1. Epigenetics
    TGF-beta/Smad
    Cell Cycle/DNA Damage
  2. PKC
    Nucleoside Antimetabolite/Analog
  3. Sangivamycin

Sangivamycin (Synonyms: NSC 65346; BA-90912)

Cat. No.: HY-118384 Purity: 97.06%
Handling Instructions

Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers.

For research use only. We do not sell to patients.

Sangivamycin Chemical Structure

Sangivamycin Chemical Structure

CAS No. : 18417-89-5

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1 mg USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers[1][2].

In Vitro

Sangivamycin has differential antitumor effects in drug-sensitive MCF7/wild type (WT) cells, causing growth arrest, and in multidrug-resistant MCF7/adriamycin-resistant (ADR) human breast carcinoma cells, causing massive apoptotic cell death[2].
Sangivamycin (0.3 μM; 0-72 hours), shows almost maximal cytocidal (for MCF7/ADR) or cytostatic (for MCF7/WT) effects[2].
Sangivamycin activates caspases in MCF7/ADR cells. Upon exposure of MCF7/ADR cells to Sangivamycin (0.3 μM;), a vast amount of cleavage of lamin A to a 28-kDa fragment is detected within 48 hours[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

309.28

Formula

C₁₂H₁₅N₅O₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Sangivamycin
Cat. No.:
HY-118384
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