CHVB-032
CHVB-032 is an antiviral agent and SFV nsP1 inhibitor. CHVB-032 inhibits the methyltransferase and guanylyltransferase activities of nsP1, blocks viral RNA capping process, and suppresses post-entry steps in CHIKV replication. CHVB-032 inhibits CHIKV replication across different isolates, but shows no activity against other alphaviruses. CHVB-032 can be used in research related to chikungunya fever and CHIKV infection.
For research use only. We do not sell to patients.
- CAS No.: 1309199-66-3
- Formula: C18H22FN5O
- Molecular Weight:343.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
CHVB-032 potently and selectively inhibits the replication of CHIKV 899 in Vero cells, with an EC50 of 2.7 µM and a CC50 greater than 75 µM[1].
CHVB-032 inhibits viral RNA replication of various CHIKV isolates in Vero cells, with EC50 values ranging from 1.2 to 7.3 µM, but shows no activity against other tested alphaviruses[1].
CHVB-032 (50-1000 µM; 30 min) completely inhibits both MTase and GTase activities of purified wild-type SFV nsP1 at concentrations ranging from 50 to 1000 µM[1].
CHVB-032 potently inhibits the replication of CHIKV-899 in Vero cells, with an EC50 of 2.7 μM and a CC50 greater than 75 μM[2].
CHVB-032 (0.63-20.00 μM) reduces viral RNA levels of CHIKV-899 and production of infectious progeny viruses in Vero cells in a dose-dependent manner in vitro, with a reduction of over 4-log10 at the highest tested concentration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero cells
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Concentration:20 µM
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Incubation Time:added at 0, 2, 4, 6, 8, 10 h post-infection
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Result:Reduced viral RNA and infectious virus loads when added up to 4 hours post-infection, indicating inhibition of a postentry step in the CHIKV replication cycle.
Chemical Information
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CAS No. 1309199-66-3
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Molecular Weight 343.40
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Formula C18H22FN5O
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SMILES
O=C(N1CCN(CC1)C2=NC(NCC)=NC(C)=C2)C3=CC=C(C=C3)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Abdelnabi R, et al. Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery. Antimicrob Agents Chemother. 2020;64(7):e00649-20. Published 2020 Jun 23. [Content Brief]
[3]. Kovacikova K, et al. Small-Molecule Inhibitors of Chikungunya Virus: Mechanisms of Action and Antiviral Drug Resistance. Antimicrob Agents Chemother. 2020;64(12):e01788-20. Published 2020 Nov 17. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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