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Results for "

Cap 1 synthons

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Proteasome Cap Targeting Chimeras (3) ADC Linker (2) Amino Acid Derivatives (1) Androgen Receptor (1) Antibiotic (6) Antifolate (1) Apoptosis (2) Arp2/3 Complex (1) Autophagy (2) Bacterial (15) Beta-lactamase (6) Biochemical Assay Reagents (24) c-Myc (1) CCR (1) CD19 (1) CHIKV (1) CMV (2) Cytochrome P450 (1) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (3) DNA/RNA Synthesis (58) Drug Derivative (3) Drug Intermediate (8) Drug Isomer (1) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (22) Endonuclease (2) Epigenetic Reader Domain (1) Eukaryotic Initiation Factor (eIF) (8) FKBP (2) Fluorescent Dye (2) Fungal (3) G-quadruplex (1) Glutathione Peroxidase (1) HBV (1) HDAC (1) Histone Methyltransferase (1) HIV (1) HSV (1) Influenza Virus (44) Isotope-Labeled Compounds (20) Liposome (3) MAPKAPK2 (MK2) (1) Mitochondrial Metabolism (1) MMP (1) mRNA (4) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (37) Orthopoxvirus (1) Parasite (4) Phosphoramidites (3) Polo-like Kinase (PLK) (1) Potassium Channel (3) PROTACs (2) Proteasome (6) Reactive Oxygen Species (ROS) (3) Reference Standards (7) SARS-CoV (6) Small Interfering RNA (siRNA) (9) Somatostatin Receptor (2) Target Protein Ligand-Linker Conjugates (1) Thymidylate Synthase (1) Topoisomerase (1) TRP Channel (1) Tyrosinase (1) Virus Protease (1)
By Research Areas:	Cancer (37) Cardiovascular Disease (3) Infection (77) Inflammation/Immunology (20) Metabolic Disease (22) Neurological Disease (3)
Click Chemistry:	Azide (1)
Oligonucleotides:	Adenosine (1) Nucleotide Analogs (11) Adenine (1) Rat Pre-designed siRNA Sets (3) Phospholipids (5) mRNA (3) Other Phosphoramidite (2) Cap Analogs (34) Adenine Nucleotide (2) Gene Editing (2) Cholesterol (2) siRNAs (9) Fluorescent Lipids (1) Guanine Nucleotide (2) Nucleoside Analogs (8) Mouse Pre-designed siRNA Sets (2) Reporter Genes (1) Human Pre-designed siRNA Sets (4) Phosphoramidites (3)

247

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Proteasome Cap Targeting Chimeras

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0148A

Halofantrine hydrochloride 2 Publications Verification SKF-102886; WR-171669 hydrochloride	Parasite Fungal Reactive Oxygen Species (ROS) Potassium Channel	Infection
Halofantrine hydrochloride (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent with oral activity. Halofantrine hydrochloride inhibits the *Cap1*-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria ^[1] .

HY-148771

MTX-23 1 Publications Verification PROTAC AR-V7 degrader-2	PROTACs Androgen Receptor Apoptosis	Cancer
MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis ^[1].

HY-145974A

m7GpppAmpG ammonium solution (100 mM) m7G(5')ppp(5')(2'OMeA)pG ammonium	DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF)	Others
m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a K_D value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research ^[1] .

HY-174497

eGFP mRNA	mRNA	Others
eGFP mRNA expresses green fluorescent protein derived from the jellyfish Aequorea victoria. eGFP is a commonly used direct-detection reporter gene in mammalian cell culture, which produces bright green fluorescence. This product is synthesized without modified nucleosides, with a Cap1 version cap analog at the 5' end and a 100nt PolyA tail at the 3' end. It can be used as a positive reference for IVT (in vitro transcription) or LNP delivery systems.

HY-D0869

CAPS N-Cyclohexyl-3-aminopropanesulfonic acid	Biochemical Assay Reagents	Others Cancer
CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis ^[1] .

HY-P991224

CAP-100	CCR	Inflammation/Immunology Cancer
CAP-100 is a monoclonal antibody that targets CCR7. CAP-100 neutralizes the ligand-binding site and signaling of CCR7. CAP-100 strongly inhibits CCR7-induced migration, extravasation, homing, and survival in chronic lymphocytic leukemia (CLL) samples. CAP-100 triggers potent tumor cell killing, mediated by host immune mechanism. CAP-100 shows a favorable toxicity profile on relevant hematopoietic subsets. CAP-100 is involved in research on anti-tumor and disease such as CLL ^[1].

HY-107823

Cholesteryl acetate Cholesterol 3-acetate; Cholesterin acetate; Cholesterol 3β-acetate	Endogenous Metabolite	Others
Cholesteryl acetate (Cholesterol 3-acetate) is a cholesterol ester that is exported from Saccharomyces cerevisiae via a Pry1-dependent mechanism. Cholesteryl acetate binds to the CAP superfamily protein *Pry1* via interactions dependent on *Pry1*’s caveolin-binding motif ^[1] .

HY-153108

3'-O-Me-m7G(5')ppp(5')A solution (100 mM) ARCA Cap solution (100 mM)	DNA/RNA Synthesis	Others
3'-O-Me-m7G(5')ppp(5')A (ARCA cap) solution (100 mM), anti-reverse cap analog, has a special RNA cap structure. 3'-O-Me-m7G(5')ppp(5')A solution (100 mM) improves mRNA translation efficiency and stability, reduces translational inhibition by proteins such as IFIT1, and enables stronger and longer-lasting expression of the target protein. The RNA cap structure is a common feature of mRNAs in some RNA viruses and eukaryotes, and it serves as a signal for translation initiation ^[1] .

HY-141472

7-Methylguanosine 5'-diphosphate sodium 7-Methyl-GDP sodium; m7GDP sodium	Endogenous Metabolite	Others
7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues ^[1].

HY-W012944

2-Methylcyclopentane-1,3-dione	Biochemical Assay Reagents	Others
2-Methylcyclopentane-1,3-dione is a synthon . 2-Methylcyclopentane-1,3-dione can be used for the synthesis of (±)-α-cuparenone ^[1].

HY-160957

Cap A (Acetonitrile/Acetic Anhydride, 80/20 v/v)	DNA/RNA Synthesis	Others
Cap A (Acetonitrile/Acetic Anhydride, 80/20 v/v) is a capping reagent that can be used in DNA/RNA synthesis ^[1].

HY-105172

TT-232 Cap-232; TLN-232	Somatostatin Receptor	Inflammation/Immunology Cancer
TT-232 (CAP-232), a somatostatin derivative, is a peptide *SSTR1/SSTR4* agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent ^[1] .

HY-145969A

β-S-ARCA triammonium 3’-O-Me-m7G(5')ppp(5')G triammonium	DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF)	Cancer
β-S-ARCA (3'-O-Me-m7G(5')ppp(5')G) triammonium is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. β-S-ARCA triammonium binds eIF4E via electrostatic interactions between its β-sulfur atom and positively charged Arg and Lys residues in the protein binding site. β-S-ARCA triammonium prevents the decapping by Dcp2, increases the mRNA half-life, enhances cap-dependent translation, and increases protein expression in cells. β-S-ARCA triammonium has been applied in researching experimental mRNA-based anticancer vaccines ^[1] .

HY-145973A

3'OMe-m7GpppAmpG ammonium solution (100 mM) m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium solution (100 mM)	DNA/RNA Synthesis	Others
3'OMe-m7GpppAmpG (m7(3'OMeG)(5')ppp(5')(2'OMeA)pG) ammonium solution (100 mM) is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG ammonium shows a significant translational efficiency. 3'OMe-m7GpppAmpG ammonium can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization ^[1].

HY-W352344

2'-Deoxy-L-adenosine	HBV	Infection
2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV) ^[1].

HY-E70081

*mRNA Cap* 2'-O-methyltransferase**	Biochemical Assay Reagents	Others
mRNA Cap 2'-O-methyltransferase uses S-adenosylmethionine (SAM) as a methyl donor to add a methyl group at the 2'-O position of the first nucleotide at the 5’ end of Cap-0 mRNA, resulting in Cap-1 structure. Cap-1 structure promotes translation efficiency, increasing subsequent protein expression ^[1].

HY-160958

Cap B Acetonitrile/N-methylimidazole /pyridine, 50/20/30 v/v/v	Biochemical Assay Reagents	Others
Cap B (Acetonitrile/N-methylimidazole /pyridine, 50/20/30 v/v/v) is a biochemical reagent, which contains 50% Acetonitrile, 20 N-methylimidazole and 30% pyridine. Cap B (Acetonitrile/N-methylimidazole /pyridine, 50/20/30 v/v/v) is utilized as capping agent in oligonucleotide synthesis ^[1].

HY-A0148

Halofantrine SKF-102886 free base; WR-171669	Parasite Fungal Potassium Channel Reactive Oxygen Species (ROS)	Infection Cancer
Halofantrine (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent with oral activity. Halofantrine inhibits the *Cap1*-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria ^[1] .

HY-145977A

m7GpppGmpG ammonium solution (100 mM) m7G(5')ppp(5')(2'OMeG)pG ammonium	DNA/RNA Synthesis	Others
m7GpppGmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86% ^[1].

HY-145974

m7GpppAmpG m7G(5')ppp(5')(2'OMeA)pG	DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF)	Others
m7GpppAmpG (m7G(5')ppp(5')(2'OMeA)pG) is a trinucleotide 5′ end cap analog. m7GpppAmpG binds to eIF4E with a K_D value of 45.6 nM. m7GpppAmpG caps RNA with a capping efficiency of 90%. m7GpppAmpG enhances mRNA stability and translation efficiency. m7GpppAmpG is used in mRNA therapeutic research ^[1] .

HY-143744

Suraxavir marboxil GP681; Cap-dependent endonuclease-IN-3	Endonuclease Influenza Virus	Infection
Suraxavir marboxil (GP681; Cap-dependent endonuclease-IN-3) is a PA subunit cap-dependent endonuclease inhibitor with antiviral activity. Suraxavir marboxil inhibits PA subunit cap-dependent endonuclease activity and inhibits influenza A and/or influenza B viral replication. Suraxavir marboxil can be used alone or in combination with other anti-influenzal agents for the prevention of influenza A and/or influenza B viral infectious diseases. Suraxavir marboxil can be used for the research of influenza A and/or influenza B viral infectious diseases ^[1].

HY-157504

2′-O-Methyl-5′-O-phosphonoadenylyl-(3′→5′)-guanosine TEA	Nucleoside Antimetabolite/Analog	Others
2’-O-Methyl-5’-O-phosphonoadenylyl-(3’→5’)-guanosine (TEA) is a trinucleotide cap analogue that regulates protein expression in living cells ^[1].

HY-RS01880

CAP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for CAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CAP1 Human Pre-designed siRNA Set A CAP1 Human Pre-designed siRNA Set A

HY-145980

m7GpppUpG	Nucleoside Antimetabolite/Analog	Others
m7GpppUpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppUpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures ^[1].

HY-145982

m7GpppCmpG	Nucleoside Antimetabolite/Analog	Others
m7GpppCmpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppCmpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures ^[1].

HY-145979

m7GpppUmpG	Nucleoside Antimetabolite/Analog	Others
m7GpppUmpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppUmpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures ^[1].

HY-145981

m7GpppCpG	Nucleoside Antimetabolite/Analog	Others
m7GpppCpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppCpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures ^[1].

HY-P3911

CAP 37 (20-44)	Bacterial	Infection
CAP 37 (20-44) is a peptide based on amino acid residues 20 through 44 of CAP37. CAP37, a Cationic antimicrobial protein of 37 kDa, is a multifunctional protein ^[1].

HY-145977

m7GpppGmpG	DNA/RNA Synthesis	Others
m7GpppGmpG is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86% ^[1].

HY-109659

1-(3-Aminopropyl)-4-methylpiperazine	Biochemical Assay Reagents DNA Alkylator/Crosslinker	Others
1-(3-Aminopropyl)-4-methylpiperazine is a capping agent. The 1-(3-Aminopropyl)-4-methylpiperazine-capped Poly (β-amino ester) (PBAE) poly (1,4-butanediol diacrylate-co-4-amino-1-butanol) undergoes electrostatic interactions with anionic molecules such as DNA and exhibits low cytotoxicity. The 1-(3-Aminopropyl)-4-methylpiperazine-capped Poly (1,4-butanediol diacrylate-co-4-amino-1-butanol) PBAE effectively delivers nucleic acids in various systems ^[1].

HY-178145

*Mc-Lys(PEG12)-Cap-Ala-Ala-PABC-exatecan*	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Mc-Lys(PEG12)-Cap-Ala-Ala-PABC-exatecan (compound 12) is a Drug-Linker Conjugate for ADC. Mc-Lys(PEG12)-Cap-Ala-Ala-PABC-exatecan contains the ADC linker (Mc-Lys(PEG12)-Cap-Ala-Ala-PABC) (HY-178146) and a DNA topoisomerase I inhibitor Exatecan (HY-13631). Mc-Lys(PEG12)-Cap-Ala-Ala-PABC-exatecan can be used for the development of ADC targeting HER2-positive breast cancer ^[1].

HY-145976

m7GpppGpG	Nucleoside Antimetabolite/Analog	Others
m7GpppGpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppGpG prevents premature degradation by 5′-exonucleases and recruits proteins required for pre-mRNA splicing, mRNA transport and initiation of protein biosynthesis ^[1].

HY-79096

Boc-L-phenylalanine	Biochemical Assay Reagents Drug Intermediate	Others
Boc-L-phenylalanine is a Boc-protected L-phenylalanine that can be used in the synthesis of other active compounds. Boc-L-phenylalanine is also a capping agent ^[1] .

HY-116229

Gemifloxacin SB-265805; LB20304	Antibiotic Bacterial	Infection
Gemifloxacin, a fluoroquinolone, is a potent and orally active antipneumococcal agent. Gemifloxacin shows bactericidal activity against highly quinolone-resistant pneumococci.Gemifloxacin can be used for the research of respiratory infections, such as community-acquired pneumonia (CAP) and acute exacerbation of chronic bronchitis (AECB) ^[1] .

HY-145973

3'OMe-m7GpppAmpG m7(3'OMeG)(5')ppp(5')(2'OMeA)pG	DNA/RNA Synthesis	Others
3'OMe-m7GpppAmpG is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG shows a significant translational efficiency. 3'OMe-m7GpppAmpG can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization ^[1].

HY-RS17877

Cap1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cap1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cap1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cap1 Mouse Pre-designed siRNA Set A Cap1 Mouse Pre-designed siRNA Set A

HY-RS24346

Cap1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cap1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cap1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cap1 Rat Pre-designed siRNA Set A Cap1 Rat Pre-designed siRNA Set A

HY-178672

ARCA Anti-Reverse Cap analog; m2 7,3′O GpppG	DNA/RNA Synthesis	Cancer
ARCA (Anti-Reverse cap analog) is a 5′- cap analogue. ARCA caps mRNA. ARCA can be used in protein expression studies ^[1].

HY-113897

Chloramphenicol 3-acetate	Bacterial	Infection
Chloramphenicol 3-acetate is the main intermediate in the biodegradation of CAP, formed by the acetylation of the 3-hydroxy group of CAP through chloramphenicol acetyltransferase, this is a common resistance mechanism that microbes have against chloramphenicol ^[1].

HY-143769

Sebaloxavir marboxil Cap-dependent endonuclease-IN-15	Influenza Virus	Infection
Sebaloxavir marboxil (Cap-dependent endonuclease-IN-15) (Compound c-1) is a potent inhibitor of cap-dependent endonuclease (CEN). Sebaloxavir marboxil inhibits the replication of influenza virus. Sebaloxavir marboxil has the potential for the research of viral infections caused by influenza viruses ^[1].

HY-W129441

N-Acetyl-4-S-cysteaminylphenol N-Ac-4-S-Cap	DNA/RNA Synthesis Tyrosinase Thymidylate Synthase	Others
N-Acetyl-4-S-mercaptoaminophenol (N-Ac-4-S-CAP) is a compound that is selectively cytotoxic to melanocytes of black mouse hair follicles. It can cause 98% depigmentation of black mouse hair follicles. N-Ac-4-S-CAP can produce visible changes in hair follicle melanocytes 4 hours after intraperitoneal injection, including aggregation of melanin granules and nuclear condensation. Electron microscopy observations showed that it caused progressive destruction of melanocytes, including swelling of membranous organelles, nuclear condensation, and cytoplasmic vacuolation, ultimately leading to complete cell necrosis. N-Ac-4-S-CAP has a specific cytotoxic effect on melanocytes that actively produce eumelanin, but may not affect precursor or dormant melanocytes. These properties suggest that N-Ac-4-S-CAP may have potential application value in the treatment of melanoma or skin whitening.

HY-178146

*Mc-Lys(PEG12)-Cap-Ala-Ala-PABC*	ADC Linker	Cancer
Mc-Lys(PEG12)-Cap-Ala-Ala-PABC is a linker of MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan (HY-178146) ^[1].

HY-A0148AR

Halofantrine hydrochloride (Standard) SKF-102886 (Standard); WR-171669 hydrochloride (Standard)	Reference Standards Parasite Fungal Potassium Channel Reactive Oxygen Species (ROS)	Infection
Halofantrine hydrochloride (Standard) is the analytical standard of Halofantrine hydrochloride. This product is intended for research and analytical applications. Halofantrine hydrochloride (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent. Halofantrine hydrochloride inhibits the *Cap1*-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria.

HY-115693

CAP 3	Bacterial	Infection
CAP 3 is a cholic acid-peptide conjugate (CAP) antimicrobial agent. CAP 3 effectively inhibits Gram-negative bacteria, with MIC₉₉ (minimum inhibitory concentration for 99% bacterial killing) values of 8 μM, 16 μM, and 16 μM against E. coli, Klebsiella pneumoniae and Acinetobacter baumannii, respectively. CAP 3 exerts its antibacterial effects by disrupting the structural integrity of the bacterial lipopolysaccharide (LPS) outer membrane. CAP 3 rapidly kills bacteria, inhibits biofilm formation, and effectively combats drug-resistant strains and persistent bacterial infections ^[1].

HY-123702

CAP-53194	Polo-like Kinase (PLK)	Cancer
CAP-53194 is a selective Plk1 inhibitor with potential anticancer activity. CAP-53194 was identified by a high-throughput virtual screening approach using molecular docking, showing 100-fold selectivity for Plk1 over Plk2-4 and other cell cycle kinases. CAP-53194 is able to effectively exploit subtle differences between the binding sites of Plk1 and other Ser/Thr kinases, thereby enhancing their inhibitory effects. CAP-53194 meets the Lipinski compound analog criteria and passes other ADMET filters, indicating good compound compatibility. CAP-53194 belongs to a new class of potential Plk1 inhibitors suitable for subsequent compound development and testing ^[1].

HY-159855

CAP 2 hydrochloride Cholesterol-amino-phosphate 2 hydrochloride	Liposome	Others
CAP 2 (Cholesterol-amino-phosphate 2) hydrochloride is Cholesterol-amino-phosphate (CAP) lipid. CAP 2 can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads ^[1].

HY-143770

Cap-dependent endonuclease-IN-16	Influenza Virus	Infection
Cap-dependent endonuclease-IN-16 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-16 is a pyridone polycyclic derivative. Cap-dependent endonuclease-IN-16 has the potential for the research of influenza (extracted from patent CN112778330A, compound 15A) ^[1].

HY-143776

Cap-dependent endonuclease-IN-22	Influenza Virus	Infection
Cap-dependent endonuclease-IN-22 is a potent cap-dependent endonuclease (CEN) inhibitor ^[1].

HY-143781

Cap-dependent endonuclease-IN-26	Influenza Virus	Infection
Cap-dependent endonuclease-IN-26 is a cap-dependent endonuclease (CEN) inhibitor with an IC₅₀ of 286 nM. Cap-dependent endonuclease-IN-26 shows antiviral activity against many influenza A and B strains ^[1].

HY-144065

Cap-dependent endonuclease-IN-19	DNA/RNA Synthesis Influenza Virus	Infection
Cap-dependent endonuclease-IN-19 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-19 is a spirocyclic pyridone derivative. Cap-dependent endonuclease-IN-19 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent CN111410661A, compound 1) ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0086

N6-Methyladenosine Maximum Cited Publications 7 Publications Verification 6-Methyladenosine; N-Methyladenosine	Infection Natural Products Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Influenza Virus Endogenous Metabolite
N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-122524

7-Methylguanosine 2 Publications Verification	Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Nucleoside Antimetabolite/Analog Endogenous Metabolite DNA/RNA Synthesis
7-Methylguanosine is a modified nucleoside widely present in various RNAs and a key metabolite of the 5'-cap structure of eukaryotic mRNA. 7-Methylguanosine plays important roles in stabilizing RNA structures, regulating translation, and other aspects ^[1] .

HY-W087904

α-Lactose hydrate α-D-Lactose hydrate	Structural Classification Polysaccharides Animals Saccharides Source Classification	Endogenous Metabolite Biochemical Assay Reagents
α-Lactose hydrate (α-D-Lactose (hydrate)) is the primary carbohydrate in the milk of most mammals. α-Lactose hydrate consists of glucose and galactose and exists in two isomeric forms, α and β. α-Lactose hydrate has numerous applications in the food and pharmaceutical industries, such as serving as a bulking or agglomerating agent, and a diluent for pigments, flavors or enzymes ^[1].

HY-N2362

DL-Alanine DL-2-Aminopropionic acid	Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
DL-alanine, an orally active amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver ^[1] .

HY-107823

Cholesteryl acetate Cholesterol 3-acetate; Cholesterin acetate; Cholesterol 3β-acetate	Structural Classification Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Cholesteryl acetate (Cholesterol 3-acetate) is a cholesterol ester that is exported from Saccharomyces cerevisiae via a Pry1-dependent mechanism. Cholesteryl acetate binds to the CAP superfamily protein *Pry1* via interactions dependent on *Pry1*’s caveolin-binding motif ^[1] .

HY-141472

7-Methylguanosine 5'-diphosphate sodium 7-Methyl-GDP sodium; m7GDP sodium	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues ^[1].

HY-W012944

2-Methylcyclopentane-1,3-dione	Panax ginseng C. A. Meyer Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields Araliaceae Source Classification	Biochemical Assay Reagents
2-Methylcyclopentane-1,3-dione is a synthon . 2-Methylcyclopentane-1,3-dione can be used for the synthesis of (±)-α-cuparenone ^[1].

HY-N0086R

N6-Methyladenosine (Standard) 1 Publications Verification 6-Methyladenosine (Standard); N-Methyladenosine (Standard)	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite Influenza Virus Reference Standards
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion ^[1]. N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

HY-W001189

1,3-Dithiane	Infection Natural Products Animals Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Bacterial
1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against *S. typhimurium* TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon ^[1] .

HY-N6772

Cytochalasin E	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Source Classification Cancer	Autophagy
Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation ^[1] .

HY-N7647

Methyl brevifolincarboxylate Brevifolincarboxylic acid methyl ester	Infection Natural Products Classification of Application Fields Canarium album (Lour.) Rauesch. Plants Burseraceae Disease Research Fields Source Classification	Influenza Virus
Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate has anti-oxidant activity. Methyl brevifolincarboxylate also inhibits platelet aggregation, lipid metabolism and inflammation ^[1] .

HY-N15882

*16:0 DNP Cap* PE monoammonium**	Lipid	Biochemical Assay Reagents
16:0 DNP Cap PE monoammonium is an antigenic lipid that plays a role in promoting antigen presentation on lipid bilayers ^[1].

HY-W001189R

1,3-Dithiane (Standard)	Structural Classification Natural Products Animals Endogenous metabolite Source Classification	Reference Standards Bacterial
1,3-Dithiane (Standard) is an analytical standard of 1,3-Dithiane (HY-W001189). This product is intended for research and analytical applications. 1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against *S. typhimurium* TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon ^[1] .

HY-N15772

*16:0 Folate cap* PE disodium**	Structural Classification Lipid	Biochemical Assay Reagents
16:0 Folate cap PE is a lipid layer containing phospholipid surfactant. 16:0 Folate cap PE can be used to prepare lipid nanoparticles for drug delivery ^[1].

HY-W714077

(2R,3S)-3-Methylmalic acid	Structural Classification Natural Products Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
(2R,3S)-3-Methylmalic acid (compound 4b) is a synthon for 2-methyl-3-hydroxy-butyrolactones ^[1].

Cat. No.	Product Name	Chemical Structure

HY-N0086S

N6-Methyladenosine-d3
N6-Methyladenosine-d₃ (6-Methyladenosine-d₃; N-Methyladenosine-d₃) is a deuterium labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-N0086S2

N6-Methyladenosine-13C4
N6-Methyladenosine- ¹³C₄ (6-Methyladenosine- ¹³C₄; N-Methyladenosine- ¹³C₄) is ¹³C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-109025AS

Baloxavir-d5
Baloxavir-d₅ is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity ^[1] .

HY-N2362S2

DL-Alanine-d3

DL-Alanine-d₃ is the deuterium labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver ^[1] .

HY-W751835

Baloxavir-d4

Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity ^[1] .

HY-W001189S

1,3-Dithiane-d2
1,3-Dithiane-d2 is the deuterium labeled 1,3-Dithiane (HY-W001189). 1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against *S. typhimurium* TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon ^[1] .

HY-79096S2

BOC-L-phenylalanine-d8
BOC-L-phenylalanine-d₈ is the deuterium labeled BOC-L-phenylalanine (HY-79096). Boc-L-phenylalanine is a Boc-protected L-phenylalanine that can be used in the synthesis of other active compounds. Boc-L-phenylalanine is also a capping agent ^[1].

HY-79096S1

BOC-L-phenylalanine-d5
BOC-L-phenylalanine-d₅ is the deuterium labeled BOC-L-phenylalanine (HY-79096). Boc-L-phenylalanine is a Boc-protected L-phenylalanine that can be used in the synthesis of other active compounds. Boc-L-phenylalanine is also a capping agent ^[1].

HY-79096S

BOC-L-Phenylalanine-13C
BOC-L-Phenylalanine- ¹³C is a ¹³C-labeled BOC-L-Phenylalanine (HY-79096). Boc-L-phenylalanine is a Boc-protected L-phenylalanine that can be used in the synthesis of other active compounds. Boc-L-phenylalanine is also a capping agent ^[1].

HY-N0086S3

N6-Methyladenosine-13C3
N6-Methyladenosine- ¹³C₃ (6-Methyladenosine- ¹³C₃) is ¹³C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities ^[1] .

HY-W740028

Cefditoren-d3 sodium

Cefditoren-d₃ (sodium) (ME 1206-d₃) is deuterium labeled Cefditoren (sodium). Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections ^[1] .

HY-17452AS

Cefditoren pivoxil-d3

Cefditoren Pivoxil-d₃ (Cefditoren pivoxyl-d₃) is deuterium labeled Cefditoren Pivoxil. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections ^[1] .

HY-N2362S5

DL-Alanine-15N

DL-Alanine- ¹⁵N is the ¹⁵N labeled DL-Alanine ^[1]. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver .

HY-N2362S1

DL-Alanine-13C-3

DL-Alanine- ¹³C-3 is the ¹³C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver ^[1] .

HY-N2362S

DL-Alanine-13C-1

DL-Alanine- ¹³C-1 is the ¹³C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver ^[1] .

HY-N2362S8

DL-Alanine-d7

DL-Alanine-d₇ (DL-2-Aminopropionic acid-d₇) is deuterium labeled DL-Alanine. DL-alanine, an orally active amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver ^[1] .

HY-N2362S9

DL-Alanine-13C2,15N

DL-Alanine- ¹³C₂, ¹⁵N (DL-2-Aminopropionic acid- ¹³C₂, ¹⁵N) is ¹³C and ¹⁵N labeled DL-Alanine. DL-alanine, an orally active amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver ^[1] .

HY-D0869S

3-(Cyclohexylamino)-1-propanesulfonic Acid-d17
3-(Cyclohexylamino)-1-propanesulfonic Acid-d₁₇ is the deuterium labeled CAPS . CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis .

HY-122524AS1

7-Methylguanosine-13C iodide

7-Methylguanosine- ¹³C iodide is the ¹³C-labeled 7-Methylguanosine iodide (HY-122524A). 7-Methylguanosine iodide is an iodide of 7-Methylguanosine (HY-122524). 7-Methylguanosine is a modified nucleoside widely present in various RNAs and a key metabolite of the 5'-cap structure of eukaryotic mRNA. 7-Methylguanosine plays important roles in stabilizing RNA structures, regulating translation, and other aspects.

HY-122524AS

7-Methylguanosine-13C,d3 iodide

7-Methylguanosine- ¹³C,d₃ iodide is the ¹³C- and deuterium labeled 7-Methylguanosine iodide (HY-122524A). 7-Methylguanosine iodide is an iodide of 7-Methylguanosine (HY-122524). 7-Methylguanosine is a modified nucleoside widely present in various RNAs and a key metabolite of the 5'-cap structure of eukaryotic mRNA. 7-Methylguanosine plays important roles in stabilizing RNA structures, regulating translation, and other aspects.

HY-178673S

m7G(5')ppp(5')(2'OMeA)-d3 ammonium
m7G(5')ppp(5')(2'OMeA)-d₃ ammonium is a cap analog that can be used for the synthesis of mRNA.

HY-109025AS2

Baloxavir-d1
Baloxavir-d₁ is the deuterium labeled Baloxavir (HY-109025A). Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity ^[1] .

HY-N2362S7

DL-Alanine-13C3-4

DL-Alanine- ¹³C₃-4 (DL-2-Aminopropionic acid- ¹³C₃-4) is the ¹³C-labeled DL-Alanine (HY-N2362). DL-Alanine, an orally active amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver ^[1] .

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