Pixavir marboxil
Based on 1 Customer Validation
Pixavir marboxilo (TG-1000) is an orally active prodrug of TG-0527 and an analog of Baloxavir marboxil (HY-109025). Pixavir marboxilo undergoes conversion to its active metabolite and inhibits the cap‑dependent endonuclease of Influenza Virus, reduces pulmonary viral titers, and suppresses the proliferation of influenza A, influenza B, H7N9 avian influenza, and neuraminidase‑resistant strains. Pixavir marboxilo can be used in influenza-related research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.53%
- CAS No.: 2365473-17-0
- Formule: C27H22F2N2O6S
- Masse moléculaire:540.54
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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Influenza hemagglutinin (HA) |
In Vitro
Pixavir marboxilo, via its active metabolite, inhibits influenza A/H1N1, A/H3N2, and influenza B viral replication in MDCK cells with EC50 values of 0.35-1.94 nM, 0.91-3.09 nM, and 2.75-11.90 nM respectively, and selects for reduced-susceptibility influenza A/H1N1 isolates with specific PA protein mutations[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2365473-17-0
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Appearance Solid
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Masse moléculaire 540.54
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Formule C27H22F2N2O6S
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Color White to off-white
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SMILES
O=C1C2(CC2)CN([C@@]3([H])C4=CC=C(F)C(F)=C4CSC5=CC=CC=C53)N6C1=C(C(C=C6)=O)OCOC(OC)=O
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Synonyms
TG-1000
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (185.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (300 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8500 mL | 9.2500 mL | 18.5000 mL | 46.2500 mL |
| 5 mM | 0.3700 mL | 1.8500 mL | 3.7000 mL | 9.2500 mL | |
| 10 mM | 0.1850 mL | 0.9250 mL | 1.8500 mL | 4.6250 mL | |
| 15 mM | 0.1233 mL | 0.6167 mL | 1.2333 mL | 3.0833 mL | |
| 20 mM | 0.0925 mL | 0.4625 mL | 0.9250 mL | 2.3125 mL | |
| 25 mM | 0.0740 mL | 0.3700 mL | 0.7400 mL | 1.8500 mL | |
| 30 mM | 0.0617 mL | 0.3083 mL | 0.6167 mL | 1.5417 mL | |
| 40 mM | 0.0463 mL | 0.2313 mL | 0.4625 mL | 1.1563 mL | |
| 50 mM | 0.0370 mL | 0.1850 mL | 0.3700 mL | 0.9250 mL | |
| 60 mM | 0.0308 mL | 0.1542 mL | 0.3083 mL | 0.7708 mL | |
| 80 mM | 0.0231 mL | 0.1156 mL | 0.2313 mL | 0.5781 mL | |
| 100 mM | 0.0185 mL | 0.0925 mL | 0.1850 mL | 0.4625 mL |
Pixavir marboxil Related Classifications
HY-132894 Related Classifications
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Keywords
- Pixavir marboxil
- 2365473-17-0
- TG-1000
- TG1000
- TG 1000
- Drug Intermediate
- Influenza Virus
- Endonuclease
- Drug Iintermediate
- MDCK cells
- influenza virus
- influenza B
- influenza A
- PA protein endonuclease
- P-gp
- CYP enzymes
- neuraminidase-resistant strains
- H7N9 avian influenza
- cap-dependent nucleic acid endonuclease
- Inhibitor
- inhibitor
- inhibit