Ro 25-1553 

Ro 25-1553 is a selective VIP₂ receptor (VPAC₂ receptor) agonist. Ro 25-1553 exhibits bronchodilatory effects on tracheal smooth muscle contractions induced by nerve stimulation or Carbachol (HY-B1208). Ro 25-1553 produces a superimposed effect when combined with Formoterol and Salmeterol (HY-14302). Ro 25-1553 can be used for the study of bronchoconstriction^[1].

Ro 25-1553 (1×10^-11 to 1×10^-6 mol l^-1) potently induces complete, concentration-dependent relaxation of isolated guinea pig tracheal smooth muscle strips pre-contracted with Carbachol (HY-B1208). Its pD₂ value is 8.57 when the pre-contraction concentration of Carbachol is 0.1 μmol l^-1, and 7.69 when the pre-contraction concentration of Carbachol is 1.0 μmol l^-1[1].
Ro 25-1553 (1×10^-11 to 1×10^-6 mol l^-1) exerts an additive effect with Formoterol to relax isolated guinea pig tracheal smooth muscle strips pre-contracted by 0.1 μmol l^-1 Carbachol^[1].
Ro 25-1553 (1×10^-10 to 1×10^-4 mol l^-1) potently and completely inhibits vagus nerve-induced contractions in isolated guinea pig tracheal preparations; the pD₂ value is 8.31 when administered extraluminally and 6.32 when administered intraluminally^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3562.04

C₁₆₀H₂₅₈N₄₆O₄₆

159427-08-4

Ac-His-Ser-Asp-Ala-Val-Phe-Thr-Glu-Asn-Tyr-Thr-Lys-Leu-Arg-Lys-Gln-{Nle}-Ala-Ala-Lys-Lys-Tyr-Leu-Asn-Asp-Leu-Lys-Lys-Gly-Gly-Thr-NH2 (Lactam bridge:Lys21-Asp25)

Ac-HSDAVFTENYTKLRKQ-{Nle}-AAKKYLNDLKKGGT-NH2 (Lactam bridge:Lys21-Asp25)

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• [1]. Källström BL, et al. Bronchodilating properties of the VIP receptor agonist Ro 25-1553 compared to those of formoterol on the guinea-pig isolated trachea. Eur J Pharmacol. 2001;430(2-3):335-340.  [Content Brief]