Methyl brevifolincarboxylate  (Synonyms: Brevifolincarboxylic acid methyl ester)

Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate has anti-oxidant activity. Methyl brevifolincarboxylate also inhibits platelet aggregation, lipid metabolism and inflammation^{[1][2][4][5][6]}.

Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC₅₀ value of 8.9 μM^[2].
Methyl brevifolincarboxylate (10 and 30 μM) inhibits NO and TNF-α production in LPS stimulated macrophages^[2].
Methyl brevifolincarboxylate (1 and 10 μM) inhibits Norepinephrine (HY-13715)-induced contractions of rat aorta^[3].
Methyl brevifolincarboxylate (5 μM) inhibits platelet aggregation by 73.5%^[4].
Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC₅₀s of 27.16 μM and 33.41 μM^[5].
Methyl brevifolincarboxylate (10-80 μM, 48 h) reduces TG Levels in OA-Treated SK-HEP-1 Cells and Primary Murine Hepatocytes^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

306.22

C₁₄H₁₀O₈

154702-76-8

O=C(C1CC(C2=C1C3=C(O)C(O)=C(O)C=C3C(O2)=O)=O)OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wu QY, et al. Chromatographic fingerprint and the simultaneous determination of five bioactive components of geranium carolinianum L. water extract by high performance liquid chromatography. Int J Mol Sci. 2011;12(12):8740-8749.  [Content Brief]

  [2]. Fang SH, et al. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol. 2008;116(2):333-340.  [Content Brief]

  [3]. Iizuka T, et al. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol Pharm Bull. 2006 Jan;29(1):177-9.  [Content Brief]

  [4]. Iizuka T, et al. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol Pharm Bull. 2007 Feb;30(2):382-4.  [Content Brief]