LY-377604 hydrochloride
LY377604 hydrochloride is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist.
For research use only. We do not sell to patients.
- CAS No.: 204592-97-2
- Formula: C31H33ClN4O4
- Molecular Weight:561.07
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Adrenergic Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
>3160 nM
Compound: LY-377604.HCl
|
Agonist activity at human adrenergic beta1 receptor expressed in DHB-11 CHO cells assessed as cAMP accumulation after 20 mins by scintillation proximity assay
Agonist activity at human adrenergic beta1 receptor expressed in DHB-11 CHO cells assessed as cAMP accumulation after 20 mins by scintillation proximity assay
|
[PMID: 24900353] |
| CHO | EC50 |
>3160 nM
Compound: LY-377604.HCl
|
Agonist activity at human adrenergic beta2 receptor expressed in DHB-11 CHO cells assessed as cAMP accumulation after 20 mins by scintillation proximity assay
Agonist activity at human adrenergic beta2 receptor expressed in DHB-11 CHO cells assessed as cAMP accumulation after 20 mins by scintillation proximity assay
|
[PMID: 24900353] |
| CHO | EC50 |
2.4 nM
Compound: LY-377604.HCl
|
Agonist activity at human adrenergic beta3 receptor expressed in DHB-11 CHO cells assessed as cAMP accumulation after 20 mins by scintillation proximity assay
Agonist activity at human adrenergic beta3 receptor expressed in DHB-11 CHO cells assessed as cAMP accumulation after 20 mins by scintillation proximity assay
|
[PMID: 24900353] |
| CHO | EC50 |
5 nM
Compound: LY-377604.HCl
|
Agonist activity at rat adrenergic beta3 receptor expressed in DHB-11 CHO cells assessed as cAMP accumulation after 20 mins by scintillation proximity assay
Agonist activity at rat adrenergic beta3 receptor expressed in DHB-11 CHO cells assessed as cAMP accumulation after 20 mins by scintillation proximity assay
|
[PMID: 24900353] |
Chemical Information
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CAS No. 204592-97-2
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Molecular Weight 561.07
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Formula C31H33ClN4O4
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SMILES
O=C(C1=CC=C(OC2=CC=C(CC(C)(NC[C@H](O)COC3=CC=CC(N4)=C3C5=C4C=CC=C5)C)C=C2)N=C1)N.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)