M7G (3'-OMe-5') pppA (2'-OMe)
M7G (3'-OMe-5') pppA (2'-OMe) is a modified cap analog. M7G (3'-OMe-5') pppA (2'-OMe) enhances the stability and translation efficiency of mRNA by maintaining the correct orientation of the mRNA cap, promoting cap-dependent translation initiation, and mimicking the Cap-1 structure to reduce immunogenicity. M7G (3'-OMe-5') pppA (2'-OMe) can be used in molecular biology research, vaccine development, and gene therapy applications.
For research use only. We do not sell to patients.
- CAS No.: 3047739-39-6
- Formula: C23H33N10O17P3
- Molecular Weight:814.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
M7G (3'-OMe-5') pppA (2'-OMe) (2 h) enables the synthesis of mRNA with predominantly forward cap structure, extremely high relative translation efficiency, strong stability and low immunogenicity during in vitro transcription reactions with phage RNA polymerase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3047739-39-6
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Molecular Weight 814.49
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Formula C23H33N10O17P3
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OC)[C@H](O)[C@@H](COP(OP(OP(OC[C@H]4O[C@@H](N(C=[N+]5C)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4OC)([O-])=O)(O)=O)(O)=O)O3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
M7G (3'-OMe-5') pppA (2'-OMe) Related Classifications
HY-147339 Related Classifications
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Keywords
- M7G (3'-OMe-5') pppA (2'-OMe)
- 3047739-39-6
- DNA/RNA Synthesis
- mRNA
- intracellular pattern recognition receptors
- bacteriophage RNA polymerases
- gene therapy
- cap-dependent translation
- eukaryotic Cap-1 structure
- in vitro mRNA transcription
- vaccine development
- m7G moiety
- translation initiation factor
- Inhibitor
- inhibitor
- inhibit