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Results for "

beta-lactamases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (5) Antibiotic (146) Apoptosis (13) Autophagy (6) Bacterial (253) Bcl-2 Family (1) Beta-lactamase (209) Biochemical Assay Reagents (2) Cholinesterase (ChE) (1) Complement System (1) Drug Derivative (3) Drug Intermediate (4) Drug Metabolite (1) Endogenous Metabolite (4) Endothelin Receptor (1) Environmental Pollutants (2) Fluorescent Dye (1) Fungal (6) GABA Receptor (8) GCGR (2) GLP Receptor (2) HDAC (16) HIV (1) iGluR (2) Integrin (1) Interleukin Related (5) Isotope-Labeled Compounds (23) Melanocortin Receptor (9) Neurokinin Receptor (1) PACAP Receptor (3) Parasite (2) Penicillin-binding protein (PBP) (12) Phosphodiesterase (PDE) (1) Phospholipase (1) PKC (1) Prostaglandin Receptor (2) Reference Standards (50) TNF Receptor (1) Toll-like Receptor (TLR) (2) Virus Protease (3)
By Research Areas:	Cancer (43) Cardiovascular Disease (11) Endocrinology (2) Infection (283) Inflammation/Immunology (29) Metabolic Disease (12) Neurological Disease (10)

By Targets:

Angiotensin-converting Enzyme (ACE) (5)

Antibiotic (146)

Apoptosis (13)

Autophagy (6)

Bacterial (253)

Bcl-2 Family (1)

Beta-lactamase (209)

Biochemical Assay Reagents (2)

Cholinesterase (ChE) (1)

Complement System (1)

Drug Derivative (3)

Drug Intermediate (4)

Drug Metabolite (1)

Endogenous Metabolite (4)

Endothelin Receptor (1)

Environmental Pollutants (2)

Fluorescent Dye (1)

Fungal (6)

GABA Receptor (8)

GCGR (2)

GLP Receptor (2)

HDAC (16)

HIV (1)

iGluR (2)

Integrin (1)

Interleukin Related (5)

Isotope-Labeled Compounds (23)

Melanocortin Receptor (9)

Neurokinin Receptor (1)

PACAP Receptor (3)

Parasite (2)

Penicillin-binding protein (PBP) (12)

Phosphodiesterase (PDE) (1)

Phospholipase (1)

PKC (1)

Prostaglandin Receptor (2)

Reference Standards (50)

TNF Receptor (1)

Toll-like Receptor (TLR) (2)

Virus Protease (3)

By Research Areas:

Cancer (43)

Cardiovascular Disease (11)

Endocrinology (2)

Infection (283)

Inflammation/Immunology (29)

Metabolic Disease (12)

Neurological Disease (10)

346

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14879A

Avibactam sodium Maximum Cited Publications 92 Publications Verification NXL-104	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-16752

Relebactam 25+ Cited Publications MK-7655	Beta-lactamase Bacterial	Infection
Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of *β-lactamases, including class A (extended-spectrum β-lactamases* and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity .

HY-B0593

Ceftazidime 40+ Cited Publications GR20263	Beta-lactamase Bacterial Antibiotic	Infection Cancer
Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .

HY-A0090

Nitrofurantoin 5+ Cited Publications	Bacterial Antibiotic	Infection
Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .

HY-108913

Nitrocefin 2 Publications Verification	Beta-lactamase Antibiotic Bacterial	Infection
Nitrocefin is a highly activated, chromogenic cephalosporin derivative. Nitrocefin is a chromogenic *β-lactamase* substrate. Nitrocefin undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics .

HY-19930

Vaborbactam 40+ Cited Publications RPX7009	Beta-lactamase Bacterial	Infection
Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore *β-lactamase* inhibitor.

HY-136072

Xeruborbactam disodium 5+ Cited Publications	Bacterial	Infection
Xeruborbactam disodium is a potent, ultra-broad-spectrum boronic acid *beta-lactamase* inhibitor. Xeruborbactam disodium inhibits key serine and metallo beta-lactamases at a nano molar range .

HY-A0256A

Clavulanate potassium 5+ Cited Publications	Beta-lactamase Bacterial Antibiotic	Infection
Clavulanate potassium is a potent *β-lactamase* inhibitor and acts as an antibiotic .

HY-B0334

Sulbactam 10+ Cited Publications CP45899	Bacterial Antibiotic	Infection
Sulbactam (CP45899) is a competitive, irreversible *beta-lactamase* inhibitor. Sulbactam shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .

HY-B0593A

Ceftazidime pentahydrate 40+ Cited Publications GR20263 pentahydrate	Beta-lactamase Bacterial Antibiotic	Infection Cancer
Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .

HY-A0256B

Clavulanate lithium 5+ Cited Publications	Beta-lactamase Bacterial Antibiotic	Infection
Clavulanate lithium is a potent *β-lactamase* inhibitor and acts as an antibiotic .

HY-111521

Meropenem-vaborbactam Carbavance	Antibiotic Bacterial Beta-lactamase	Infection
Meropenem-vaborbactam (Carbavance) is a Carbapenem Antibiotic and Boronic acid-based *beta-lactamase* inhibitor, is a fixed-dose combination product with potent in vitro activity against Enterobacteriaceae that are Klebsiella pneumoniae carbapenemase producers. Meropenem-vaborbactam exhibits activity against Pseudomonas aeruginosa isolates , with an MIC₅₀ of 0.5 μg/mL and an MIC₉₀ of 8 μg/mL .

HY-W009168

Tazobactam sodium 15+ Cited Publications	Bacterial Antibiotic	Infection Cancer
Tazobactam sodium is an antibiotic of the beta-lactamase inhibitor class. Ceftolozane combines with Tazobactam, extends the activity of ceftolozane against many ESBL-producing Enterobacteriaceae and some Bacteroides spp..

HY-B0334A

Sulbactam sodium 10+ Cited Publications CP45899 sodium	Bacterial Antibiotic	Infection
Sulbactam (CP45899) sodium is a competitive, irreversible *beta-lactamase* inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .

HY-14879

Avibactam free acid Maximum Cited Publications 92 Publications Verification NXL-104 free acid	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-147274

Funobactam XNW4107	Beta-lactamase Bacterial	Infection
Funobactam (XNW4107) is a *β-lactamase* inhibitor, can be used for researching anti-bacteria .

HY-14879AR

Avibactam sodium (Standard) NXL-104 (Standard)	Beta-lactamase Reference Standards Bacterial Antibiotic	Infection
Avibactam (sodium) (Standard) is the analytical standard of Avibactam (sodium). This product is intended for research and analytical applications. Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-136069

Xeruborbactam	Bacterial	Infection
Xeruborbactam is a potent, ultra-broad-spectrum boronic acid *beta-lactamase* inhibitor. Xeruborbactam inhibits key serine and metallo beta-lactamases at a nano molar range .

HY-W654023

Tazobactam-15N3 sodium	Isotope-Labeled Compounds	Others
Tazobactam- ¹⁵N₃ sodium is the ¹⁵N labeled isotope of Tazobactam sodium (HY-W009168) . Tazobactam sodium is an antibiotic of the beta-lactamase inhibitor class.

HY-142128

Cymal-6 Cyclohexyl-hexyl-β-D-maltoside	Bacterial	Infection
Cymal-6 (Cyclohexyl-hexyl-β-D-maltoside) is a potent TEM-1 beta-lactamase inhibitor with an K_i value of 40.05 µM. Cymal-6 (Cyclohexyl-hexyl-β-D-maltoside) can be used as glycosidic surfactant .

HY-14879B

Avibactam sodium hydrate Maximum Cited Publications 92 Publications Verification NXL-104 hydrate	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-B0593R

Ceftazidime (Standard) GR20263 (Standard)	Beta-lactamase Reference Standards Bacterial Antibiotic	Infection
Ceftazidime (Standard) is the analytical standard of Ceftazidime. This product is intended for research and analytical applications. Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .

HY-N7111

Sultamicillin tosylate Sultamicillin (tosilate)	Bacterial Antibiotic	Infection
Sultamicillin tosylate is a broad-spectrum and orally active *beta-lactamase* inhibitor, an antibiotic with antibacterial activity .

HY-N7115

Sultamicillin	Bacterial Antibiotic	Infection
Sultamicillin is a broad-spectrum and orally active *beta-lactamase* inhibitor, an antibiotic with antibacterial activity .

HY-148790

Pralurbactam FL058	Bacterial Beta-lactamase	Infection
Pralurbactam (FL058) is a β-lactamase (Beta-lactamase) inhibitor. Pralurbactam enhances the antibacterial activity of Imipenem against Mycobacterium abscessus. Pralurbactam reduces the pulmonary bacterial load in neutropenic mice infected with Mycobacterium abscessus. Pralurbactam can be used in research related to infections caused by Mycobacterium abscessus complex, Escherichia coli, and Klebsiella pneumoniae .

HY-A0090R

Nitrofurantoin (Standard)	Reference Standards Bacterial Antibiotic	Infection
Nitrofurantoin (Standard) is the analytical standard of Nitrofurantoin. This product is intended for research and analytical applications. Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .

HY-108062A

BLI-489 hydrate	Beta-lactamase Bacterial	Infection
BLI-489 hydrate, a penem *β-lactamase* inhibitor, is active against class A and class C as well as some class D β-lactamases. The combination of Piperacillin and BLI-489 hydrate is efficacious against murine infections caused by class A (including extended-spectrum β-lactamases), class C (AmpC), and class D β-lactamase-expressing pathogens .

HY-136306

*Metallo β-lactamase* ligand 1**	Beta-lactamase Bacterial	Infection
Metallo-beta-lactamase ligand 1 is a class B *β-lactamase* inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A .

HY-121694

CENTA	Beta-lactamase	Infection
CENTA is a colorimetric cephalosporin substrate for β-lactamases. Upon hydrolysis by β-lacatamases, CENTA turns from light yellow to chrome yellow, which can be quantified by colorimetric detection at 405 nm as a measure of β-lactamase activity.

HY-16752R

Relebactam (Standard) MK-7655 (Standard)	Beta-lactamase Reference Standards Bacterial	Infection
Relebactam (Standard) is the analytical standard of Relebactam. This product is intended for research and analytical applications. Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of *β-lactamases, including class A (extended-spectrum β-lactamases* and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity .

HY-19050

BRL-42715	Beta-lactamase Bacterial	Infection
BRL-42715 is a potent inhibitor of a broad range of bacterial beta-lactamases (β-lactamase) .

HY-125604

WCK-4234	Beta-lactamase Bacterial	Infection Inflammation/Immunology
WCK-4234 is a diazabicyclooctane β-lactamase inhibitor and susceptibility restorer. WCK-4234 lacks direct antibacterial activity. WCK-4234 inhibits class A, C, D β-lactamases and extended-spectrum β-lactamases to potentiate Imipenem (HY-B1369A) and Meropenem (HY-13678) activity against Gram-negative pathogens. WCK-4234 can be used for the research of gram-negative bacterial infections and β-lactamase-mediated carbapenem-resistant bacterial infections .

HY-119945A

Brobactam sodium	Bacterial Beta-lactamase	Infection
Brobactam sodium is a potent synthetic wide spectrum *β-lactamase* inhibitor. Brobactam sodium has antibacterial activity .

HY-A0035

Faropenem	Antibiotic Bacterial	Infection
Faropenem is a potent and orally active beta-lactam antibiotic. Faropenem demonstrates broad-spectrum in vitro antimicrobial activity against many gram-positive and -negative aerobes and anaerobes. Faropenem is resistant to hydrolysis by nearly all beta-lactamases, including extended-spectrum beta-lactamases and AmpC beta-lactamases. Faropenem is developed as an oral proagent, faropenem medoxomil, for the research of respiratory tract infections .

HY-B0334AS

Sulbactam-d5 sodium	Bacterial Antibiotic	Infection
Sulbactam-d₅ (sodium) is the deuterium labeled Sulbactam sodium. Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .

HY-B0334AR

Sulbactam sodium (Standard) CP45899 sodium (Standard)	Reference Standards Bacterial Antibiotic	Infection
Sulbactam (sodium) (Standard) is the analytical standard of Sulbactam (sodium). This product is intended for research and analytical applications. Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .

HY-A0090S

Nitrofurantoin-13C3	Isotope-Labeled Compounds Antibiotic Bacterial	Others
Nitrofurantoin- ¹³C₃ is the ¹³C labeled Nitrofurantoin (HY-A0090) . Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .

HY-144659

*Metallo-β-lactamase-IN-5*	Beta-lactamase Apoptosis Bacterial	Infection
Metallo-β-lactamase-IN-5 (compound 5c) is a potent *metallo-β-lactamases* (MBL)** inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC₅₀ of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity .

HY-19773

β-Lactamase-IN-1	Beta-lactamase Bacterial	Infection
β-Lactamase-IN-1 is an inhibitor of *β-Lactamase* extracted from patent WO2016027249A1, page 77. β-Lactamase-IN-1 can be used to prepare of tricyclic nitrogen containing compound. β-Lactamase-IN-1 can be used for the research of neisseria gonorrhea infection .

HY-146637

VIM-2-IN-1	Beta-lactamase Bacterial	Infection
VIM-2-IN-1 (compound 1dj) is a *β-lactamase* inhibitor with antibacterial activities. VIM-2-IN-1 has moderate IC₅₀ values of 23 µM, 48 µM and 231 µM for *Verona integron-encoded metallo-β-lactamase* (VIM-2), German imipenemase-1 (GIM-1) and New Delhi metallo-β-lactamase (NDM-1)**, respectively .

HY-138247

β-Lactamase-IN-2 EX-A4764; UUN51204	Beta-lactamase Bacterial Antibiotic	Infection
β-Lactamase-IN-2 is a *beta-lactamase* inhibitor, extracted from patent WO 2019075084 A1, compound 1. β-Lactamase-IN-2 has anti-microbial and anti-bacterial effects .

HY-108062

BLI-489	Beta-lactamase Bacterial	Infection
BLI-489 is a *beta-lactamase* inhibitor. BLI-489 combined with Piperacillin (HY-B1923) inhibits infection caused by class A (including ultra-broad spectrum β-lactamase), Class C (AmpC) and Class D β-lactamase expressing pathogens .

HY-B0334AS1

Sulbactam-d2 sodium CP45899-d2 sodium	Bacterial Antibiotic	Infection
Sulbactam-d₂ (sodium) is the deuterium labeled Sulbactam sodium . Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .

HY-B0334S

Sulbactam-d3 CP45899-d₃	Isotope-Labeled Compounds Antibiotic Bacterial	Infection
Sulbactam-d₃ (CP45899-d₃) is deuterium labeled Sulbactam. Sulbactam (CP45899) is a competitive, irreversible *beta-lactamase* inhibitor. Sulbactam shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .

HY-163338

*Metallo-β-lactamase-IN-13*	Beta-lactamase	Infection
Metallo-β-lactamase-IN-13 (Compound 13i) is a pan *Metallo-β-Lactamase* inhibitor. Metallo-β-lactamase-IN-13 provides broader coverage of metallo-β-lactamases expressing Gram-negative (GN) bacteria. Metallo-β-lactamase-IN-13 has antibacterial activity against P. aeruginosa .

HY-P2998

*β-Lactamase*	Beta-lactamase Biochemical Assay Reagents	Infection
β-Lactamase is the enzyme produced by bacteria. β-Lactamase mediates β-lactam resistance .

HY-108913R

Nitrocefin (Standard)	Beta-lactamase Reference Standards Antibiotic	Infection
Nitrocefin (Standard) is the analytical standard of Nitrocefin. This product is intended for research and analytical applications. Nitrocefin is a chromogenic β-lactamase substrate that undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics .

HY-14879E

rel-Avibactam sodium NXL-104 sodium	Beta-lactamase Bacterial	Infection
Ent-Avibactam (NXL-104) sodium is a *β-lactamase* inhibitor with broad-spectrum antibacterial activity. When combined with Cefazidime (HY-B0593), rel-Avibactam sodium exhibits significant inhibitory effects on Enterobacteriaceae bacteria that produce Ambler A and C types of β-lactamases. The IC₅₀ value of rel-Avibactam sodium is much lower than that of commonly used β-lactamase inhibitors Clavulanic acid (HY-A0256) and Ticarcillin (HY-139805), demonstrating its high efficiency in inhibiting TEM-1 and P99 enzymes .

HY-121195

Apalcillin PC-904	Bacterial	Infection
Apalcillin (PC-904) in combination with Ro 48-1220, a penam sulfone β-lactamase inhibitor, demonstrated broad-spectrum activity against gram-negative aerobic and anaerobic bacteria, excluding Klebsiella oxytoca. It exhibited potent activity against β-lactamase-producing Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae, with effective MICs (11 μg/mL). The combination also inhibited Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter species at low MICs (0.25 to 4 μg/mL). However, its efficacy against oxacillin-resistant staphylococci and certain gram-positive organisms was limited. Apalcillin/Ro 48-1220 showed comparable efficacy to piperacillin/tazobactam against some extended-spectrum β-lactamase-producing Escherichia coli but was less effective against SHV-type β-lactamases .

HY-14879BR

Avibactam sodium hydrate (Standard) NXL-104 hydrate (Standard)	Beta-lactamase Reference Standards Bacterial Antibiotic	Infection
Avibactam (sodium hydrate) (Standard) is the analytical standard of Avibactam (sodium hydrate). This product is intended for research and analytical applications. Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].

Cat. No.	Product Name	Type

HY-129042

Cibacron Blue 3G-A 1 Publications Verification	Fluorescent Dyes
Cibacron Blue 3G-A is an anthraquinone dye, inhibits the R46 *β-lactamase* with a K_i value of 1.2 uM .

HY-121694

CENTA	Fluorescent Dyes
CENTA is a colorimetric cephalosporin substrate for β-lactamases. Upon hydrolysis by β-lacatamases, CENTA turns from light yellow to chrome yellow, which can be quantified by colorimetric detection at 405 nm as a measure of β-lactamase activity.

HY-13271AG

Tubastatin A

Fluorescent Dyes

Tubastatin A (GMP) is the Tubastatin A (HY-13271A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tubastatin A is a potent and selective HDAC6 inhibitor with an IC₅₀ of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).

Cat. No.	Product Name	Type

HY-13271AG

Tubastatin A

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P0267

Melanotan (MT)-II 1 Publications Verification	Melanocortin Receptor	Neurological Disease
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning.

HY-106178

PMX-53 Maximum Cited Publications 8 Publications Verification 3D53	Complement System	Cardiovascular Disease Inflammation/Immunology Cancer
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects .

HY-18678A

Bremelanotide Acetate 1 Publications Verification PT-141 Acetate	Melanocortin Receptor	Metabolic Disease
Bremelanotide (PT-141) Acetate is a melanocortin receptor agonist. Bremelanotide Acetate can activate MC4R and increases dopamine release. Bremelanotide Acetate induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide Acetate can be used for the research of hypoactive sexual desire disorders .

HY-P0227

SHU 9119 3 Publications Verification	Melanocortin Receptor	Metabolic Disease
SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC₅₀ values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.

HY-145632

Pemvidutide ALT-801	GLP Receptor GCGR	Metabolic Disease
Pemvidutide (ALT-801) is a GLP-1R/GCGR dual agonist, shows striking reductions in body weight, liver fat and serum lipids. Pemvidutide can be used in non-alcoholic steatohepatitis (NASH) and obesity research .

HY-A0248A

Polymyxin B1 1 Publications Verification	Bacterial	Infection
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-P5189A

*His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA*	Endogenous Metabolite Cholinesterase (ChE)	Others
His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA, is a growth hormone releasing peptide, as well as a metabolite of GHRP-1. GHRP-1, or Ala-His-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2, has the effect of promoting the release of growth hormone (GH). GHRP-1 increases GH release and increases [Ca2+]i levels in static monolayer cells of rat pituitary gland, but does not affect cAMP levels .

HY-P11290

MC4-NN2-0453	Melanocortin Receptor	Metabolic Disease
MC4-NN2-0453, a α-MSH analog, is a selective MC4R agonist. MC4-NN2-0453 can be used for obesity research .

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase Fungal	Infection
Plipastatin A1 (Fengycin IX; SNA-60-367-3) is a lipopeptide with phospholipase A2 inhibitory activity. Plipastatin A1 inhibits conidial germination of Botrytis cinerea in vitro and reduces the incidence of gray mold on tomato leaves. Plipastatin A1 is applicable to research related to gray mold ^[1][2].

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-A0248AS

Polymyxin B1-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-145632A

Pemvidutide TFA ALT-801 TFA	GLP Receptor GCGR	Metabolic Disease
Pemvidutide (ALT-801) TFA is a GLP-1R/GCGR dual agonist, shows striking reductions in body weight, liver fat and serum lipids. Pemvidutide TFA can be used in non-alcoholic steatohepatitis (NASH) and obesity research .

HY-P1195

PDZ1 Domain inhibitor peptide	iGluR	Neurological Disease
PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain .

HY-P10278

Anantin	Peptides	Endocrinology
Anantin binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (K_d = 0.6 μM) and acts as natriuretic peptide receptor A antagonist .

HY-P10768A

Ro 25-1553 TFA	PACAP Receptor	Inflammation/Immunology
Ro 25-1553 TFA is a 31 amino acid vasoactive intestinal peptide (VIP) analog, that acts as an agonist for VIP2 receptor (VPAC2 receptor). Ro 25-1553 TFA exhibits a bronchodilator effect in nerve-induced or Carbachol (HY-B1208)-induced tracheal smooth muscle contraction in guinea pig model .

HY-P3100

Orfamide A	Parasite	Infection
Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC₅₀ value of 34.5 μg/mL .

HY-P1209A

PG106 TFA	Melanocortin Receptor	Metabolic Disease
PG106 TFA is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC₅₀= 210 nM) and has noactivity at hMC4 receptors (EC₅₀=9900 nM) and hMC5 receptor .

HY-P2064

Lariatin A	Bacterial	Infection
Lariatins is a novel anti-mycobacterial peptides with a lasso structure produced by Rhodococcus jostii K01-B0171 .

HY-P0007

Elcatonin Carbocalcitonin	Drug Intermediate	Metabolic Disease
Elcatonin (Carbocalcitonin) is a synthetic analog of eel calcitonin. Elcatonin increases bone mineral density, inhibits bone resorption and processes a central analgesic effect .

HY-P10768

Ro 25-1553	PACAP Receptor	Inflammation/Immunology
Ro 25-1553 is a selective VIP₂ receptor (VPAC₂ receptor) agonist. Ro 25-1553 exhibits bronchodilatory effects on tracheal smooth muscle contractions induced by nerve stimulation or Carbachol (HY-B1208). Ro 25-1553 produces a superimposed effect when combined with Formoterol and Salmeterol (HY-14302). Ro 25-1553 can be used for the study of bronchoconstriction .

HY-P1193

GR 82334	Neurokinin Receptor	Neurological Disease
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist . GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats .

HY-P2123A

Colistin A sulfate hydrate	Bacterial Antibiotic	Infection
Colistin A sulfate hydrate is a major component of Colistin. Colistin is a polymyxin antibiotic and can be used to combat infections caused by problematic gram-negative bacteria .

HY-P1209

PG106	Melanocortin Receptor	Inflammation/Immunology
PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC₅₀=210 nM) and has noactivity at hMC4 receptors (EC₅₀=9900 nM) and hMC5 receptor .

HY-P2120

Pseudobactin A	Bacterial	Others
Pseudobactin A is a non-fluorescent extracellular iron carrier produced by the plant growth-promoting bacterium Pseudomonas B10 .

HY-P1195A

PDZ1 Domain inhibitor peptide TFA	iGluR	Neurological Disease
PDZ1 Domain inhibitor peptide TFA, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide TFA disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain .

HY-P10135

RES-701-1	Endothelin Receptor	Cardiovascular Disease
RES-701-1 is a cyclic peptide composed of 16 common L-amino acids, acting as a specific antagonist for the ET_B receptor. RES-701-1 can inhibit the binding of 125I-ET-1 (125I-labeled Endothelin (ET)-1) to the ET_B receptor, with an IC₅₀ value of 10 nM .

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P5568

Siamycin III RP 71955	HIV	Infection
RP 71955 is an antimicrobial peptide against HIV-1 .

HY-P2202

Desferriferribactin	Bacterial	Others
Desferriferribactin is a cyclic peptide containing a thirteen-membered ring. Desferriferribactin is a precursor of pyoverdins .

HY-P11232

NAB815	Toll-like Receptor (TLR) Bacterial	Infection
NAB815 is a specific inhibitor of the Stx2a (K_d = 0.01 μM)/TLR4 interaction. NAB815 inhibits the neutrophil/Stx2a interaction (IC₅₀ = 0.057 μg/mL). NAB815 inhibits the formation of Stx2-containing extracellular vesicles (EVs) produced by leukocytes and platelets and reduces their toxic effects in cellular (Vero cells) and animal models (CD-1 mice). NAB815 reduces bacterial loads in the kidneys, urine, and bladders of Escherichia coli-infected mice. NAB815 is useful in the study of hemolytic uremic syndrome (HUS) .

HY-P10768B

Ro 25-1553 acetate	PACAP Receptor	Inflammation/Immunology
Ro 25-1553 acetate is a selective VIP₂ receptor (VPAC₂ receptor) agonist. Ro 25-1553 acetate exhibits bronchodilatory effects on tracheal smooth muscle contractions induced by nerve stimulation or Carbachol (HY-B1208). Ro 25-1553 acetate produces a superimposed effect when combined with Formoterol and Salmeterol (HY-14302). Ro 25-1553 acetate can be used for the study of bronchoconstriction .

HY-P0267A

Melanotan (MT)-II acetate	Melanocortin Receptor	Neurological Disease Metabolic Disease Endocrinology
Melanotan (MT)-II acetate is a melanocortin receptor agonist that crosses the blood-brain barrier. Melanotan (MT)-II acetate activates melanocortin receptor 3 and melanocortin receptor 4, and stimulates the release of central endogenous oxytocin. Melanotan (MT)-II acetate reverses recognition memory impairment, increased anxiety levels and reduced exploratory tendency in zebrafish exposed to short-term high-fat diet. Melanotan (MT)-II acetate improves impaired social behavior indicators in mouse models of autism spectrum disorder. Melanotan (MT)-II acetate induces weight loss, reduces food intake and exerts anorectic effects. Melanotan (MT)-II acetate increases intracavernous pressure and erectile activity in brown rats. Melanotan (MT)-II acetate can be used in studies related to memory impairment, anxiety, reduced exploratory behavior, autism spectrum disorder, obesity and erectile dysfunction .

HY-P2123S

Colistin A-d7 TFA

HY-P11596

NOTA-Asp2-αvβ6L	Integrin	Cancer
NOTA-Asp2-αvβ6L is an integrin αvβ6 binder with selective accumulation in αvβ6-positive pancreatic cancer cells and tumors. NOTA-Asp2-αvβ6L can be used as a PET/CT tracer for imaging pancreatic ductal adenocarcinoma (PDAC) .

HY-P11676

Soralimixin BRII-693; QPX9003	Antibiotic Bacterial	Infection
Soralimixin (BRII-693), a Polymyxin derivative, is a next-generation intravenous (IV)-administered synthetic macrocyclic peptide antibiotic. Soralimixin can be used for the study of infections caused by drug-resistant Gram-negative pathogens .

HY-P11607

CyLip-10	Bacterial	Infection
CyLip-10 is a microbial-derived cyclic-lipid antimicrobial peptide. CyLip-10 has broad-spectrum antimicrobial efficacy, low hemolytic activity, and excellent stability. CyLip-10 can disrupt membrane integrity, inhibit biofilm formation and induce membrane permeabilization and bacterial cell death. CyLip-10 reduces bacterial load, promotes wound healing, and alleviates inflammatory responses in a mouse Methicillin (HY-121544)-resistant Staphylococcus aureus skin wound infection model. CyLip-10 can be used for the bacterial infection .

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Parasite Phosphodiesterase (PDE)	Infection
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca ²⁺-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1418

Tazobactam Maximum Cited Publications 18 Publications Verification CL-298741; YTR-830H	Infection Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Beta-lactam Antibiotics Source Classification	Beta-lactamase Antibiotic Bacterial
Tazobactam (CL-298741) is a potent *β-lactamases* inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research .

HY-N2598

Methyl oleate	Structural Classification Natural Products Classification of Application Fields Taxaceae Other Diseases Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Source Classification	Environmental Pollutants Bacterial
Methyl oleate is a fatty acid methyl ester (FAME) with anti-extended spectrum β-Lactamase (ESBL) potential, anticancer and antibacterial activities. Methyl oleate substantially improves the antioxidation ability but markedly impaired the antiwear capacity of zinc dialkyldithiophosphate (ZDDP). Methyl oleate is promising for research of ESBL producing multi drug resistant (MDR) pathogens .

HY-A0248A

Polymyxin B1 1 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-B1434

7-Aminocephalosporanic acid 2 Publications Verification 7-ACA	Infection Classification of Application Fields Disease Research Fields	Beta-lactamase Bacterial Antibiotic
7-aminocephalosporanic acid (7-ACA) is a *HSP90β* inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor .

HY-121765

Dacisteine N,S-Diacetyl-L-cysteine	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less *New Delhi metallo-beta-lactamase-1 (NDM-1)* inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

HY-N7111

Sultamicillin tosylate Sultamicillin (tosilate)	Infection Classification of Application Fields Disease Research Fields	Bacterial Antibiotic
Sultamicillin tosylate is a broad-spectrum and orally active *beta-lactamase* inhibitor, an antibiotic with antibacterial activity .

HY-A0248AS

Polymyxin B1-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-B1418R

Tazobactam (Standard) CL-298741 (Standard); YTR-830H (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Antibiotics Resistance Selection Antibacterial Disease Research Beta-lactam Antibiotics Source Classification	Beta-lactamase Reference Standards Antibiotic Bacterial
Tazobactam (Standard) is the analytical standard of Tazobactam. This product is intended for research and analytical applications. Tazobactam (CL-298741) is a potent *β-lactamases* inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research .

HY-N6736

K-252c	Infection Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Indole Alkaloids Source Classification	Beta-lactamase PKC Bacterial Apoptosis
K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC₅₀ of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase .

HY-105751

Kalafungin Kalamycin; U-19718	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial Beta-lactamase Fungal
Kalafungin is an antibiotic, antimicrobial agent and a *β-lactamase* inhibitor from marine Streptomyces, with IC₅₀ of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria .

HY-N15020

Izumenolide	Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Beta-lactamase
Izumenolide is found in the strain of Micromonospora chalcea subsp. izumensis. Izumenolide inhibited some β-lactamases, and the IC₅₀ concentration of TEM-2 β-lactamase was 0.01 μg/mL .

HY-N13977

Carpetimycin A	Structural Classification Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Beta-lactamase Bacterial
Carpetimycin A has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin A has a strong inhibitory effect on *β-lactamase* .

HY-N13980

Carpetimycin D	Structural Classification Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Beta-lactamase Bacterial
Carpetimycin D has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin D has a strong inhibitory effect on *β-lactamase* .

HY-N13978

Carpetimycin B	Structural Classification Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Beta-lactamase Bacterial
Carpetimycin B has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin B has a strong inhibitory effect on *β-lactamase* .

HY-N13979

Carpetimycin C	Structural Classification Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Beta-lactamase Bacterial
Carpetimycin C has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin C has a strong inhibitory effect on *β-lactamase* .

HY-N14182

Asparenomycin A	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Asparenomycin A is a carbapenem antibiotic with strong β-lactamase inhibition activities .

HY-N14185

Asparenomycin C	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Asparenomycin C is a carbapenem antibiotic with strong β-lactamase inhibition activities .

HY-N14183

Asparenomycin B	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Asparenomycin B is a carbapenem antibiotic with strong β-lactamase inhibition activities .

HY-N14919

Olivanic acid	Structural Classification Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Beta-lactamase Antibiotic Bacterial
Olivanic acid is a β -lactam antibiotic. Olivanic acid has the effect of anti -Gram-positive bacteria and anti-Gram-negative bacteria. Olivanic acid inhibits β-lactamase .

HY-N14693

Pluracidomycin B	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Pluracidomycin B is a carbapenem antibiotic. Pluracidomycin B has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .

HY-N14694

Pluracidomycin C1	Structural Classification Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Antibiotic Bacterial
Pluracidomycin C1 is a carbapenem antibiotic. Pluracidomycin C1 has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .

HY-N14692

Pluracidomycin A1	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Pluracidomycin A1 is a carbapenem antibiotic . Pluracidomycin A1 has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .

HY-N13994

Clavamycin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal
Clavamycin A has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase .

HY-N13997

Clavamycin C	Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal
Clavamycin C has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase .

HY-N13999

Clavamycin D	Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal
Clavamycin D has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase .

HY-121765R

Dacisteine (Standard) N,S-Diacetyl-L-cysteine (Standard)	Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Dacisteine (Standard) is the analytical standard of Dacisteine. This product is intended for research and analytical applications. Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less *New Delhi metallo-beta-lactamase-1 (NDM-1)* inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

HY-W015786R

4-Ethoxyphenol (Standard)	Structural Classification Monophenols Phenols Endogenous metabolite Source Classification	Reference Standards Bacterial
L-Amoxicillin (Standard) is the analytical standard of L-Amoxicillin. This product is intended for research and analytical applications. L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application .

HY-129200

Aspergillomarasmine A	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite
Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators .

HY-N13996

Clavamycin B	Microorganisms Antibiotics Other Antibiotics Beta-lactam Antibiotics Source Classification	Fungal
Clavamycin B has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase .

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Structural Classification Alkaloids Other Alkaloids Plants Actaea simplex (DC.) Wormsk. ex Fisch. & C. A. Mey. Rhamnaceae Source Classification	Parasite Phosphodiesterase (PDE)
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca ²⁺-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	Product Name	Chemical Structure

HY-B1923S

Piperacillin-d5
Piperacillin-d₅ is deuterium labeled Piperacillin. Piperacillin is kind of semisynthetic penicillins. Piperacillin has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Piperacillin has shown greater activity against β-lactamase-producing organisms than the other penicillins .

HY-W654023

Tazobactam-15N3 sodium
Tazobactam- ¹⁵N₃ sodium is the ¹⁵N labeled isotope of Tazobactam sodium (HY-W009168) . Tazobactam sodium is an antibiotic of the beta-lactamase inhibitor class.

HY-14879S2

Avibactam sodium salt-13C5
Avibactam sodium salt- ¹³C₅ (NXL-104- ¹³C₅) is ¹³C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-143831S

Cefepime-d8 sulfate

Cefepime-d₈ (BMY-28142-d₈) sulfate is deuterium labeled Cefepime sulfate. Cefepime sulfate is a broad-spectrum, blood-brain barrier-permeable cephalosporin antibiotic with hPON1 inhibitory activity, with an IC₅₀ of 21.115 mM and a K_i of 35.092 mM. Cefepime sulfate inhibits hPON1 via a non-competitive mechanism and blocks GABA_A receptors. Cefepime sulfate penetrates the outer membrane of Gram-negative bacteria, inhibits the growth of Gram-positive and Gram-negative bacteria, and does not induce the production of β-lactamase.

HY-B0593S

Ceftazidime-d5
Ceftazidime-d₅ (GR20263-d₅) is the deuterium labeled Ceftazidime (HY-B0593). Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .

HY-W654100

Cefepime-d3 sulfate

Cefepime-d₃ (BMY-28142-d₃) sulfate is deuterium labeled Cefepime sulfate. Cefepime sulfate is a broad-spectrum, blood-brain barrier-permeable cephalosporin antibiotic with hPON1 inhibitory activity, with an IC₅₀ of 21.115 mM and a K_i of 35.092 mM. Cefepime sulfate inhibits hPON1 via a non-competitive mechanism and blocks GABA_A receptors. Cefepime sulfate penetrates the outer membrane of Gram-negative bacteria, inhibits the growth of Gram-positive and Gram-negative bacteria, and does not induce the production of β-lactamase.

HY-A0248AS

Polymyxin B1-d7 TFA

Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-B0334AS

Sulbactam-d5 sodium
Sulbactam-d₅ (sodium) is the deuterium labeled Sulbactam sodium. Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .

HY-A0090S

Nitrofurantoin-13C3
Nitrofurantoin- ¹³C₃ is the ¹³C labeled Nitrofurantoin (HY-A0090) . Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .

HY-B0555BS

Nafcillin-d5 sodium
Nafcillin-d₅ (sodium) is the deuterium labeled Nafcillin sodium. Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium can be used for the research of staphylococcal infections .

HY-B1256S

Cefuroxime-d3
Cefuroxime-d₃ is deuterium labeled Cefuroxime (sodium). Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria .

HY-W654101

Cefotaxime-d3
Cefotaxime-d3 is the deuterium labeled Cefotaxime (HY-A0088A). Cefotaxime is the β-lactamase stable cephalosporin and the third-generation cephalosporin antibiotic. Cefotaxime possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .

HY-W654157

Dicloxacillin-13C4 sodium hydrate
Dicloxacillin- ¹³C₄ sodium hydrate is the ¹³C-labeled Dicloxacillin Sodium hydrate (HY-B0977). Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to study infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus .

HY-B0334AS1

Sulbactam-d2 sodium
Sulbactam-d₂ (sodium) is the deuterium labeled Sulbactam sodium . Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .

HY-B0334S

Sulbactam-d3
Sulbactam-d₃ (CP45899-d₃) is deuterium labeled Sulbactam. Sulbactam (CP45899) is a competitive, irreversible *beta-lactamase* inhibitor. Sulbactam shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .

HY-A0088S

Cefotaxime-d3 sodium
Cefotaxime-d₃ (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .

HY-B1418S2

Tazobactam-15N,d2
Tazobactam- ¹⁵N,d₂ (CL-298741- ¹⁵N,d₂) is ¹⁵N and deuterium labeled Tazobactam. Tazobactam (CL-298741) is a potent *β-lactamases* inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research .

HY-16752S1

Relebactam-d9
Relebactam-d₉ (MK-7655-d₉) is deuterium labeled Relebactam. Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of *β-lactamases, including class A (extended-spectrum β-lactamases* and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity .

HY-B1459AS

Dicloxacillin-13C4
Dicloxacillin- ¹³C₄ is the ¹³C labeled Dicloxacillin (HY-B1459A) . Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus .

HY-B0368S

Captopril-d3

Captopril-d₃ is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-W740028

Cefditoren-d3 sodium

Cefditoren-d₃ (sodium) (ME 1206-d₃) is deuterium labeled Cefditoren (sodium). Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .

HY-B0368S1

Captopril-13C5,15N

Captopril- ¹³C₅, ¹⁵N (SQ 14225- ¹³C₅, ¹⁵N) is ¹³C and ¹⁵N labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-17452AS

Cefditoren pivoxil-d3

Cefditoren Pivoxil-d₃ (Cefditoren pivoxyl-d₃) is deuterium labeled Cefditoren Pivoxil. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .

HY-W743258

L-Amoxicillin-d4 sodium

L-Amoxicillin-d₄ sodium is the deuterium labeled L-Amoxicillin (HY-129836). L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application .

HY-14879S7

Avibactam-13C5,15N sodium
Avibactam- ¹³C₅,15N sodium (NXL-104- ¹³C₅, ¹⁵N sodium) is the ¹³C- and ¹⁵N-labeled Avibactam (HY-14879). Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-P2123S

Colistin A-d7 TFA

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA

Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13271AG

Tubastatin A	HDAC Beta-lactamase Autophagy Apoptosis	Cancer
Tubastatin A (GMP) is the Tubastatin A (HY-13271A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tubastatin A is a potent and selective HDAC6 inhibitor with an IC₅₀ of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and *metallo-β-lactamase* domain-containing protein 2 (MBLAC2)**.

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beta-lactamases

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