2'-Deoxyguanosine 5'-monophosphate disodium hydrate  (Synonyms: 5'-Deoxyguanylic acid disodium hydrate)

2'-Deoxyguanosine 5'-monophosphate (5'-Deoxyguanylic acid; dGMP) disodium hydrate is an oxidizable target of the photosensitizer pterin (PT) and can be used to evaluate the photosensitizing properties of biopterins (such as Bip, Fop and Cap) . Pterin causes a photosensitive reaction of dGMP under UV-A radiation, causing damage to DNA molecules. There are two main mechanisms for the photosensitive oxidation of purine nucleotides by pterin in vitro: one is the hydrogen abstraction reaction of electron transfer from dGMP to the triplet excited state of pterin (type I mechanism), and the other is the interaction between dGMP and pterin. The reaction produces singlet molecular oxygen (1O2) (Type II mechanism)^[1][2].

C₁₀H₁₄N₅O_7.H₂O_.2Na

146877-98-7

Solid

White to off-white

O[C@H]1C[C@H](N2C=NC3=C2NC(N)=NC3=O)O[C@@H]1COP(O[Na])(O[Na])=O.[x].O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Petroselli G, Dántola M L, Cabrerizo F M, et al. Oxidation of 2 ‘-Deoxyguanosine 5 ‘-Monophosphate Photoinduced by Pterin: Type I versus Type II Mechanism[J]. Journal of the American Chemical Society, 2008, 130(10): 3001-3011.

  [2]. Song B, Sigel H. Metal Ion-Coordinating Properties of 2 ‘-Deoxyguanosine 5 ‘-Monophosphate (dGMP2-) 1 in Aqueous Solution. Quantification of Macrochelate Formation[J]. Inorganic Chemistry, 1998, 37(8): 2066-2069.