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製品番号: HY-143744

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Suraxavir marboxil

Name: Suraxavir marboxil
Brand: MedChemExpress
SKU: HY-143744
Price: 820.00 USD
Availability: PreOrder

(別名: GP681; Cap-dependent endonuclease-IN-3)

Suraxavir marboxil (GP681; Cap-dependent endonuclease-IN-3) is a PA subunit cap-dependent endonuclease inhibitor with antiviral activity. Suraxavir marboxil inhibits PA subunit cap-dependent endonuclease activity and inhibits influenza A and/or influenza B viral replication. Suraxavir marboxil can be used alone or in combination with other anti-influenzal agents for the prevention of influenza A and/or influenza B viral infectious diseases. Suraxavir marboxil can be used for the research of influenza A and/or influenza B viral infectious diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2364589-86-4
分子式: C₂₉H₂₅F₂N₃O₇S
分子量:597.59

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Suraxavir marboxil 構造式

CAS 番号: 2364589-86-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Parmacokinetics
- 体内実験
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	F
Rat^[1]	3.0 mg/kg	i.g.	3.32 h	1.67 h	253 ng/mL	1377 ng·h/mL	47.2 %

体内実験

Suraxavir marboxil (Compound III-2) (15 mg/kg; p.o.; daily for 5 days) achieves a statistically significant reduction in lung influenza virus titers in BALB/c mice infected with A/WS/33 (H1N1) virus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice infected with A/WS/33 (H1N1) virus^[1]
Dosage:

15 mg/kg
Administration:

P.o.; daily for 5 days
Result:

Achieved a statistically significant reduction in lung influenza virus titers.
Increased survival rate to 100%.

Related Protocols :

Research Protocol for Infectious Diseases

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 2364589-86-4
分子量 597.59
分子式 C₂₉H₂₅F₂N₃O₇S
SMILES

O=C1N2[C@](COC3(CC3)C2)([H])N([C@@]4([H])C5=CC=C(F)C(F)=C5CSC6=CC=CC=C64)N7C1=C(C(C=C7)=O)OCOC(OC)=O
別名

GP681; Cap-dependent endonuclease-IN-3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (275 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Li Chen, et al. Pyridone derivative, composition thereof and application thereof as anti-influenza drug. WO2019141179A1. 2020-07-17

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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