1. Isoetharine

Isoetharine (Isoetarine) is an orally active selective agonist of β-adrenergic receptors. Isoetharine is a catechol-like agent and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator.

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Isoetharine Chemical Structure

Isoetharine Chemical Structure

CAS No. : 530-08-5

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Description

Isoetharine (Isoetarine) is an orally active selective agonist of β-adrenergic receptors. Isoetharine is a catechol-like agent and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator[1][2].

In Vitro

Isoetharine (50 μM, 18 hours) can induce the production and release of [35S]sulfated metabolites of catecholic drugs in HepG2 human hepatoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Isoetharine inhibits melanin deposition with the AC50 value of 5.10 mM and complete inhibition of pigment production at 7.50 mM in the zebrafish larvae model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

239.31

Formula

C13H21NO3

CAS No.
SMILES

OC1=CC=C(C(O)C(NC(C)C)CC)C=C1O

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Isoetharine
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HY-B1481A
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