CAPG Protein, Human
Based on 1 Customer Validation
Macrophage-capping protein (CAPG), a ubiquitous actin-binding protein, belongs to the gelsolin/villin superfamily and is associated with cell motility. CAPG is a Ca2+-sensitive protein and plays a role in macrophage function and is involved in the process of metastasis by promoting the invasiveness of tumor cells. CAPG Protein, Human is the recombinant human-derived CAPG protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Macrophage-capping protein (CAPG), a ubiquitous actin-binding protein, belongs to the gelsolin/villin superfamily and is associated with cell motility. CAPG is a Ca2+-sensitive protein and plays a role in macrophage function and is involved in the process of metastasis by promoting the invasiveness of tumor cells[1][2][3]. CAPG Protein, Human is the recombinant human-derived CAPG protein, expressed by E. coli , with tag free.
Macrophage-capping protein (CAPG), a ubiquitous actin-binding protein, belongs to the gelsolin/villin superfamily and is associated with cell motility. CAPG is a Ca2+-sensitive protein and plays a role in macrophage function and cancer progression[1][2]. Besides, CapG expression is elevated in kinds of cancer, such as HCC, pancreatic cancer and breast cancer. CapG is involved in the process of metastasis by promoting the invasiveness of tumor cells[3].
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
AAH14549 (M1-K348)
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Molecular Construction
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N-term
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CAPG (M1-K348)
Accession # AAH14549 -
C-term
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Protein Length
Full Length
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Synonyms
Macrophage-capping protein; Actin regulatory protein CAP-G; CAPG; AFCP; MCP
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AA Sequence
MYTAIPQSGSPFPGSVQDPGLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAPAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFISRMQYAPNTQVEILPQGRESPIFKQFFKDWK
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Molecular Weight
Approximately 43 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
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≥ 95%, as determined by reducing SDS-PAGE.
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Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of 50 mM Tris-HCl, 200 mM NaCl, pH 8.0, 8% trehalose.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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