Methoxamine
Methoxamine is a selective alpha1-adrenergic receptor agonist. Methoxamine causes vasoconstriction and increased peripheral vascular resistance. Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery.
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- CAS No.: 390-28-3
- Formula: C11H17NO3
- Molecular Weight:211.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar-Kyoto rats weighing 320-47 g ( based on the exponentially tapered T-tube model)[2]
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Dosage:0.025 mg/kg
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Administration:Femoral vein
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Result:Had a greater effect on the peripheral resistance vessels than on the Winkessel vessels in the rat systemic circulation.
Chemical Information
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CAS No. 390-28-3
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Molecular Weight 211.26
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Formula C11H17NO3
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SMILES
COC1=CC=C(C(C(C(N)C)O)=C1)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sanders AB. The roles of methoxamine and norepinephrine in electromechanical dissociation. Ann Emerg Med. 1984;13(9 Pt 2):835-839. [Content Brief]
[2]. Chang KC. Hypertensive effects of methoxamine on arterial mechanics in rats: analysis based on exponentially tapered T-tube model. Eur J Pharmacol. 1998;350(2-3):195-202. [Content Brief]
[3]. Takeuchi K, et al. Methoxamine-induced release of endogenous ATP from rabbit pulmonary artery. Eur J Pharmacol. 1994;254(3):287-290. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Methoxamine Related Classifications
HY-B1298A Related Classifications
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