Ro 25-1553
Ro 25-1553 is a selective VIP2 receptor (VPAC2 receptor) agonist. Ro 25-1553 exhibits bronchodilatory effects on tracheal smooth muscle contractions induced by nerve stimulation or Carbachol (HY-B1208). Ro 25-1553 produces a superimposed effect when combined with Formoterol and Salmeterol (HY-14302). Ro 25-1553 can be used for the study of bronchoconstriction.
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- CAS. Nr.: 159427-08-4
- Formel: C160H258N46O46
- Molecular Weight:3562.04
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
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VPAC2 receptor |
In Vitro
Ro 25-1553 (1×10-11 to 1×10-6 mol l-1) potently induces complete, concentration-dependent relaxation of isolated guinea pig tracheal smooth muscle strips pre-contracted with Carbachol (HY-B1208). Its pD2 value is 8.57 when the pre-contraction concentration of Carbachol is 0.1 μmol l-1, and 7.69 when the pre-contraction concentration of Carbachol is 1.0 μmol l-1[1].
Ro 25-1553 (1×10-11 to 1×10-6 mol l-1) exerts an additive effect with Formoterol to relax isolated guinea pig tracheal smooth muscle strips pre-contracted by 0.1 μmol l-1 Carbachol[1].
Ro 25-1553 (1×10-10 to 1×10-4 mol l-1) potently and completely inhibits vagus nerve-induced contractions in isolated guinea pig tracheal preparations; the pD2 value is 8.31 when administered extraluminally and 6.32 when administered intraluminally[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 159427-08-4
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Molecular Weight 3562.04
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Formel C160H258N46O46
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Sequence
Ac-His-Ser-Asp-Ala-Val-Phe-Thr-Glu-Asn-Tyr-Thr-Lys-Leu-Arg-Lys-Gln-{Nle}-Ala-Ala-Lys-Lys-Tyr-Leu-Asn-Asp-Leu-Lys-Lys-Gly-Gly-Thr-NH2 (Lactam bridge:Lys21-Asp25)
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Sequence Shortening
Ac-HSDAVFTENYTKLRKQ-{Nle}-AAKKYLNDLKKGGT-NH2 (Lactam bridge:Lys21-Asp25)
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (260 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Ro 25-1553 Related Classifications
HY-P10768 Related Classifications
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