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Cat. No.: HY-143744

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Suraxavir marboxil

(Synonyms: GP681; Cap-dependent endonuclease-IN-3)

Suraxavir marboxil (GP681; Cap-dependent endonuclease-IN-3) is a PA subunit cap-dependent endonuclease inhibitor with antiviral activity. Suraxavir marboxil inhibits PA subunit cap-dependent endonuclease activity and inhibits influenza A and/or influenza B viral replication. Suraxavir marboxil can be used alone or in combination with other anti-influenzal agents for the prevention of influenza A and/or influenza B viral infectious diseases. Suraxavir marboxil can be used for the research of influenza A and/or influenza B viral infectious diseases.

For research use only. We do not sell to patients.

CAS No.: 2364589-86-4
Formula: C₂₉H₂₅F₂N₃O₇S
Molecular Weight:597.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Suraxavir marboxil Chemical Structure

CAS No.: 2364589-86-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Parmacokinetics
- In Vivo
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	F
Rat^[1]	3.0 mg/kg	i.g.	3.32 h	1.67 h	253 ng/mL	1377 ng·h/mL	47.2 %

In Vivo

Suraxavir marboxil (Compound III-2) (15 mg/kg; p.o.; daily for 5 days) achieves a statistically significant reduction in lung influenza virus titers in BALB/c mice infected with A/WS/33 (H1N1) virus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice infected with A/WS/33 (H1N1) virus^[1]
Dosage:

15 mg/kg
Administration:

P.o.; daily for 5 days
Result:

Achieved a statistically significant reduction in lung influenza virus titers.
Increased survival rate to 100%.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 2364589-86-4
Molecular Weight 597.59
Formula C₂₉H₂₅F₂N₃O₇S
SMILES

O=C1N2[C@](COC3(CC3)C2)([H])N([C@@]4([H])C5=CC=C(F)C(F)=C5CSC6=CC=CC=C64)N7C1=C(C(C=C7)=O)OCOC(OC)=O
Synonyms

GP681; Cap-dependent endonuclease-IN-3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Chen, et al. Pyridone derivative, composition thereof and application thereof as anti-influenza drug. WO2019141179A1. 2020-07-17

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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