1283125-73-4
1283125-73-4
Chemical Structure
β3-AR agonist 1
- CAS No.: 1283125-73-4
- Formula:C22H28N4O4S
- Molecular Weight:444.55
IUPAC Name: (R)-N-(3-(1-hydroxy-2-((2-((3-methyl-1H-indazol-6-yl)oxy)ethyl)amino)ethyl)phenyl)cyclobutanesulfonamide
InChIKey: QCXSPIQLVJHNHV-QFIPXVFZSA-N
SMILES: O=S(NC1=CC([C@@H](O)CNCCOC2=CC(NN=C3C)=C3C=C2)=CC=C1)(C4CCC4)=O
Biological Activity: β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold)[1].
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β3-AR agonist 1 | β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold). | |||||||||||||||||||||
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References
Keywords
