Trifluoromethyl-tubercidin
Based on 2 publication(s) in Google Scholar
Trifluoromethyl-tubercidin (TFMT) is an inhibitor of 2'-O-ribose methyltransferase 1 (MTr1). Trifluoromethyl-tubercidin can inhibit the replication of influenza A and B viruses by interfering with the cap-snatching process of the influenza virus. Trifluoromethyl-tubercidin has antiviral activity and low toxicity.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 1854086-05-7
- Formula: C12H13F3N4O4
- Molecular Weight:334.25
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Trifluoromethyl-tubercidin
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Biological Activity
Trifluoromethyl-tubercidin (0-10 μM; 27 h) significantly inhibits the replication of IAV and IBV, but has no significant effect on the replication of HAZV and STBV in A549 cells infected with IAV, IBV, HAZV, and STBV[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells were infected with IAV, IBV, HAZV and STBV
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Concentration:0, 5 and 10 μM
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Incubation Time:Pretreated with 3 h, then co-incubation for 24 h
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Result:Inhibited IAV and IBV viral RNA levels and had no significant effect on HAZV and STBV viral RNA levels.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice were infected with IAV[1]
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Dosage:2 mg/kg
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Administration:Intranasally administered once a day for 2 days
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Result:Did not cause weight loss or cytotoxicity in the lungs of the mice.
Significantly reduced the mRNA levels of NP and PB2 in the mouse lungs at 2 days after IAV infection, indicating that TFMT retained anti-IAV efficacy in vivo without obvious toxicity.
Chemical Information
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CAS No. 1854086-05-7
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Appearance Solid
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Molecular Weight 334.25
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Formula C12H13F3N4O4
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O[C@@H]([C@H]1O)CO)N2C3=NC=NC(N)=C3C(C(F)(F)F)=C2
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Synonyms
TFMT
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
Solvent & Solubility
DMSO : 3.34 mg/mL (9.99 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9918 mL | 14.9589 mL | 29.9177 mL | 74.7943 mL |
| 5 mM | 0.5984 mL | 2.9918 mL | 5.9835 mL | 14.9589 mL |
Trifluoromethyl-tubercidin Related Classifications
HY-156048 Related Classifications
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