1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Tolazoline hydrochloride

Tolazoline hydrochloride (Synonyms: Imidaline hydrochloride; NSC35110 hydrochloride)

Cat. No.: HY-A0066A Purity: ≥98.0%
Handling Instructions

Tolazoline (hydrochloride)(Imidaline (hydrochloride)) Hcl is a non-selective competitive α-adrenergic receptor antagonist.

For research use only. We do not sell to patients.

Tolazoline hydrochloride Chemical Structure

Tolazoline hydrochloride Chemical Structure

CAS No. : 59-97-2

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 72 In-stock
Estimated Time of Arrival: December 31
5 g USD 144 In-stock
Estimated Time of Arrival: December 31
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Other Forms of Tolazoline hydrochloride:

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Description

Tolazoline (hydrochloride)(Imidaline (hydrochloride)) Hcl is a non-selective competitive α-adrenergic receptor antagonist. IC50 value: Target: α-adrenoceptor antagonist Tolazoline can be synthesized by the heterocyclation of the ethyl ester of iminophenzylacetic acid with ethylene diamine, which forms the desired product. The structure of tolazoline is strikingly similar to α-adrenergic agonists, which are antiedema sympathomimetics.

Molecular Weight

196.68

Formula

C10H13ClN2

CAS No.
SMILES

[H]Cl.C1(CC2=CC=CC=C2)=NCCN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (254.22 mM)

DMSO : 33.33 mg/mL (169.46 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0844 mL 25.4220 mL 50.8440 mL
5 mM 1.0169 mL 5.0844 mL 10.1688 mL
10 mM 0.5084 mL 2.5422 mL 5.0844 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (508.44 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.71 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.71 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.71 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Tolazoline hydrochloride
Cat. No.:
HY-A0066A
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