albuterol-d₃) is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .

HY-B1615S

Clenbuterol-d9
Clenbuterol-d₉ is the deuterium labeled Clenbuterol. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC₅₀ of 31.9 nM .

HY-B1111S1

Amitraz-d3
Amitraz-d₃ is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

HY-B0527AS

Amitriptyline-d6 hydrochloride

Amitriptyline-d₆ hydrochloride is the deuterium labeled Amitriptyline hydrochloride (HY-B0527A). Amitriptyline hydrochloride is an orally active tricyclic antidepressant (TCA). Amitriptyline hydrochloride mainly exerts its antidepressant effect by blocking SERT (K_i = 3.45 nM) and NET (K_i = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. Amitriptyline hydrochloride is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis). Amitriptyline hydrochloride can reduce inflammation, angiogenesis and fibrosis. Amitriptyline hydrochloride binds to DAT (with K_i = 2.58 μM). Amitriptyline hydrochloride has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) (K_i = 11-24 nM), H1 receptors (K_i = 0.5-1.1 nM), adrenergic α1 receptors (K_i = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline hydrochloride can block sodium channels and hERG potassium channel (IC₅₀ = 4.78 μM) and it has cardiotoxicity.

HY-B0659S

Brimonidine-d4
Brimonidine-d₄ is the deuterium labeled Brimonidine. Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B1052S

Lofexidine-d4 hydrochloride

Lofexidine-d₄ hydrochloride (Baq-168-d₄) is the deuterium labeled Lofexidine hydrochloride (HY-B1052). Lofexidine hydrochloride (Baq-168) is an orally active agonist of the imidazoline I1 receptor (imidazoline I1 receptor) (Ki: 1.9 nM) and α₂-adrenergic receptor (α2-adrenergic receptor). Lofexidine hydrochloride binds to the α₂A-adrenergic receptor, reduces sympathetic outflow, lowers blood pressure, and exhibits vasoconstrictive effects. Lofexidine hydrochloride regulates the expression of c-fos and alleviates opioid withdrawal symptoms. Lofexidine hydrochloride is applicable to research on opioid addiction and withdrawal .

HY-13715S

(Rac)-Norepinephrine-d3 formate
(Rac)-Norepinephrine-d₃ (formate) is deuterium labeled Norepinephrine. Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors .

HY-B0010AS

Formoterol-d3
Formoterol-d₃ is deuterium labeled Arformoterol. Arformoterol ((R,R)-Formoterol), the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol can be used for the research of chronic obstructive pulmonary disease (COPD) .

HY-12749AS

Midodrine-d6 hydrochloride
Midodrine-d₆ (hydrochloride) is a selective and orally active adrenergic *α1-receptor* agonist. Midodrine-d₆ (hydrochloride) can strengthen vascular contraction. Midodrine-d₆ (hydrochloride) can be used for the researches of cardiovascular disease, such as orthostatic hypotension .

HY-B1037S3

Salbutamol-d9 acetate

Salbutamol-d₉ (Albuterol-d₉) acetate is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .

HY-131104AS

Brombuterol-d9 hydrochloride
Brombuterol-d₉ (hydrochloride) is a deuterium labeled Brombuterol hydrochloride. Brombuterol hydrochloride is a β-adrenergic receptor agonist .

HY-15394S

(Rac)-Rotigotine-d7 (hydrochloride)

(Rac)-Rotigotine-d₇ (hydrochloride) is deuterium labeled (Rac)-Rotigotine (hydrochloride). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-A0007S

Rotigotine-d7 hydrochloride

Rotigotine-d₇ (N-0923-d₇) hydrochloride is the deuterium labeled Rotigotine(HY-75502). Rotigotine is a potent dopamine receptor agonist with K_i values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research.

HY-B1111S

Amitraz-d6
Amitraz-d6 (BTS-27419-d6) is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

HY-14300AS

Vilanterol-d4 trifenatate

Vilanterol-d₄ (trifenatate) is deuterium labeled Vilanterol (trifenatate).Vilanterol (GW642444) acetate is a long-acting β₂ adrenergic receptor agonist. Vilanterol acetate has pEC₅₀ values for β₂-AR, β₁-AR, and β₃-AR of 9.4, 6.4, and 6.1, respectively. Vilanterol acetate selectively activates airway β₂ adrenergic receptors, increases cAMP and thus relaxes bronchial smooth muscle. Vilanterol acetate can be used in asthma research.

HY-90003S

Tianeptine-d12

Tianeptine-d₁₂ is a deuterated analog of Tianeptine (HY-90003).Tianeptine is an atypical antidepressant. Tianeptine is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR). Tianeptine is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. Tianeptine increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects.

HY-B1421S

Ractopamine-d6 hydrochloride

Ractopamine-d₆ (LY031537-d₆) hydrochloride is the deuterium labeled Ractopamine hydrochloride (HY-B1421). Ractopamine (LY031537) hydrochloride is a potent β-adrenergic receptor (βAR) agonist with K_d values of ~25 nM for pig β₁AR and β₂AR. Ractopamine hydrochloride is linked to protein metabolism. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-13338S

Mabuterol-d9
Mabuterol-d₉ is a deuterium labeled Mabuterol. Mabuterol is an agonist of the β2-adrenergic receptor .

HY-B1270S

Isoxsuprine-d6 hydrochloride
Isoxsuprine-d₆ (hydrochloride) is the deuterium labeled Isoxsuprine hydrochloride. Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.

HY-131104S

Brombuterol-d9
Brombuterol-d₉ is a deuterium labeled Brombuterol. Brombuterol is a β-adrenergic receptor agonist .

HY-131106S

Clorprenaline-d7
Clorprenaline-d₇ is a deuterium labeled Clorprenaline. Clorprenaline is a β2-adrenergic receptor agonist that is implicated in bronchial expansion. Clorprenaline has the potential for asthma research .

HY-B0225AS

Methyldopa-d3 hydrochloride
Methyldopa-d₃ (hydrochloride) is deuterium labeled Methyldopa (hydrochloride). Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0452S1

Ritodrine-d3 hydrochloride
Ritodrine-d₃ (hydrochloride) is the deuterium labeled Ritodrine (hydrochloride). Ritodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist.

HY-17034BS

Medetomidine-d3 hydrochloride
Medetomidine-d₃ (hydrochloride) is the deuterium labeled Medetomidine hydrochloride. Medetomidine hydrochloride is an agonist of adrenergic alpha-2 receptor .

HY-W753523

Clorprenaline-d7 hydrochloride
Clorprenaline-d₇ hydrochloride is the deuterium labeled Clorprenaline hydrochloride (HY-B1347). Clorprenaline hydrochloride is a β2-adrenergic receptor agonist that is implicated in bronchial expansion. Clorprenaline has the potential for asthma research .

HY-B1052S1

Lofexidine-d4

Lofexidine-d₄ (Baq-168 free base-d₄) is deuterium labeled Lofexidine (HY-B1052A). Lofexidine (Baq-168 free base) is an orally active agonist of the imidazoline I1 receptor (imidazoline I1 receptor) (Ki: 1.9 nM) and α₂-adrenergic receptor (α2-adrenergic receptor). Lofexidine binds to the α₂A-adrenergic receptor, reduces sympathetic outflow, lowers blood pressure, and exhibits vasoconstrictive effects. Lofexidine regulates the expression of c-fos and alleviates opioid withdrawal symptoms. Lofexidine is applicable to research on opioid addiction and withdrawal .

HY-W705539

DL-Phenylephrine-d3 hydrochloride
DL-Phenylephrine-d₃ hydrochloride ((±)-Phenylephrine-d₃ hydrochloride) is the deuterium labeled DL-Phenylephrine hydrochloride (HY-W014726). DL-Phenylephrine ((±)-Phenylephrine) hydrochloride is a selective agonist of the alpha1-adrenergic receptor, exhibiting potent vasoconstrictive activity.

HY-W741999

Metaproterenol-d7-1 hemisulfate
Metaproterenol-d₇-1 (hemisulfate) is deuterium labeled Metaproterenol (hemisulfate). Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a *β2-adrenergic* receptor (β2AR)** agonist with an IC₅₀ of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity .

HY-B1276S

Metaproterenol-d7 hemisulfate
Metaproterenol-d₇ (hemisulfate) is the deuterium labeled Metaproterenol hemisulfate. Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC₅₀ of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity .

HY-15394S1

(Rac)-Rotigotine-d3 hydrochloride

(Rac)-Rotigotine-d₃ hydrochloride is a deuterium labeled (Rac)-Rotigotine (hydrochloride) (HY-15394). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_is of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-32329S

Setiptiline-d3

Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine .

HY-19436S

Solabegron-d8
Solabegron-d₈ (GW 427353-d₈) is deuterium labeled Solabegron. Solabegron (GW 427353) is a selective **β₃-adrenergic receptor** agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β₃-AR, with an EC₅₀ value of 22 nM . Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome .

HY-B0468S

Isoprenaline-d7 hydrochloride
Isoprenaline-d7 (hydrochloride) is a deuterated labeled Isoprenaline (hydrochloride) . Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B0475S

Xylometazoline-d4 hydrochloride
Xylometazoline-d₄ hydrochloride is deuterated labeled Xylometazoline hydrochloride (HY-B0475). Xylometazoline hydrochloride is an α-adrenergic receptor agonist (K_i=0.05-1.7 μM). Xylometazoline hydrochloride can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research .

HY-144224S

Tianeptine-d6 hydrochloride

Tianeptine-d₆ hydrochloride is the deuterium labeled Tianeptine hydrochloride. Tianeptine hydrochloride is an atypical antidepressant. Tianeptine hydrochloride is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR). Tianeptine hydrochloride is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. Tianeptine hydrochloride increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine hydrochloride exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine hydrochloride inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine hydrochloride can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects.

HY-W710337

Colterol hydrochloride-d9

Colterol hydrochloride-d₉ is the deuterium labeled Colterol hydrochloride (HY-128510A). Colterol hydrochloride is the hydrochloride salt form of Colterol (HY-128510). Colterol hydrochloride is the agonist for adrenergic receptor, and exhibits good affinity to β1-adrenoreceptor (heart) and β2-adrenoreceptor (lung) with IC₅₀ of 645 nM and 147 nM. Colterol hydrochloride exhibits potential as a bronchodilator .

HY-100935S

Cimaterol-d7
Cimaterol-d₇ is the deuterium labeled Cimaterol. Cimaterol is a potent agonist of β-adrenergic receptors (pEC50s=8.13, 8.78, and 6.62 for human β1, β2, and β3, respectively). Cimaterol has been used in farmed animals to increase carcass mass and to alter muscle and fat deposition.

HY-152051S

Mabuterol-d9 hydrochloride

Mabuterol-d₉ (hydrochloride) is deuterium labeled Mabuterol (hydrochloride). Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

HY-W707640

Salbutamol-d4

Salbutamol-d₄ (Albuterol-d₄; AH-3365-d₄) is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is a short-acting beta-2 adrenergic receptor agonist with oral activity. Salbutamol promotes tumorigenesis of gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol is used to study bronchospasms caused by asthma and chronic obstructive pulmonary disease (COPD) .

HY-W751275

Ractopamine-13C2

Ractopamine- ¹³C₂ is the ¹³C-labeled Ractopamine (HY-113781). Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-W751276

Ractopamine-13C6

Ractopamine- ¹³C₆ is the ¹³C-labeled Ractopamine (HY-113781). Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-N0166S

Gramine-d2

Gramine-d₂ is the deuterium labeled Gramine . Gramine (Donaxine) is a natural alkaloid isolated from giant reed , acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-113781S

Ractopamine-d6

Ractopamine-d₆ is the deuterium labeled Ractopamine (HY-113781). Ractopamine (LY031537) hydrochloride is a potent β-adrenergic receptor (βAR) agonist with K_d values of ~25 nM for pig β₁AR and β₂AR. Ractopamine hydrochloride is linked to protein metabolism. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-B1421S1

Ractopamine-d9 hydrochloride

Ractopamine-d₉ (LY031537-d₉) hydrochloride is the deuterium labeled Ractopamine hydrochloride (HY-B1421). Ractopamine (LY031537) hydrochloride is a potent β-adrenergic receptor (βAR) agonist with K_d values of ~25 nM for pig β₁AR and β₂AR. Ractopamine hydrochloride is linked to protein metabolism. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-B1421S3

Ractopamine-d5 hydrochloride

Ractopamine-d₅ (LY031537-d₅) hydrochloride is the deuterium labeled Ractopamine hydrochloride (HY-B1421). Ractopamine (LY031537) hydrochloride is a potent β-adrenergic receptor (βAR) agonist with K_d values of ~25 nM for pig β₁AR and β₂AR. Ractopamine hydrochloride is linked to protein metabolism. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-B1421S2

Ractopamine-d3 hydrochloride

Ractopamine-d₃ (LY031537-d₃) hydrochloride is the deuterium labeled Ractopamine hydrochloride (HY-B1421). Ractopamine hydrochloride (LY031537) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine hydrochloride also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine hydrochloride promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

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adrenergic receptor agonist

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