1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. LY377604

LY377604 

Cat. No.: HY-13713
Handling Instructions

LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist.

For research use only. We do not sell to patients.

LY377604 Chemical Structure

LY377604 Chemical Structure

CAS No. : 204592-94-9

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Description

LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist.

IC50 & Target

EC50: 2.4 nM (human β3-adrenergic receptor)[1]
β1-adrenergic receptor, β2-adrenergic receptor[1]

In Vitro

LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist. LY377604 causes a maximal increase in cyclic adenosine monophosphate (cAMP) levels, but does not stimulate cAMP accumulation in CHO cells transfected with either the human β1 adrenergic receptor or the human β2 adrenergic receptor[1].

In Vivo

Administration of LY377604 to male Long-Evans rats fed a caloric dense diet results in stimulation of lipid utilization. This is observed as a decrease in respiratory quotient and persists for about 4 h before returning to that measured from vehicle-treated rats[1].

Molecular Weight

524.61

Formula

C₃₁H₃₂N₄O₄

CAS No.

204592-94-9

SMILES

O=C(C1=CC=C(OC2=CC=C(CC(C)(NC[[email protected]](O)COC3=CC=CC(N4)=C3C5=C4C=CC=C5)C)C=C2)N=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LY377604LY 377604LY-377604Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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