Cap-dependent endonuclease-IN-26
Cap-dependent endonuclease-IN-26 is a cap-dependent endonuclease (CEN) inhibitor with an IC50 of 286 nM. Cap-dependent endonuclease-IN-26 shows antiviral activity against many influenza A and B strains.
For research use only. We do not sell to patients.
- CAS No.: 1370238-26-8
- Formula: C23H23N3O3
- Molecular Weight:389.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | CC50 |
>25 μM
Compound: 2v
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Cytotoxicity against MDCK cells after 3 days by WST-8 assay
Cytotoxicity against MDCK cells after 3 days by WST-8 assay
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[PMID: 31386363] |
Cap-dependent endonuclease-IN-26 (compound 2v) exhibits broad antiviral spectrum. Cap-dependent endonuclease-IN-26 shows antiviral activity against the H1N1 type, including the reverse genetic strain (rgA/WSN/33), oseltamivir-resistant strain (rgA/WSN/33-NA/H274Y), clinically isolated strain (A/PR/8/34), H3N2 A/Victoria/3/75, H3N2 A/HongKong/8/68, influenza B/Hong Kong/5/72, and influenza B/Maryland/1/59 with EC50 values 165.1 nM, 80.4 nM, 183.0 nM, 828.8 nM, 301.5 nM, 124.3 nM, and 176.0 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In a mouse influenza B (B/Maryland/1/59) model, Cap-dependent endonuclease-IN-26 (compound 2v; intravenous administration; 0.08-10 mg/kg; q.d.;1 day) shows dose-dependent efficacy in an immediate treatment model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1370238-26-8
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Molecular Weight 389.45
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Formula C23H23N3O3
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SMILES
O=C1N(C(C)C)CN(C(C2=CC=CC=C2)C3=CC=CC=C3)N4C1=C(O)C(C=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cap-dependent endonuclease-IN-26 Related Classifications
HY-143781 Related Classifications
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