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Cat. No.: HY-145973B

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3'OMe-m7GpppAmpG Tris

3'OMe-m7GpppAmpG (Tris) is a trinucleotide Cap1 analog with the structure m7 (3'OMeG)(5') ppp (5')(2'OMeA) pG, and also functions as a cis-acting ligase ribozyme inhibitor. 3'OMe-m7GpppAmpG (Tris) effectively reduces free 5'-triphosphate groups on RNA transcripts, thereby enabling efficient co-transcriptional capping of in vitro transcribed mRNA. 3'OMe-m7GpppAmpG (Tris) is not only widely used in the preparation of modified mRNA including trivalent influenza vaccine candidates, but also applicable to studies related to SARS-CoV-2 infection and other relevant research.

For research use only. We do not sell to patients.

Formula: C₄₅H₇₈N₁₈O₃₃P₄
Molecular Weight:1523.10

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

3'OMe-m7GpppAmpG Tris Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

3'OMe-m7GpppAmpG (Tris) (4 mM; 2 h) supports the production of translationally active HA-encoding mRNA that expresses functional HA protein in HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1523.10
Formula C₄₅H₇₈N₁₈O₃₃P₄
SMILES

OCC(CO)([NH3+])CO.OCC(CO)([NH3+])CO.OCC(CO)([NH3+])CO.NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OC)[C@H](OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4O)([O-])=O)[C@@H](COP(OP(OP(OC[C@H]7O[C@@H](N(C=[N+]8C)C9=C8C(NC(N)=N9)=O)[C@H](O)[C@@H]7OC)([O-])=O)([O-])=O)([O-])=O)O3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mazunina EP, et al. Trivalent mRNA vaccine-candidate against seasonal flu with cross-specific humoral immune response. Front Immunol. 2024;15:1381508. Published 2024 Apr 16. [Content Brief]

[2]. Su C I, et al. A cis-acting ligase ribozyme generates circular RNA in vitro for ectopic protein functioning[J]. Nature Communications, 2024, 15(1): 6607.

[3]. Tusup M, et al. Design of in vitro transcribed mRNA vectors for research and therapy[J]. Chimia, 2019, 73(5): 391-391.

[4]. Kim S, et al. Innate immune responses against mRNA vaccine promote cellular immunity through IFN-β at the injection site[J]. Nature communications, 2024, 15(1): 7226.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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