Methyl brevifolincarboxylate
Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate has anti-oxidant activity. Methyl brevifolincarboxylate also inhibits platelet aggregation, lipid metabolism and inflammation.
For research use only. We do not sell to patients.
- CAS No.: 154702-76-8
- Formula: C14H10O8
- Molecular Weight:306.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Erythrocyte | IC50 |
1.04 mM
Compound: 13
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Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
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[PMID: 29631958] |
| Erythrocyte | IC50 |
1.26 mM
Compound: 13
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Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
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[PMID: 29631958] |
Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC50 value of 8.9 μM[2].
Methyl brevifolincarboxylate (10 and 30 μM) inhibits NO and TNF-α production in LPS stimulated macrophages[2].
Methyl brevifolincarboxylate (1 and 10 μM) inhibits Norepinephrine (HY-13715)-induced contractions of rat aorta[3].
Methyl brevifolincarboxylate (5 μM) inhibits platelet aggregation by 73.5%[4].
Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC50s of 27.16 μM and 33.41 μM[5].
Methyl brevifolincarboxylate (10-80 μM, 48 h) reduces TG Levels in OA-Treated SK-HEP-1 Cells and Primary Murine Hepatocytes[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SK-HEP-1 cells
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Concentration:10, 20, 40, 80 μM
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Incubation Time:48 h
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Result:Reduced the protein levels of FASN, SREBP-1c and ACC1.
Increased the expression of PPAR-α.
Chemical Information
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CAS No. 154702-76-8
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Molecular Weight 306.22
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Formula C14H10O8
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SMILES
O=C(C1CC(C2=C1C3=C(O)C(O)=C(O)C=C3C(O2)=O)=O)OC
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Synonyms
Brevifolincarboxylic acid methyl ester
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wu QY, et al. Chromatographic fingerprint and the simultaneous determination of five bioactive components of geranium carolinianum L. water extract by high performance liquid chromatography. Int J Mol Sci. 2011;12(12):8740-8749. [Content Brief]
[2]. Fang SH, et al. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol. 2008;116(2):333-340. [Content Brief]
[3]. Iizuka T, et al. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol Pharm Bull. 2006 Jan;29(1):177-9. [Content Brief]
[4]. Iizuka T, et al. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol Pharm Bull. 2007 Feb;30(2):382-4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Methyl brevifolincarboxylate Related Classifications
HY-N7647 Related Classifications
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