2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis CHIKV
  4. CHVB-032

CHVB-032 is an antiviral agent and SFV nsP1 inhibitor. CHVB-032 inhibits the methyltransferase and guanylyltransferase activities of nsP1, blocks viral RNA capping process, and suppresses post-entry steps in CHIKV replication. CHVB-032 inhibits CHIKV replication across different isolates, but shows no activity against other alphaviruses. CHVB-032 can be used in research related to chikungunya fever and CHIKV infection.

For research use only. We do not sell to patients.

CHVB-032

CHVB-032 Chemical Structure

CAS No. : 1309199-66-3

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CHVB-032 Related Antibodies

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Description

CHVB-032 is an antiviral agent and SFV nsP1 inhibitor. CHVB-032 inhibits the methyltransferase and guanylyltransferase activities of nsP1, blocks viral RNA capping process, and suppresses post-entry steps in CHIKV replication. CHVB-032 inhibits CHIKV replication across different isolates, but shows no activity against other alphaviruses. CHVB-032 can be used in research related to chikungunya fever and CHIKV infection[1][2][3].

In Vitro

CHVB-032 potently and selectively inhibits the replication of CHIKV 899 in Vero cells, with an EC50 of 2.7 µM and a CC50 greater than 75 µM[1].
CHVB-032 inhibits viral RNA replication of various CHIKV isolates in Vero cells, with EC50 values ranging from 1.2 to 7.3 µM, but shows no activity against other tested alphaviruses[1].
CHVB-032 (50-1000 µM; 30 min) completely inhibits both MTase and GTase activities of purified wild-type SFV nsP1 at concentrations ranging from 50 to 1000 µM[1].
CHVB-032 potently inhibits the replication of CHIKV-899 in Vero cells, with an EC50 of 2.7 μM and a CC50 greater than 75 μM[2].
CHVB-032 (0.63-20.00 μM) reduces viral RNA levels of CHIKV-899 and production of infectious progeny viruses in Vero cells in a dose-dependent manner in vitro, with a reduction of over 4-log10 at the highest tested concentration[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CHVB-032 Related Antibodies

Real Time qPCR[1]

Cell Line: Vero cells
Concentration: 20 µM
Incubation Time: added at 0, 2, 4, 6, 8, 10 h post-infection
Result: Reduced viral RNA and infectious virus loads when added up to 4 hours post-infection, indicating inhibition of a postentry step in the CHIKV replication cycle.
Molecular Weight

343.40

Formula

C18H22FN5O
CAS No.
SMILES

O=C(N1CCN(CC1)C2=NC(NCC)=NC(C)=C2)C3=CC=C(C=C3)F
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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CHVB-032 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHVB-0321309199-66-3CHVB032CHVB 032DNA/RNA SynthesisCHIKVChikungunya virusalphavirus nonstructural protein 1VEEVnsP1methyltransferaseVero cellsguanylyltransferaseVeroE6 cellsBGM cellsSFVInhibitorinhibitorinhibit

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