1. GPCR/G Protein
  2. Adrenergic Receptor

Solabegron (Synonyms: GW 427353)

Cat. No.: HY-19436
Handling Instructions

Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM. Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome.

For research use only. We do not sell to patients.

Solabegron Chemical Structure

Solabegron Chemical Structure

CAS No. : 252920-94-8

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM[1]. Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome[1].

IC50 & Target

EC50: 22 nM (β3-AR in cells)[1].

In Vivo

Solabegron (GW427353) at 3 mg/kg i.v. evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs. The low dose (1 mg/kg) shows no significant activity[1].

Animal Model: Adult female beagle dogs (6-10 kg)[1].
Dosage: 1, 3 mg/kg.
Administration: I.V. once.
Result: Dosage of 3 mg/kg evoked an increase in micturition volume threshold.
References
Molecular Weight

410.89

Formula

C₂₃H₂₃ClN₂O₃

CAS No.

252920-94-8

SMILES

O=C(C1=CC(C2=CC=CC(NCCNC[[email protected]@H](C3=CC=CC(Cl)=C3)O)=C2)=CC=C1)O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Solabegron
Cat. No.:
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Solabegron

Cat. No.: HY-19436