548-42-5
Chemical Structure
Agroclavine
- CAS No.: 548-42-5
- Formula:C16H18N2
- Molecular Weight:238.33
IUPAC Name: (6aR,10aR)-7,9-dimethyl-4,6,6a,7,8,10a-hexahydroindolo[4,3-fg]quinoline
InChIKey: XJOOMMHNYOJWCZ-UKRRQHHQSA-N
SMILES: CN1[C@@]2([H])[C@@](C=C(C1)C)([H])C3=CC=CC4=C3C(C2)=CN4
Biological Activity: Agroclavine acts as an agonist of the D1-dopamine receptor and α1-adrenergic receptor. Agroclavine enhances the sensitivity of the brain to magnetic fields; it impairs spatial memory without affecting hippocampal long-term potentiation (LTP). Agroclavine exerts bidirectional regulatory effects on immune activity: it enhances NK cell activity with low toxicity under normal conditions, while it inhibits NK cell activity and exhibits significant cardiac and hepatic toxicity under stress conditions. Agroclavine can be used for research on neuroelectrophysiology, learning and memory, and immunoregulation[1][2][3].
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Agroclavine | Agroclavine acts as an agonist of the D1-dopamine receptor and α1-adrenergic receptor. Agroclavine enhances the sensitivity of the brain to magnetic fields; it impairs spatial memory without affecting hippocampal long-term potentiation (LTP). Agroclavine exerts bidirectional regulatory effects on immune activity: it enhances NK cell activity with low toxicity under normal conditions, while it inhibits NK cell activity and exhibits significant cardiac and hepatic toxicity under stress conditions. Agroclavine can be used for research on neuroelectrophysiology, learning and memory, and immunoregulation. | |||||||||||||||||||||
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- [1]. Vorobyov V, et al. Spatial memory deficits initiated by agroclavine injection or olfactory bulbectomy in rats are characterized by different levels of long-term potentiation expression in the hippocampus. Int J Neurosci. 2020;130(12):1225-1229. [Content Brief]
- [2]. Vorobyov V, et al. Agroclavine potentiates hippocampal EEG effects of weak combined magnetic field in rats. Brain Res Bull. 2009;80(1-2):1-8. [Content Brief]
- [3]. Starec M, et al. Effect of agroclavine on NK activity in vivo under normal and stress conditions in rats. Physiol Res. 2001;50(5):513-519. [Content Brief]
Keywords
