390-28-3
390-28-3
Chemical Structure
Methoxamine
- CAS No.: 390-28-3
- Formula:C11H17NO3
- Molecular Weight:211.26
IUPAC Name: 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
InChIKey: WJAJPNHVVFWKKL-UHFFFAOYSA-N
SMILES: COC1=CC=C(C(C(C(N)C)O)=C1)OC
Biological Activity: Methoxamine is a selective alpha1-adrenergic receptor agonist. Methoxamine causes vasoconstriction and increased peripheral vascular resistance[1][2]. Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery[3].
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Methoxamine | Methoxamine is a selective alpha1-adrenergic receptor agonist. Methoxamine causes vasoconstriction and increased peripheral vascular resistance. Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery. | |||||||||||||||||||||
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References
- [1]. Sanders AB. The roles of methoxamine and norepinephrine in electromechanical dissociation. Ann Emerg Med. 1984;13(9 Pt 2):835-839. [Content Brief]
- [2]. Chang KC. Hypertensive effects of methoxamine on arterial mechanics in rats: analysis based on exponentially tapered T-tube model. Eur J Pharmacol. 1998;350(2-3):195-202. [Content Brief]
- [3]. Takeuchi K, et al. Methoxamine-induced release of endogenous ATP from rabbit pulmonary artery. Eur J Pharmacol. 1994;254(3):287-290. [Content Brief]
