2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor Adrenergic Receptor
  4. Agroclavine

Agroclavine acts as an agonist of the D1-dopamine receptor and α1-adrenergic receptor. Agroclavine enhances the sensitivity of the brain to magnetic fields; it impairs spatial memory without affecting hippocampal long-term potentiation (LTP). Agroclavine exerts bidirectional regulatory effects on immune activity: it enhances NK cell activity with low toxicity under normal conditions, while it inhibits NK cell activity and exhibits significant cardiac and hepatic toxicity under stress conditions. Agroclavine can be used for research on neuroelectrophysiology, learning and memory, and immunoregulation.

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Agroclavine

Agroclavine Chemical Structure

CAS No. : 548-42-5

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Agroclavine Related Antibodies

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Description

Agroclavine acts as an agonist of the D1-dopamine receptor and α1-adrenergic receptor. Agroclavine enhances the sensitivity of the brain to magnetic fields; it impairs spatial memory without affecting hippocampal long-term potentiation (LTP). Agroclavine exerts bidirectional regulatory effects on immune activity: it enhances NK cell activity with low toxicity under normal conditions, while it inhibits NK cell activity and exhibits significant cardiac and hepatic toxicity under stress conditions. Agroclavine can be used for research on neuroelectrophysiology, learning and memory, and immunoregulation[1][2][3].

IC50 & Target[1][2][3]

D1 Receptor

 

α1-adrenergic receptor

 

In Vitro

Agroclavine exhibits cytostatic activity against L5178y mouse lymphoma cells, with an EC50 value of 6.3 μM[3].
Agroclavine (0.01-0.1 μM) enhances NK cell activity and promotes the production of interleukin-2 and interferon-γ[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Agroclavine Related Antibodies
In Vivo

Agroclavine (50 μg/kg; i.p.) induces spatial memory impairment in male Wistar rats without altering hippocampal CA1 long-term potentiation[1].
Agroclavine (50 μg/kg; i.p.; single dose) alters cortical and hippocampal EEG activity in healthy rats, and potentiates a robust, persistent increase in hippocampal beta2 activity (46.3% above pre-exposure levels) following combined magnetic field exposure[2].
Agroclavine (0.05-0.5 mg/kg; i.p.; single dose) at 0.5 mg/kg significantly increases splenic NK cell activity and serum CKMB levels in non-stressed normal male Wistar-Kyoto rats, while the 0.05 mg/kg dose has minimal, non-significant effects on these endpoints[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (male, 300-360 g)[2]
Dosage: 50 μg/kg
Administration: i.p.; single dose
Result: Significantly increased delta (0.5-3.5 Hz) EEG activity in both the cortex and hippocampus during the first 30 minutes post-injection, with a larger effect in the cortex.
Decreased alpha (7.6-12.5 Hz) EEG activity in both the cortex and hippocampus, and decreased beta1 (12.6-17.5 Hz) activity in both regions, with a significantly greater attenuation in the cortex than the hippocampus.
Produced a significant increase in hippocampal beta2 activity, with only a non-significant trend toward increased beta2 activity in the cortex.
Potentiated an immediate, robust increase in hippocampal beta2 (22.5-30.5 Hz) activity relative to pre-exposure levels when combined with CMF exposure starting 1 hour post-injection; this effect persisted throughout the 30-minute post-exposure period, with a 46.3% increase in beta2 activity relative to pre-exposure values.
Did not produce significant changes in cortical EEG in agroclavine-pretreated rats during CMF exposure.
Animal Model: Wistar-Kyoto (3-month-old male, 230-280 g)[3]
Dosage: 0.05 mg/kg; 0.5 mg/kg
Administration: i.p.; single dose
Result: Caused a moderate, non-significant increase in spleen NK cell activity at 0.05 mg/kg.
Caused a significant increase in spleen NK cell activity at 0.5 mg/kg.
Showed no significant effect on serum CKMB at 0.05 mg/kg.
Caused a significant increase in serum CKMB at 0.5 mg/kg.
Had no effect on serum ALT at both 0.05 mg/kg and 0.5 mg/kg.
Animal Model: Wistar-Kyoto (3-month-old male, 230-280 g; restraint and immersion in 23°C water stress model)[3]
Dosage: 0.05 mg/kg; 0.5 mg/kg
Administration: i.p.; single dose; 30 min pre-stress
Result: Caused a significant decrease in spleen NK cell activity at 0.05 mg/kg compared to stressed control rats.
Caused a significant decrease in spleen NK cell activity at 0.5 mg/kg compared to stressed control rats.
Showed no significant effect on serum CKMB and ALT levels at 0.05 mg/kg relative to stressed controls.
Caused a more than twofold significant increase in serum CKMB at 0.5 mg/kg compared to stressed control rats.
Caused a significant increase in serum ALT at 0.5 mg/kg compared to stressed control rats.
Molecular Weight

238.33

Formula

C16H18N2
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

CN1[C@@]2([H])[C@@](C=C(C1)C)([H])C3=CC=CC4=C3C(C2)=CN4
Structure Classification
Initial Source

Saccharomyces cerevisiae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Agroclavine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Agroclavine548-42-5Dopamine ReceptorAdrenergic ReceptorBeta Receptordopamine receptorL5178y mouse lymphoma cellsinterleukin-1αinterferon-gammaWistar-Kyoto ratsα1-adrenoceptorhippocampal CA1 regioninterleukin-2natural killer cellmale Wistar ratsInhibitorinhibitorinhibit

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