PDZK1 Antibody (YA1571)(PBS only)
(Synonyms: CAP70; CLAMP; PDZD1; NHERF3; NHERF-3)PDZK1 Antibody (YA1571) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDZK1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:20 |
Product Details
PDZK1 Antibody (YA1571) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDZK1.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 70 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 57 kDa
A synthetic peptide of human PDZK1 aa 474-486.
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PDZK1 is an A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function
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Subcellular Localization
Membrane; Peripheral membrane protein; Cell membrane
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Expression
Tissue_specificity:Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule) , pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas -
Isoforms & Post-Translational Modification
Q5T2W1 has 2 isomers: Q5T2W1-1: 57129 Da (predicted); Q5T2W1-2: 44665 Da (predicted).
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Subunit
Interacts with PDZK1IP1 and ABCC2. Interacts (via PDZ domains 1 and 3) with SCARB1 (C-terminal domain).
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SwissProt ID
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Synonyms
CAP70; CLAMP; PDZD1; NHERF3; NHERF-3
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Research Field
Signal Transduction
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