1. GPCR/G Protein
  2. Adrenergic Receptor
  3. β3-AR agonist 1

β3-AR agonist 1 

Cat. No.: HY-101514
Handling Instructions

β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold).

For research use only. We do not sell to patients.

β3-AR agonist 1 Chemical Structure

β3-AR agonist 1 Chemical Structure

CAS No. : 1283125-73-4

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Description

β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold)[1].

IC50 & Target

EC50: 18 nM (β3-AR)[1]

In Vivo

β3-AR agonist 1 (compound 15) shows dose-dependent β3-AR-mediated responses in marmoset urinary bladder smooth muscle, has a desirable metabolic stability and pharmacokinetic profile (Cmax and AUC), and do not obviously affect heart rate or mean blood pressure when administered intravenously (3 mg/kg) to anesthetized rats[1].

Molecular Weight

444.55

Formula

C₂₂H₂₈N₄O₄S

CAS No.

1283125-73-4

SMILES

O=S(NC1=CC([[email protected]@H](O)CNCCOC2=CC(NN=C3C)=C3C=C2)=CC=C1)(C4CCC4)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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β3-AR agonist 1
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HY-101514
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