1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. AGN 192836

AGN 192836 

Cat. No.: HY-100300
Handling Instructions

AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.

For research use only. We do not sell to patients.

AGN 192836 Chemical Structure

AGN 192836 Chemical Structure

CAS No. : 171102-29-7

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Description

AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.

IC50 & Target

EC50: 8.7 nM (α2A), 41 nM (α2B), 6.6 nM (α2C)[1]

Ki: 1.7 nM (α2A), 82 nM (α2B), 19 nM (α2C)[1]

In Vitro

Binding assays demonstrates that AGN 192836 is 1200-fold selective for the α2A-receptor relative to the α1-receptor, 50-fold selective for the α2A-receptor relative to the α2B-receptor, and 10-fold selective for the α2Areceptor relative to the α2C-receptor[1].

In Vivo

AGN 192836 is equally efficacious when compared to brimonidine for the reduction of intraocular pressure upon topical administration to the rabbit and more efficacious than brimonidine for the reduction of blood pressure upon intravenous administration to monkey[1].

Molecular Weight

231.25

Formula

C₁₂H₁₃N₃O₂

CAS No.

171102-29-7

SMILES

CC1=C2OCCOC2=CC=C1NC3=NC=CN3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[1]

Rabbit: A single drop of either brimonidine or AGN 192836 (0.001%) is applied unilaterally to rabbit eyes, and the intraocular pressure is monitored for 6 h post-administration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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AGN 192836
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