2. Anti-infection
  3. HBV
  4. 2'-Deoxy-L-adenosine

2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV).

For research use only. We do not sell to patients.

2'-Deoxy-L-adenosine

2'-Deoxy-L-adenosine Chemical Structure

CAS No. : 14365-45-8

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2'-Deoxy-L-adenosine Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV)[1].

In Vitro

2'-Deoxy-L-adenosine shows anti-hepadnavirus activity, withour affecting the replication of 15 other RNA and DNA viruses, neither nor inhibiting human DNA polymerases (α, β, and γ) or compromise mitochondrial function[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2'-Deoxy-L-adenosine Related Antibodies
In Vivo

2'-Deoxy-L-adenosine (p.o.; once daily) reduces viral load by as much as 108 genome equivalent/mL serum without drug-related toxicity in woodchuck efficacy model of chronic HBV infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

251.24

Formula

C10H13N5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=NC2=C1N=CN2[C@@H]3C[C@@H](O)[C@H](CO)O3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (124.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9803 mL 19.9013 mL 39.8026 mL
5 mM 0.7961 mL 3.9803 mL 7.9605 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9803 mL 19.9013 mL 39.8026 mL 99.5064 mL
5 mM 0.7961 mL 3.9803 mL 7.9605 mL 19.9013 mL
10 mM 0.3980 mL 1.9901 mL 3.9803 mL 9.9506 mL
15 mM 0.2654 mL 1.3268 mL 2.6535 mL 6.6338 mL
20 mM 0.1990 mL 0.9951 mL 1.9901 mL 4.9753 mL
25 mM 0.1592 mL 0.7961 mL 1.5921 mL 3.9803 mL
30 mM 0.1327 mL 0.6634 mL 1.3268 mL 3.3169 mL
40 mM 0.0995 mL 0.4975 mL 0.9951 mL 2.4877 mL
50 mM 0.0796 mL 0.3980 mL 0.7961 mL 1.9901 mL
60 mM 0.0663 mL 0.3317 mL 0.6634 mL 1.6584 mL
80 mM 0.0498 mL 0.2488 mL 0.4975 mL 1.2438 mL
100 mM 0.0398 mL 0.1990 mL 0.3980 mL 0.9951 mL
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2'-Deoxy-L-adenosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Deoxy-L-adenosine14365-45-8HBVHepatitis B virusoligodeoxyribonucleotidesviral enzymedeoxyadenosinehepatitis viruseshepatitis B virusWHVanti-hepadnavirus activitywoodchuck efficacy model of chronic HBV infectionInhibitorinhibitorinhibit

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