1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Tianeptine

Tianeptine 

Cat. No.: HY-90003 Purity: 99.24%
Handling Instructions

Tianeptine is a selective facilitator of 5-HT uptake. Tianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50>10 μM) and has no effect on noradrenalin or dopamine uptake. Tianeptine has antidepressant, anxiolytic, analgesic and neuroprotective activities.

For research use only. We do not sell to patients.

Tianeptine Chemical Structure

Tianeptine Chemical Structure

CAS No. : 72797-41-2

Size Stock
10 mM * 1 mL in DMSO Get quote
5 mg USD 79 Get quote
10 mg USD 132 Get quote
50 mg USD 264 Get quote

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Description

Tianeptine is a selective facilitator of 5-HT uptake. Tianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50>10 μM) and has no effect on noradrenalin or dopamine uptake. Tianeptine has antidepressant, anxiolytic, analgesic and neuroprotective activities[1][2][3][4].

IC50 & Target

serotonin

 

Clinical Trial
Molecular Weight

436.95

Formula

C₂₁H₂₅ClN₂O₄S

CAS No.

72797-41-2

SMILES

O=C(CCCCCCNC(C1=CC=CC=C1N2C)C3=CC=C(C=C3S2(=O)=O)Cl)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (22.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2886 mL 11.4430 mL 22.8859 mL
5 mM 0.4577 mL 2.2886 mL 4.5772 mL
10 mM 0.2289 mL 1.1443 mL 2.2886 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.29 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (2.29 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (2.29 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

Tianeptine5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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Tianeptine
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HY-90003
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