2. Cell Cycle/DNA Damage Anti-infection
  3. Endonuclease Influenza Virus
  4. Suraxavir marboxil

Suraxavir marboxil  (Synonyms: GP681; Cap-dependent endonuclease-IN-3)

Cat. No.: HY-143744
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Suraxavir marboxil (GP681; Cap-dependent endonuclease-IN-3) is a PA subunit cap-dependent endonuclease inhibitor with antiviral activity. Suraxavir marboxil inhibits PA subunit cap-dependent endonuclease activity and inhibits influenza A and/or influenza B viral replication. Suraxavir marboxil can be used alone or in combination with other anti-influenzal agents for the prevention of influenza A and/or influenza B viral infectious diseases. Suraxavir marboxil can be used for the research of influenza A and/or influenza B viral infectious diseases.

For research use only. We do not sell to patients.

Suraxavir marboxil

Suraxavir marboxil Chemical Structure

CAS No. : 2364589-86-4

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Based on 1 publication(s) in Google Scholar

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Description

Suraxavir marboxil (GP681; Cap-dependent endonuclease-IN-3) is a PA subunit cap-dependent endonuclease inhibitor with antiviral activity. Suraxavir marboxil inhibits PA subunit cap-dependent endonuclease activity and inhibits influenza A and/or influenza B viral replication. Suraxavir marboxil can be used alone or in combination with other anti-influenzal agents for the prevention of influenza A and/or influenza B viral infectious diseases. Suraxavir marboxil can be used for the research of influenza A and/or influenza B viral infectious diseases[1].

Parmacokinetics
Species Dose Route T1/2 Tmax Cmax AUC0-t F
Rat[1] 3.0 mg/kg i.g. 3.32 h 1.67 h 253 ng/mL 1377 ng·h/mL 47.2 %
In Vivo

Suraxavir marboxil (Compound III-2) (15 mg/kg; p.o.; daily for 5 days) achieves a statistically significant reduction in lung influenza virus titers in BALB/c mice infected with A/WS/33 (H1N1) virus[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice infected with A/WS/33 (H1N1) virus[1]
Dosage: 15 mg/kg
Administration: P.o.; daily for 5 days
Result: Achieved a statistically significant reduction in lung influenza virus titers.
Increased survival rate to 100%.
Clinical Trial
Molecular Weight

597.59

Formula

C29H25F2N3O7S
CAS No.
SMILES

O=C1N2[C@](COC3(CC3)C2)([H])N([C@@]4([H])C5=CC=C(F)C(F)=C5CSC6=CC=CC=C64)N7C1=C(C(C=C7)=O)OCOC(OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Suraxavir marboxil Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Suraxavir marboxil2364589-86-4GP681 Cap-dependent endonuclease-IN-3GP 681GP-681EndonucleaseInfluenza Virusinfluenza B viralinfluenza A virallung influenza virusBALB/c micePA subunit cap-dependent endonucleaseA/WS/33 (H1N1) virusInhibitorinhibitorinhibit

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