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Cat. No.: HY-124208

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L-770644

L-770644 is an orally active, potent and selective agonist of the human β3 adrenergic receptor (EC₅₀ = 13 nM).

For research use only. We do not sell to patients.

CAS No.: 173901-95-6
Formula: C₃₀H₃₇N₇O₄S
Molecular Weight:591.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

L-770644 Chemical Structure

CAS No.: 173901-95-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

L-770644 is an orally active, potent and selective agonist of the human β3 adrenergic receptor (EC₅₀ = 13 nM)^[1].

IC₅₀ & Target

Beta-3 adrenergic receptor

13 nM (EC₅₀)

All Adrenergic Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	1600 nM Compound: 9c	Inhibitory activity against cloned human Beta-2 adrenergic receptor in the presence of [125I]iodocyanopindolol in CHO cells by receptor binding assay Inhibitory activity against cloned human Beta-2 adrenergic receptor in the presence of [125I]iodocyanopindolol in CHO cells by receptor binding assay	[PMID: 10340609]
CHO	IC₅₀	3400 nM Compound: 9c	Inhibitory activity against cloned human Beta-1 adrenergic receptor in the presence of [125I]iodocyanopindolol expressed in CHO cells by receptor binding assay Inhibitory activity against cloned human Beta-1 adrenergic receptor in the presence of [125I]iodocyanopindolol expressed in CHO cells by receptor binding assay	[PMID: 10340609]
CHO	IC₅₀	92 nM Compound: 9c	Inhibitory activity against cloned human Beta-3 adrenergic receptor in the presence of [125I]iodocyanopindolol expressed in CHO cells by receptor binding assay Inhibitory activity against cloned human Beta-3 adrenergic receptor in the presence of [125I]iodocyanopindolol expressed in CHO cells by receptor binding assay	[PMID: 10340609]

Chemical Information

CAS No. 173901-95-6
Molecular Weight 591.72
Formula C₃₀H₃₇N₇O₄S
SMILES

O=C1N(C2=CC=C(C=C2)S(NC3=CC=C(C=C3)CCNC[C@@H](C4=CN=CC=C4)O)(=O)=O)N=NN1CCCC5CCCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shih TL, et al. L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability. Bioorg Med Chem Lett. 1999 May 3;9(9):1251-4. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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L-770644

All Adrenergic Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

L-770644 Related Classifications

HY-124208 Related Classifications