CAP m7G(5')ppp(5')(2'OMeG)
CAP m7G(5')ppp(5')(2'OMeG) is a dinucleotide cap analog that can be used as a monomeric raw material for nucleic acid synthesis. CAP m7G(5')ppp(5')(2'OMeG) can be synthesized from 2'-O-Methyl-GDP and 7-Methylguanosine under the catalysis of guanylate transferase, and can be used as an intermediate to synthesize Cap2 structure trinucleotide cap analogs. Research on the synthesis of CAP m7G(5')ppp(5')(2'OMeG) for mRNA cap analogs is underway.
For research use only. We do not sell to patients.
- CAS No.: 2222465-34-9
- Formula: C22H31N10O18P3
- Molecular Weight:816.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CAP m7G(5')ppp(5')(2'OMeG) is synthesized from 2'-O-Methyl-GDP and 7-Methylguanosine at 37°C for 1 h catalyzed by guanylate transferase[1].
CAP m7G(5')ppp(5')(2'OMeG) is purified by HPLC and then ligated with 2'-O-Methyl-GTP at 37°C for 1 h catalyzed by T4 RNA Ligase 1 to generate the Cap2 cap analog m7G(5')ppp(5')(2'OMeG)p(2'OMeG)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2222465-34-9
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Molecular Weight 816.46
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Formula C22H31N10O18P3
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SMILES
O[C@H]1[C@@H](OC)[C@H](N2C3=C(C(N=C(N3)N)=O)N=C2)O[C@@H]1COP(OP(OP(OC[C@H]4[C@H](O)[C@H](O)[C@@H](N5C6=C(C(N=C(N6)N)=O)[N+](C)=C5)O4)([O-])=O)(O)=O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAP m7G(5')ppp(5')(2'OMeG) Related Classifications
HY-178602 Related Classifications
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- CAP m7G(5')ppp(5')(2'OMeG)
- 2222465-34-9
- Nucleoside Antimetabolite/Analog
- mRNA cap analog
- cap structure
- Cap1
- dinucleotide cap analog
- 7-methylguanosine
- 2'-O-methylguanosine
- 5'-5' triphosphate bridge
- in vitro transcription
- co-transcriptional capping
- mRNA synthesis
- mRNA vaccine
- mRNA therapeutics
- gene editing
- cap analog intermediate
- Cap2 precursor
- Inhibitor
- inhibitor
- inhibit