3'OMe-m7GpppAmpG Tris 

3'OMe-m7GpppAmpG (Tris) is a trinucleotide Cap1 analog with the structure m7 (3'OMeG)(5') ppp (5')(2'OMeA) pG, and also functions as a cis-acting ligase ribozyme inhibitor. 3'OMe-m7GpppAmpG (Tris) effectively reduces free 5'-triphosphate groups on RNA transcripts, thereby enabling efficient co-transcriptional capping of in vitro transcribed mRNA. 3'OMe-m7GpppAmpG (Tris) is not only widely used in the preparation of modified mRNA including trivalent influenza vaccine candidates, but also applicable to studies related to SARS-CoV-2 infection and other relevant research^[1][2][3][4].

3'OMe-m7GpppAmpG (Tris) (4 mM; 2 h) supports the production of translationally active HA-encoding mRNA that expresses functional HA protein in HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1523.10

C₄₅H₇₈N₁₈O₃₃P₄

OCC(CO)([NH3+])CO.OCC(CO)([NH3+])CO.OCC(CO)([NH3+])CO.NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OC)[C@H](OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4O)([O-])=O)[C@@H](COP(OP(OP(OC[C@H]7O[C@@H](N(C=[N+]8C)C9=C8C(NC(N)=N9)=O)[C@H](O)[C@@H]7OC)([O-])=O)([O-])=O)([O-])=O)O3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mazunina EP, et al. Trivalent mRNA vaccine-candidate against seasonal flu with cross-specific humoral immune response. Front Immunol. 2024;15:1381508. Published 2024 Apr 16.

  [2]. Su C I, et al. A cis-acting ligase ribozyme generates circular RNA in vitro for ectopic protein functioning[J]. Nature Communications, 2024, 15(1): 6607.

  [3]. Tusup M, et al. Design of in vitro transcribed mRNA vectors for research and therapy[J]. Chimia, 2019, 73(5): 391-391.

  [4]. Kim S, et al. Innate immune responses against mRNA vaccine promote cellular immunity through IFN-β at the injection site[J]. Nature communications, 2024, 15(1): 7226.