451470-34-1
Chemical Structure
Solabegron hydrochloride
Synonym(s): GW 427353B
- CAS No.: 451470-34-1
- Formula:C23H24Cl2N2O3
- Molecular Weight:447.35
IUPAC Name: (R)-3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-[1,1'-biphenyl]-3-carboxylic acid hydrochloride
InChIKey: PMXCGBVBIRYFPR-FTBISJDPSA-N
SMILES: O=C(C1=CC(C2=CC=CC(NCCNC[C@@H](C3=CC=CC(Cl)=C3)O)=C2)=CC=C1)O.[H]Cl
Biological Activity: Solabegron hydrochloride is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM[1]. Solabegron hydrochloride (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome[1].
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Solabegron hydrochloride | Solabegron hydrochloride is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM. Solabegron hydrochloride (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome. | |||||||||||||||||||||
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