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Cat. No.: HY-19436A

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Solabegron hydrochloride

(Synonyms: GW 427353B)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Solabegron hydrochloride is a selective β₃-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β₃-AR, with an EC₅₀ value of 22 nM. Solabegron hydrochloride (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome.

For research use only. We do not sell to patients.

CAS No.: 451470-34-1
Formula: C₂₃H₂₄Cl₂N₂O₃
Molecular Weight:447.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Solabegron hydrochloride Chemical Structure

CAS No.: 451470-34-1

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Biological Activity

Description

Solabegron hydrochloride is a selective β₃-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β₃-AR, with an EC₅₀ value of 22 nM^[1]. Solabegron hydrochloride (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome^[1].

All Adrenergic Receptor Isoforms :

Chemical Information

CAS No. 451470-34-1
Molecular Weight 447.35
Formula C₂₃H₂₄Cl₂N₂O₃
SMILES

O=C(C1=CC(C2=CC=CC(NCCNC[C@@H](C3=CC=CC(Cl)=C3)O)=C2)=CC=C1)O.[H]Cl
Synonyms

GW 427353B
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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PLoS One

Vibegron shows high selectivity and potent agonist activity for β3-adrenoceptors, irrespective of receptor density. [Abstract]

2023 Sep 1;18(9):e0290685. PMID: 37656760

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hicks A, et al. GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. J Pharmacol Exp Ther. 2007 Oct;323(1):202-9. [Content Brief]

[2]. Andersson KE, et al. Selective β3-adrenoceptor agonists for the treatment of overactive bladder. J Urol. 2013 Oct;190(4):1173-80. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Solabegron hydrochloride

1 Cited Publications

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Solabegron hydrochloride

Publications Citing Use of MedChemExpress (MCE) Solabegron hydrochloride

All Adrenergic Receptor Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Solabegron hydrochloride Related Classifications

HY-19436A Related Classifications