CAPG - capping actin protein, gelsolin like Gene

Homo sapiens

Also known as MCP; AFCP; HEL-S-66

Gene ID: 822 | Gene type: protein coding

About CAPG

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,391,602-85,419,540 (from NCBI)

This gene has 15 transcripts (splice variants), 211 orthologues and 7 paralogues. Broad expression in lung (RPKM 44.7), esophagus (RPKM 37.5) and 22 other tissues.

Summary

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]

CAPG Products(6)

mRNA	Protein	Name
NM_001256139.2	NP_001243068.1	macrophage-capping protein isoform 1
NM_001256140.2	NP_001243069.1	macrophage-capping protein isoform 2
NM_001320732.2	NP_001307661.1	macrophage-capping protein isoform 1
NM_001320733.2	NP_001307662.1	macrophage-capping protein isoform 1
NM_001320734.2	NP_001307663.1	macrophage-capping protein isoform 3
NM_001747.4	NP_001738.2	macrophage-capping protein isoform 1

Protein Preferred Names

Protein Names

macrophage-capping protein

actin-regulatory protein CAP-G

Recombinant CAPG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75601	CAPG Protein, Human	AAH14549 (M1-K348)	≥95%

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01882	CAPG Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CAPG	VGNC	VGNC:26739
Canis familiaris	CAPG	VGNC	VGNC:38697
Macaca mulatta	CAPG	VGNC	VGNC:70528
Rattus norvegicus	CAPG	RGD	RGD:1311724
Felis catus	CAPG	VGNC	VGNC:80045
Mus musculus	CAPG	MGD	MGI:1098259
Others	CAPG	NCBI