1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
    5-HT Receptor
    Adrenergic Receptor
  3. BMY-14802 hydrochloride

BMY-14802 hydrochloride (Synonyms: BMY-14802-1; BMS 181100 hydrochloride)

Cat. No.: HY-108509
Handling Instructions

BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects.

For research use only. We do not sell to patients.

BMY-14802 hydrochloride Chemical Structure

BMY-14802 hydrochloride Chemical Structure

CAS No. : 105565-55-7

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Description

BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects[1][2][3].

IC50 & Target[1]

sigma Receptor

112 nM (IC50)

5-HT1A Receptor

 

α1-adrenergic receptor

 

In Vitro

Similar to other 5-HT1A agonists, BMY-14802 hydrochloride affects the firing of 5-HTergic and catecholaminergic neurons and affects behaviors mediated by 5-HT in a 5-HT1A-sensitive manner. BMY-14802 hydrochloride is devoid of significant affinity for the D2 receptor[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BMY-14802 (5 mg/kg, 10 mg/kg or 20 mg/kg, ip; once) hydrochloride shows anti-dyskinetic efficacy across a 4-fold dose range against L-DOPA-induced dyskinesias (LID) and is also effective in reducing D1 and D2 receptor agonist-induced dyskinesias. Importantly, at anti-LID doses, BMY-14802 hydrochloride does not affect the efficacy of L-DOPA against lesion-induced akinesia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

384.85

Formula

C₁₈H₂₃ClF₂N₄O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
BMY-14802 hydrochloride
Cat. No.:
HY-108509
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