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Cat. No.: HY-178319

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Photoazolol-1

Name: Photoazolol-1
Brand: MedChemExpress
SKU: HY-178319
Availability: PreOrder

(Synonyms: PZL-1)

Photoazolol-1 is a β-adrenergic receptor (βAR)-blocker derivative. Photoazolol-1 can transfer from an inverse agonist to a neutral antagonist upon photoactivation.

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CAS No.: 2482779-07-5
화학식: C₂₀H₂₆N₄O₃
분자량:370.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Photoazolol-1 Chemical Structure

CAS No.: 2482779-07-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Photoazolol-1 is a β-adrenergic receptor (βAR)-blocker derivative. Photoazolol-1 can transfer from an inverse agonist to a neutral antagonist upon photoactivation^[1].

IC₅₀ & Target

^[1]

β-adrenoceptor

All Adrenergic Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	1.72 nM Compound: PZL-1	Antagonist activity at ADRB2 endogenously expressed in HEK293 cells transfected with cAMP FRET biosensor assessed as inhibition of cimaterol-induced response pre-incubated for 45 mins under dark conditions by FRET assay Antagonist activity at ADRB2 endogenously expressed in HEK293 cells transfected with cAMP FRET biosensor assessed as inhibition of cimaterol-induced response pre-incubated for 45 mins under dark conditions by FRET assay	[PMID: 32686936]
HEK293	IC₅₀	28.94 nM Compound: PZL-1	Antagonist activity at ADRB2 endogenously expressed in HEK293 cells transfected with cAMP FRET biosensor assessed as inhibition of cimaterol-induced response pre-incubated for 45 mins under constant violet light conditions by FRET assay Antagonist activity at ADRB2 endogenously expressed in HEK293 cells transfected with cAMP FRET biosensor assessed as inhibition of cimaterol-induced response pre-incubated for 45 mins under constant violet light conditions by FRET assay	[PMID: 32686936]

Chemical Information

CAS No. 2482779-07-5
분자량 370.45
화학식 C₂₀H₂₆N₄O₃
SMILES

CC(C)NC[C@H](O)COC1=CC=CC=C1/N=N/C2=CC=C(NC(C)=O)C=C2
Synonyms

PZL-1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Robin Stipp, et al. Time-resolved structures of β2-adrenergic receptor modulation by a photoswitchable beta-blocker. bioRxiv 2025.09.03.673938

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=

Concentration Concentration

×

Volume Volume

×

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

×

Volume _(start) Volume _(start)

=

Concentration _(final) Concentration _(final)

×

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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Photoazolol-1

All Adrenergic Receptor Isoforms

Biological Activity

제품 설명

IC50 & Target

Cellular Effect

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Photoazolol-1 Related Classifications

HY-178319 Related Classifications

Bioz

Keywords

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