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Results for "

pyruvate

" in MedChemExpress (MCE) Product Catalog:

標的別:	PDHK (21) Pyruvate Carboxylase (PC) (5) Pyruvate Kinase (46) AAK1 (1) Acetyl-CoA Carboxylase (1) Adenylate Cyclase (1) AIM2 (2) Amino Acid Derivatives (1) Antibiotic (1) Apoptosis (17) ATP Synthase (1) Autophagy (3) Bacterial (11) Biochemical Assay Reagents (21) Cannabinoid Receptor (1) Caspase (1) CDK (1) Chloride Channel (2) COX (3) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (1) DNA/RNA Synthesis (4) Drug Derivative (3) Drug Intermediate (1) Drug Metabolite (1) Endogenous Metabolite (40) Environmental Pollutants (1) ERK (1) Exosomes (2) Fatty Acid Synthase (FASN) (5) Ferroptosis (2) Fluorescent Dye (1) Fructose-1,6-bisphosphate aldolase (5) Fungal (5) Glutamate Dehydrogenase (GLDH) (1) Guanylate Cyclase (1) Herbicide (1) Hexokinase (3) HIF/HIF Prolyl-Hydroxylase (3) HIV (2) HPPD (1) HSP (1) Influenza Virus (1) Insecticide (1) Insulin Receptor (4) Interleukin Related (5) Isotope-Labeled Compounds (6) JNK (3) Lactate Dehydrogenase (16) LIM Kinase (LIMK) (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (17) MMP (1) Monocarboxylate Transporter (4) N-myristoyltransferase (1) NF-κB (6) NKCC (1) NO Synthase (5) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (2) OAT (1) Oxidative Phosphorylation (1) Parasite (6) PARP (1) PDK-1 (2) PGC-1α (1) Phosphatase (2) PPAR (4) PROTACs (1) Pyk2 (1) Pyroptosis (2) Reactive Oxygen Species (ROS) (13) Reference Standards (13) ROCK (1) Salt-inducible Kinase (SIK) (1) SGK (1) Sirtuin (3) SnRK (1) STAT (3) Tau Protein (1) TNF Receptor (4) Transketolase (1) Wee1 (1) Wnt (1) β-catenin (1) β-glucuronidase (1)
研究分野別:	Cancer (72) Cardiovascular Disease (10) Endocrinology (4) Infection (20) Inflammation/Immunology (28) Metabolic Disease (91) Neurological Disease (9)
クリックケミストリー:	Azide (1)

206

阻害剤およびアゴニスト

スクリーニングライブラリ

蛍光色素

生化学アッセイ試薬

MCE キット

天然物

組換えタンパク質

同位体標識化合物

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クリックケミストリー

Targets Recommended: Pyruvate Kinase Pyruvate Carboxylase (PC) PDHK

製品番号	製品名	Target	研究分野	構造式

HY-Y0445A

Sodium dichloroacetate 25+ Cited Publications	PDK-1 NKCC PDHK Reactive Oxygen Species (ROS) Apoptosis	Cancer
Sodium dichloroacetate is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor. Sodium dichloroacetate also stimulates pyruvate dehydrogenase (PDH) activity and works as a Na ⁺-K ⁺-2Cl ⁻ cotransporter (NKCC) inhibitor. Sodium dichloroacetate prevents the phosphorylation of the E1α subunit of PDC, promoting the entry of pyruvate into the mitochondria for oxidative metabolism, reducing lactate production, and simultaneously increasing the production of reactive oxygen species (ROS). Sodium dichloroacetate inhibits tumor cell proliferation and induces apoptosis. Sodium dichloroacetate is promising for research of cancers .

HY-15475

UK-5099 50+ Cited Publications PF-1005023	Mitochondrial Metabolism	Cancer
UK-5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 (PF-1005023) inhibits pyruvate-dependent O₂ consumption with an IC₅₀ of 50 nM.

HY-19992

3-Bromopyruvic acid 30+ Cited Publications Bromopyruvic acid; 3-BrPA; Hexokinase II Inhibitor II, 3-BP	Hexokinase Apoptosis Autophagy	Cancer
3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities .

HY-W015913

Pyruvic acid sodium 15+ Cited Publications Sodium 2-oxopropanoate; Acetylformic acid sodium	Reactive Oxygen Species (ROS) Endogenous Metabolite	Metabolic Disease
Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-107641

α-Cyano-4-hydroxycinnamic acid 10+ Cited Publications α-Cyano-4-hydroxycinnamate	Monocarboxylate Transporter	Metabolic Disease
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a K_i of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications .

HY-103617

PKM2-IN-1 25+ Cited Publications	Pyruvate Kinase	Cancer
PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC₅₀ of 2.95 μM .

HY-B1142

Lipoamide 5+ Cited Publications (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide	NO Synthase	Others
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .

HY-Y1362

Ethyl pyruvate 5+ Cited Publications	Autophagy Apoptosis Pyroptosis NF-κB	Inflammation/Immunology Cancer
Ethyl pyruvate is a simple derivative of the endogenous metabolite pyruvate. Ethyl pyruvate is an HMGB1 release inhibitor. Ethyl pyruvate can induce apoptosis by autophagy. Ethyl pyruvate has anti-inflammatory, antioxidant and anti-tumor activity. Ethyl pyruvate can be used in the study of neurodegenerative diseases such as Alzheimer's and Parkinson's disease .

HY-12689

Mitapivat 3 Publications Verification AG-348	Pyruvate Kinase	Metabolic Disease
Mitapivat (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of *PK (pyruvate* kinase)**-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency .

HY-134757

Lactate oxidase, Microorganism 2 Publications Verification	Endogenous Metabolite	Others
Lactate oxidase (EC 1.13.12.4) belongs to a group of FMN-dependent enzymes and they catalyze a conversion of lactate to pyruvate with a release of hydrogen peroxide. Lactate oxidase can be used in the detection of Lactate .

HY-D0713

7ACC2 5+ Cited Publications	Monocarboxylate Transporter Mitochondrial Metabolism	Cancer
7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC₅₀ of 11 nM for inhibition of [ ¹⁴C]-lactate influx. 7ACC2 is also a potent inhibitor of *mitochondrial pyruvate* transport**. 7ACC2 is an anticancer agent through inhibition of lactate flux .

HY-19330

DASA-58 15+ Cited Publications	Pyruvate Kinase	Metabolic Disease Cancer
DASA-58 is a potential pyruvate kinase isozyme (PKM2) allosteric activator. DASA-58 can be used for the research of metabolism and kinds of cancer .

HY-16082

AZD7545 4 Publications Verification	PDHK	Metabolic Disease
AZD7545 is a potent, competitive, selective PDHK2 (pyruvate dehydrogenase kinase 2) inhibitor with IC₅₀s of 36.8 nM, 6.4 nM for PDHK1 and PDHK2, respectively .

HY-P2985

Alanine aminotransferase, Porcine heart	Endogenous Metabolite	Metabolic Disease
Alanine aminotransferase, Porcine heart is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate .

HY-P2807I

L-Lactate Dehydrogenase, rabbit muscle	Lactate Dehydrogenase	Others
L-Lactate Dehydrogenase, rabbit muscle is a biological material or organic compound that can be used in life science research .

HY-142684

Pyruvate Carboxylase-IN-1 2 Publications Verification	Mitochondrial Metabolism	Cancer
Pyruvate Carboxylase-IN-1 (compound 37) is a potent pyruvate carboxylase inhibitor with antiproliferative activity. The IC₅₀ values of pyruvate carboxylase-IN-1 against PC in cell lysates and cells are 0.204 and 0.104 μM, respectively .

HY-163771

Pyruvate Carboxylase-IN-5	Pyruvate Carboxylase (PC)	Metabolic Disease
Pyruvate Carboxylase-IN-5 (compound 6m) is a pyruvate carboxylase inhibitor with high selectivity and permeability. Pyruvate carboxylase is a mitochondrial enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, a process that plays an important role in maintaining steady-state levels of Krebs cycle intermediates, which are precursors for the synthesis of biomacromolecules such as amino acids, fatty acids, and glucose .

HY-P2806

Pyruvate Kinase, Microorganism PK; Fluorokinase	Endogenous Metabolite	Metabolic Disease Cancer
Pyruvate Kinase, Microorganism (PK) is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP .

HY-100550

MSDC 0160 4 Publications Verification Mitoglitazone; CAY10415	Insulin Receptor Mitochondrial Metabolism	Neurological Disease Endocrinology
MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulating insulin sensitizer and a modulator of *mitochondrial pyruvate* carrier (MPC)**. MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimer′s disease .

HY-113076S

Thiamine pyrophosphate-d3	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Thiamine pyrophosphate-d₃ is the deuterium labeled Thiamine pyrophosphate. Thiamine pyrophosphate is the coenzyme form of Vitamin B1 and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.

HY-Y1939A

Metaphosphoric acid, 33.5-36.5% Glacial phosphoric acid, 33.5-36.5%	Biochemical Assay Reagents	Others
Metaphosphoric acid, 33.5-36.5% (Glacial phosphoric acid, 33.5-36.5%) is a precipitant used for rapid enzymatic measurement of blood lactate and pyruvate. Metaphosphoric acid, 33.5-36.5% can also be used as a dehydrating agent, and its derivative sodium hexametaphosphate can be used as a chelating agent and food additive .

HY-136882

TM-1	PDHK	Cancer
TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC₅₀s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation .

HY-P2914

Carnitine acetyltransferase	Biochemical Assay Reagents	Metabolic Disease Inflammation/Immunology
Carnitine acetyltransferase is a mitochondrial matrix enzyme that catalyzes the interconversion of Acetyl-CoA and Acetylcarnitine (HY-126358). Carnitine acetyltransferase functions as a positive regulator of total body glucose tolerance and muscle activity of pyruvate dehydrogenase. Carnitine acetyltransferase is responsible for mitochondrial acetyl-CoA balance and regulation of fatty acid oxidation by utilizing short- and medium- chain fatty acids and their corresponding acylcarnitines as substrates. Carnitine acetyltransferase plays a crucial role in regulating glucose homeostasis. Carnitine acetyltransferase can be utilized in the research of aging, obesity, and diabetes .

HY-161627

Anemoside A3-methyl 6-aminohexanoate	Pyruvate Carboxylase (PC) NOD-like Receptor (NLR) NF-κB Interleukin Related	Inflammation/Immunology
Anemoside A3-methyl 6-aminohexanoate is an orally effective pyruvate carboxylase (PC) inhibitor with a K_d value of 10.1 μM against human PC. Anemoside A3-methyl 6-aminohexanoate exerts its function through the PC/NF-κB/NLRP3 inflammasome axis. Anemoside A3-methyl 6-aminohexanoate significantly alleviates symptoms of DSS (HY-116282C)-induced colitis in mice. Anemoside A3-methyl 6-aminohexanoate can be used in colitis-related research .

HY-P2807

L-Lactate dehydrogenase, E.coli LAD	Endogenous Metabolite	Inflammation/Immunology Cancer
L-Lactate dehydrogenase, E.coli is a redox enzyme. L-Lactate dehydrogenase, E.coli catalyzes the reduction of pyruvate to L-lactate by NADH in vivo with absolute enantiospecificity .

HY-P2989

Pyruvate carboxylase	Endogenous Metabolite	Metabolic Disease Cancer
Pyruvate carboxylase is a key mitochondrial anaplerotic enzyme that catalyzes the conversion of pyruvate to oxaloacetate. Pyruvate carboxylase not only maintains tricarboxylic acid cycle activity and redox homeostasis, but also drives hepatic gluconeogenesis and fatty acid synthesis. The activity of Pyruvate carboxylase is upregulated in insulin-resistant states, exacerbating hepatic glucose production. Pyruvate carboxylase also shows significantly enhanced expression in early-stage non-small cell lung cancer (NSCLC). Pyruvate carboxylase promotes tumor proliferation by supporting nucleotide and lipid synthesis, and its functional deficiency cannot be compensated by glutaminolysis. Pyruvate carboxylase can be used in the research of prediabetes type 2 and NSCLC .

HY-P2806A

Pyruvate Kinase (PK),Rabbit Muscle ATP:pyruvate 2-0-phosphotransferase,PK	Pyruvate Kinase	Metabolic Disease Cancer
Pyruvate Kinase (PK),Rabbit Muscle (ATP:Pyruvate 2-0-phosphotransferase,PK) is a biological material or organic compound that can be used in life science research .

HY-138825

NCGC00188636	Pyk2	Metabolic Disease
NCGC00188636 is a novel covalent pyruvate kinase (PYK) inhibitor. NCGC00188636 blocks nucleotide binding to the active site of pyruvate kinase. NCGC00188636 can be used for the research of the metabolism of many organisms and cell types.

HY-135884

Tebapivat AG-946; PKR activator 2	Pyruvate Kinase	Cardiovascular Disease
Tebapivat (PKR activator 2) is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035863A1, compound 385 .

HY-113098

2-Oxovaleric acid	Lactate Dehydrogenase Drug Derivative	Metabolic Disease
2-Oxovaleric acid is an analog of Pyruvate and a substrate inhibitor of Lactate dehydrogenase, exhibiting substrate inhibitory activity against lactate dehydrogenase from Phycomyces blakesleeanus .

HY-139573

Etavopivat FT-4202	Pyruvate Kinase	Cardiovascular Disease
Etavopivat is a potent, selective, and orally active erythrocyte pyruvate kinase (PKR) activator. Etavopivat has potent antisickling effects that can be used in studies of sickle cell disease and other haemoglobinopathies .

HY-P2891

Pyruvate Oxidase, Microorganisms PoxB	Biochemical Assay Reagents	Others
Pyruvate Oxidase, Microorganisms (PoxB) is a peripheral membrane enzyme, isolated from microorganisms. Pyruvate oxidase catalyzes the oxidative decarboxylation of pyruvate to acetyl phosphate, carbon dioxide and water. Pyruvate oxidase is an important enzyme in bacterial metabolism and is often used in biochemical research .

HY-W012985

Methyl pyruvate	ATP Synthase Apoptosis	Metabolic Disease Cancer
Methyl pyruvate is a methyl ester derivative of pyruvic acid. Methyl pyruvate induces insulin release and membrane depolarization. Methyl pyruvate rescues proteasome damage and nuclear localization of TdP-43 caused by overexpression of σ1RE102Q by enhancing ATP synthesis. Methyl pyruvate selectively protects normal lung fibroblasts from cell death induced by Irinotecan (HY-16562). Methyl pyruvate promotes apoptosis and necrosis in cancer cells and downregulates angiogenesis and cell cycle pathways. Methyl pyruvate is an effective substrate for dihydrodihydrogen dehydrogenase.

HY-114702

M77976 2 Publications Verification	PDHK	Metabolic Disease
M77976 is a specific ATP-competitive inhibitor of *PDK4 (pyruvate* dehydrogenase kinase isoforms 4), with an IC₅₀** of 648 μM. M77976 is potential for the research of obesity and diabetes .

HY-138559

GW604714X 1 Publications Verification	Mitochondrial Metabolism	Neurological Disease
GW604714X is a potent inhibitor of mitochondrial respiration supported by pyruvate but not other substrates. GW604714X is a highly specific mitochondrial pyruvate carrier (MPC) inhibitor with a K_i <0.1 nM. GW604714X also inhibits L-lactate transport by the plasma membrane monocarboxylate transporter (MCT1), but at concentrations more than 4 orders of magnitude greater than the MPC .

HY-P2796

Pyruvate decarboxylase PDC	Biochemical Assay Reagents	Metabolic Disease
Pyruvate decarboxylase (PDC) is an enzyme that catalyses the decarboxylation of pyruvic acid to acetaldehyde. Pyruvate decarboxylase catalyses the non-oxidative conversion of pyruvate (or other 2-oxo acids) to acetaldehyde and CO₂ .

HY-19702

PKR activator 3	Pyruvate Kinase	Metabolic Disease
PKR activator 3 (Compound 160) is a red blood cell pyruvate kinase (PKR) activator. PKR activator 3 can be used in the research of diseases related to PKR function, such as pyruvate kinase deficiency (PKD) .

HY-161337

PKL-IN-1	Pyruvate Kinase	Metabolic Disease
PKL-IN-1 is a potent inhibitor of pyruvate kinase (PKL) with an IC₅₀ of 0.07 μM. PKL-IN-1 can be used in the study of non-alcoholic fatty liver disease .

HY-157395

malonyl-NAC 2 Publications Verification	Pyruvate Kinase	Cancer
malonyl-NAC increases cellular propylation, resulting in reduced endogenous GAPDH activity. malonyl-NAC increases GAPDH malonylation in cells and inhibits pyruvate kinase activity. In addition, malonyl-NAC limits the metabolism and proliferation of a highly glycolytic kidney cancer cell line harboring a tricarboxylic acid cycle mutation .

HY-N15451

Deoxytopsentin	Pyruvate Kinase	Infection
Deoxytopsentin (compound 5) is a marine bisindole alkaloid and also a MRSA pyruvate kinase inhibitor. Deoxytopsentin exists in sponges. Deoxytopsentin exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus strains in vitro .

HY-W250119

Calcium disodium edetate hydrate Maximum Cited Publications 24 Publications Verification EDTA disodium calcium salt hydrate; Ethylenediaminetetraacetic acid disodium calcium salt hydrate	Biochemical Assay Reagents Fungal Mitochondrial Metabolism	Infection
Calcium disodium edetate hydrate (EDTA disodium calcium salt hydrate) is a metal chelator and antifungal agent. Calcium disodium edetate hydrate chelates Mn ²⁺, damages mitochondria, and interferes with carbohydrate metabolic pathways, particularly the synthesis of pyruvate in glycolysis. Calcium disodium edetate hydrate inhibits Penicillium digitatum and delays conidial germination. Calcium disodium edetate (hydrate) enhances the host defense system of citrus fruits. Calcium disodium edetate hydrate is applicable to research related to citrus green mold .

HY-161679S

Pyruvate Carboxylase-IN-3	Isotope-Labeled Compounds	Cancer
Pyruvate Carboxylase-IN-3 (Compd 36) is a potent Pyruvate Carboxylase inhibitor. Pyruvate Carboxylase-IN-3 inhibits hepatocellular carcinoma cells activity with an IC₅₀ of 4.3 μM .

HY-161680

Pyruvate Carboxylase-IN-4	Pyruvate Carboxylase (PC)	Cancer
Pyruvate Carboxylase-IN-4 (Compd 8V) is a potent and competitive Pyruvate Carboxylase inhibitor with an IC₅₀ of 4.3 μM .

HY-P2977

N-Acetylneuraminate lyase (CgNal) Sialic acid aldolase (CgNal)	Fructose-1,6-bisphosphate aldolase Endogenous Metabolite	Others
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .

HY-128606

Thiamine diphosphate analog 1	Endogenous Metabolite Transketolase	Neurological Disease Metabolic Disease
Thiamine diphosphate analog 1 is an analog of thiamine diphosphate. Thiamine diphosphate is the active metabolite of vitamin B₁ in organisms. Thiamine diphosphate targets ThDP-dependent enzymes such as transketolase and pyruvate dehydrogenase complex, acting as an essential coenzyme to exert an activating effect. Thiamine diphosphate assists in catalytic reactions in free form and initiates the catalytic cycles of various glucose-metabolizing enzymes. Thiamine diphosphate serves as a diagnostic biomarker and protective factor for Alzheimer's disease. Thiamine diphosphate can be used in research related to metabolism and Alzheimer's disease .

HY-119874

Alkannin	Pyruvate Kinase	Inflammation/Immunology Cancer
Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent .

HY-12840

OBA-09	Reactive Oxygen Species (ROS)	Neurological Disease
OBA-09, a simple ester of pyruvate and salicylic acid, is potent multi-modal neuroprotectant. OBA-09 has anti-oxidative and anti-inflammatory effects .

HY-150287B

Insulin-Transferrin-Selenium-Sodium Pyruvate ITS-A	Biochemical Assay Reagents	Others
Insulin-Transferrin-Selenium-Sodium Pyruvate (ITS-A) is a basal media supplement used to reduce the amount of fetal bovine serum (FBS) used to culture cells.

HY-P2807K

L-Lactate Dehydrogenase, bovine muscle	Endogenous Metabolite	Metabolic Disease
L-Lactate Dehydrogenase, bovine muscle is an oxidoreductase. L-Lactate Dehydrogenase, bovine muscle catalyzes the reversible conversion of lactate to pyruvate with the reduction of NAD+ to NADH .

HY-161681

Formycin triphosphate	Guanylate Cyclase	Metabolic Disease
Formycin triphosphate is a fluorescent analogue of ATP which on binding to enzyme active sites exhibits enhanced fluorescence. Formycin triphosphate is an ATP-competitive chicken liver pyruvate carboxylase inhibitor. Formycin triphosphate potentiates atrial natriuretic factor (ANF)-stimulated guanylate cyclase activity with an EC₅₀ at about 90 μM and inhibits ATP-stimulated guanylate cyclase activity with an IC₅₀ at about 100 μM .

製品番号	製品名

HY-L058

Glycolysis Compound Library

1,296 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 1,296 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

HY-L092

Glucose Metabolism Compound Library

1,699 compounds

Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer.

MCE offers a unique collection of 1,699 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.

HY-L133

Cuproptosis Compound Library

419 compounds

Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".

The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.

Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.

MCE supplies a unique collection of 419 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

製品番号	製品名	Type

HY-W015913

Pyruvic acid sodium 15+ Cited Publications Sodium 2-oxopropanoate; Acetylformic acid sodium	生化学アッセイ試薬
Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-128851B

Coenzyme A sodium 2 Publications Verification	生化学アッセイ試薬
Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .

HY-128851A

Coenzyme A trilithium 2 Publications Verification	生化学アッセイ試薬
Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .

HY-Y1939A

Metaphosphoric acid, 33.5-36.5% Glacial phosphoric acid, 33.5-36.5%	生化学アッセイ試薬
Metaphosphoric acid, 33.5-36.5% (Glacial phosphoric acid, 33.5-36.5%) is a precipitant used for rapid enzymatic measurement of blood lactate and pyruvate. Metaphosphoric acid, 33.5-36.5% can also be used as a dehydrating agent, and its derivative sodium hexametaphosphate can be used as a chelating agent and food additive .

HY-W250119

Calcium disodium edetate hydrate

Maximum Cited Publications

24 Publications Verification

EDTA disodium calcium salt hydrate; Ethylenediaminetetraacetic acid disodium calcium salt hydrate

生化学アッセイ試薬

Calcium disodium edetate hydrate (EDTA disodium calcium salt hydrate) is a metal chelator and antifungal agent. Calcium disodium edetate hydrate chelates Mn ²⁺, damages mitochondria, and interferes with carbohydrate metabolic pathways, particularly the synthesis of pyruvate in glycolysis. Calcium disodium edetate hydrate inhibits Penicillium digitatum and delays conidial germination. Calcium disodium edetate (hydrate) enhances the host defense system of citrus fruits. Calcium disodium edetate hydrate is applicable to research related to citrus green mold .

HY-147064A

DL-4-Hydroxy-2-ketoglutarate	生化学アッセイ試薬
DL-4-Hydroxy-2-ketoglutarate serves as a substrate for the enzymes GOT (glutamic oxalacetic aminotransferase) and 2-keto-4-hydroxyglutarate aldolase, facilitating the reversible breakdown of 2-keto-4-hydroxyglutarate into pyruvate and glyoxylate; it has also found applications in mass spectrometry for the swift analysis of negatively charged, water-soluble cellular metabolites.

HY-150287B

Insulin-Transferrin-Selenium-Sodium Pyruvate ITS-A	生化学アッセイ試薬
Insulin-Transferrin-Selenium-Sodium Pyruvate (ITS-A) is a basal media supplement used to reduce the amount of fetal bovine serum (FBS) used to culture cells.

HY-W015913R

Pyruvic acid sodium (Standard) 5+ Cited Publications Sodium 2-oxopropanoate (Standard); Acetylformic acid sodium (Standard)	生化学アッセイ試薬
Sodium 2-oxopropanoate (Standard) is the analytical standard of Sodium 2-oxopropanoate. This product is intended for research and analytical applications. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

製品番号	製品名	Category	Target	構造式

HY-128851

Coenzyme A 2 Publications Verification	天然物 Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite Fatty Acid Synthase (FASN)
Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .

HY-N0822

Shikonin Maximum Cited Publications 66 Publications Verification C.I. 75535; Isoarnebin 4	Quinones Structural Classification Classification of Application Fields Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Boraginaceae Disease Research Fields Cancer	Exosomes Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

HY-W015913

Pyruvic acid sodium 15+ Cited Publications Sodium 2-oxopropanoate; Acetylformic acid sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) Endogenous Metabolite
Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-B1142

Lipoamide 5+ Cited Publications (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide	天然物 Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	NO Synthase
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .

HY-113076

Thiamine pyrophosphate 1 Publications Verification Cocarboxylase	Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases .

HY-126585

SAICAR 4 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC₅₀ of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions .

HY-113013

Hydroxypyruvic acid β-Hydroxypyruvic acid; 3-Hydroxypyruvic acid	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

HY-N1511

Ganoderic acid D 2 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Cancer	Sirtuin Apoptosis
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-112253

D-Fructose 1-phosphate	Structural Classification 天然物 Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite
D-Fructose 1-phosphate is a key intermediate metabolite in the fructose metabolic pathway. As a key signaling molecule linking fructose metabolism and glucose metabolic regulation, D-Fructose 1-phosphate acts as an allosteric modulator to counteract the inhibitory effect of the glucokinase-regulatory protein complex, thereby finely regulating the direction of hepatic glucose metabolism at the substrate level .

HY-113098

2-Oxovaleric acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Lactate Dehydrogenase Drug Derivative
2-Oxovaleric acid is an analog of Pyruvate and a substrate inhibitor of Lactate dehydrogenase, exhibiting substrate inhibitory activity against lactate dehydrogenase from Phycomyces blakesleeanus .

HY-112948

2-Methylbutyrylcarnitine	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-Methylbutyrylcarnitine is a fatty acid metabolite. 2-Methylbutyrylcarnitine is found mainly in the blood and urine of humans and animals and is produced through the pyruvate carboxylation pathway. 2-Methylbutyrylcarnitine exhibits high level in the plasma of subjects with steatohepatitis (NASH) and can be used as an indicator for the diagnosis of metabolic diseases .

HY-N15451

Deoxytopsentin	Structural Classification Alkaloids Marine natural products Sponge Indole Alkaloids Source Classification	Pyruvate Kinase
Deoxytopsentin (compound 5) is a marine bisindole alkaloid and also a MRSA pyruvate kinase inhibitor. Deoxytopsentin exists in sponges. Deoxytopsentin exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus strains in vitro .

HY-113076R

Thiamine pyrophosphate (Standard) Cocarboxylase (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Thiamine pyrophosphate (Standard) is the analytical standard of Thiamine pyrophosphate. This product is intended for research and analytical applications. Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases .

HY-128851R

Coenzyme A (Standard)	Structural Classification 天然物 Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Fatty Acid Synthase (FASN) Endogenous Metabolite
Coenzyme A (Standard) is the analytical standard of Coenzyme A. This product is intended for research and analytical applications. Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids[1].

HY-119874

Alkannin	Quinones Monophenols Ohwia caudata (Thunberg) H. Ohashi Classification of Application Fields Phenols Plants Compositae Naphthalene Quinones Inflammation/Immunology Disease Research Fields Source Classification	Pyruvate Kinase
Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent .

HY-N0822R

Shikonin (Standard) C.I. 75535 (Standard); Isoarnebin 4 (Standard)	Quinones Structural Classification Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Boraginaceae	Reference Standards Exosomes Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2
Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

HY-W134163

(E)-2-Octenal trans-2-Octenal	Structural Classification 天然物 Vitis vinifera cv. Zalema Plants Vitaceae Source Classification	Fungal Reactive Oxygen Species (ROS) Mitochondrial Metabolism Phosphatase Pyruvate Kinase
(E)-2-Octenal is an Antifungal agent. (E)-2-Octenal disrupts cell membrane integrity and causes ROS accumulation. (E)-2-Octenal decreases the activities of phosphofructokinase and pyruvate kinase. (E)-2-Octenal inhibits Neofusicoccum parvum growth by disrupting mitochondrial energy metabolism. (E)-2-Octenal suppresses the growth of a Prochloraz (HY-B0845)-resistant Penicillium italicum strain. (E)-2-octenal exerts a broad-spectrum and potent inhibitory effect on various fungi, including Sclerotium rolfsii, Metarhizium anisopliae sensu lato, and Aspergillus flavus, etc. (E)-2-Octenal can be used for the research of citrus blue mold and mango stem-end rot .

HY-W754527

Allithiamine Allithiamin	Structural Classification 天然物 Allium sativum L. Plants Amaryllidaceae Source Classification	Drug Derivative
Allithiamine is a thiamin derivative with absorption characteristics similar to fat-soluble vitamins. Allithiamine acts as a cofactor precursor for thiamin pyrophosphate (TPP), which participates in carbohydrate metabolism by supporting the pyruvate dehydrogenase (PDH) complex to facilitate pyruvate entry into the tricarboxylic acid (TCA) cycle as acetyl CoA. Allithiamine can be used for researching thiamin metabolism .

HY-W015913R

Pyruvic acid sodium (Standard) 5+ Cited Publications Sodium 2-oxopropanoate (Standard); Acetylformic acid sodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite
Sodium 2-oxopropanoate (Standard) is the analytical standard of Sodium 2-oxopropanoate. This product is intended for research and analytical applications. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-165154

Cyclamidomycin Desdanine; Pyracrimycin A	天然物 Microorganisms Source Classification	Antibiotic Bacterial Fungal Pyruvate Kinase Oxidative Phosphorylation
Cyclamidomycin (Desdanine) is an acrylamide antibiotic with antibacterial activity. Cyclamidomycin inhibits nucleoside diphosphate kinase and pyruvate kinase (in E. coli) and oxidative phosphorylation in rat liver mitochondria. Cyclamidomycin is active against S. aureus, M. flavus, S. lutea, B. subtilis, E. coli, S. flexneri, S. typhosa, P. vulgaris, and K. pneumoniae (MICs=3.12-25 mg/ml) .

HY-113013A

Hydroxypyruvic acid lithium hydrate β-Hydroxypyruvic acid lithium hydrate; 3-Hydroxypyruvic acid lithium hydrate	Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Hydroxypyruvic acid lithium hydrate (β-Hydroxypyruvic acid lithium hydrate) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid lithium hydrate is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid lithium hydrate is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

HY-N12016

Fulvotomentoside B	Triterpenes Caprifoliaceae Terpenoids Plants Lonicera macrantha (D. Don) Spreng. Saccharides Monosaccharides Source Classification	Others
Fulvotomentoside B is a saponin isolated from Lactobacillus flavus. Fulvotomentoside compounds can significantly reduce serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) levels in mice poisoned by CCl₄, d-galactosamine (d-gal) and acetaminophen, and significantly alleviate liver pathology. damage .

HY-N1511R

Ganoderic acid D (Standard)	Triterpenes Structural Classification Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants	Reference Standards Sirtuin Apoptosis
Ganoderic acid D (Standard) is the analytical standard of Ganoderic acid D. This product is intended for research and analytical applications. Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-180699

2-Oxo-3-sulfinopropanoic acid β-Sulfinyl pyruvate	Structural Classification 天然物 Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
2-Oxo-3-sulfinopropanoic acid (β-Sulfinyl pyruvate) is the reaction product of cysteine sulfinic acid deamination. 2-Oxo-3-sulfinopropanoic acid can be decomposed into pyruvate and sulfite .

HY-114625

Amquinate	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Parasite Mitochondrial Metabolism
Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrome-mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella. Amquinate can be used for the research of coccidiosis (Eimeria tenella infection) .

Species:	Human (14) Mouse (5) Rat (1) E.coli (1)
Tag:	SUMO (1) His (19) Tag Free (2) Myc (1) GST (6)
Source:	HEK293 (2) sf9 insect cells (1) Sf9 insect cells (7) P. pastoris (1) E. coli (12)

製品番号	Compare	製品名	Species	Source	Image

HY-P71458

	PpsA Protein, E.coli (His-SUMO) ppsA; pps; b1702; JW1692Phosphoenolpyruvate synthase; PEP synthase; EC 2.7.9.2; pyruvate; water dikinase	E.coli	E. coli
	The PpsA protein plays a crucial role in cellular metabolism by catalyzing the conversion of pyruvate to phosphoenolpyruvate, a key step in glycolysis and gluconeogenesis. This enzyme activity is the basis for the interconversion of metabolic intermediates and contributes to the regulation of intracellular energy production and utilization. PpsA Protein, E.coli (His-SUMO) is the recombinant E. coli-derived PpsA protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P700578

	PKLR Protein, Rat (P. pastoris, His) PKLR; pyruvate kinase, liver and RBC; PK1; PKL; PKR; RPK; PKRL; pyruvate kinase isozymes R/L; pyruvate kinase 1; OTTHUMP00000034069; pyruvate kinase type L; pyruvate kinase isozyme R/L; R-type/L-type pyruvate kinase; red cell/liver pyruvate kinase; pyruvate kinase, liver and blood cell; EC 2.7.1.40	Rat	P. pastoris
	The PKLR protein is a pyruvate kinase that plays a critical role in glycolysis, converting phosphoenolpyruvate to pyruvate and producing ATP.As a key enzyme, PKLR mediates the final steps of glycolysis, contributing to energy production.PKLR Protein, Rat (P.pastoris, His) is the recombinant rat-derived PKLR protein, expressed by P.pastoris , with N-6*His labeled tag.

HY-P71210

	PKLR Protein, Human (HEK293, His) pyruvate Kinase Isozymes R/L; pyruvate Kinase 1; R-Type/L-Type pyruvate Kinase; Red Cell/Liver pyruvate Kinase; PKLR; PK1; PKL	Human	HEK293
	The PKLR protein is a key enzyme in cellular metabolism that acts as a pyruvate kinase, converting phosphoenolpyruvate to pyruvate. This process is an integral part of glycolysis, the fundamental pathway for cellular energy production. PKLR Protein, Human (HEK293, His) is the recombinant human-derived PKLR protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P701737

	PDK4 Protein, Human (Active, GST) PDK4; [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4; mitochondrial; pyruvate dehydrogenase kinase isoform 4	Human	E. coli
	PDK4 Protein phosphorylates PDHA1 and PDHA2, inhibiting pyruvate dehydrogenase activity. This reduces glucose utilization, enhances fat metabolism, and helps maintain blood glucose levels during fasting. PDK4 also regulates fatty acid oxidation and biosynthesis, generates reactive oxygen species, protects epithelial cells, and regulates cell proliferation through metabolic regulation. PDK4 Protein, Human (GST) is the recombinant human-derived PDK4 protein, expressed by E. coli , with N-GST labeled tag.

HY-P71676

	PDCE2 Protein, Mouse (HEK293, His) 2 Publications Verification Dlat; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2	Mouse	HEK293
	PDCE2 Protein, a vital element in the pyruvate dehydrogenase complex, is integral to cellular metabolism. It catalyzes the conversion of pyruvate to acetyl-CoA and CO2, connecting glycolysis to the tricarboxylic acid (TCA) cycle. PDCE2's catalytic function is essential for efficient pyruvate utilization, ensuring the flow of carbon compounds through key metabolic pathways crucial for energy production and cellular homeostasis. PDCE2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PDCE2 protein, expressed by HEK293 , with N-10*His labeled tag.

HY-P702845

	PKM2 Protein, Human pyruvate kinase PKM; CTHBP; OIP-3; THBP1	Human	E. coli
	PKM2 Protein, Human is a recombinant PKM2 protein with no tagged. PKM2 Protein is one of the rate-limiting enzymes in glycolysis.

HY-P706083

	PDK1 Protein, Human (Active, sf9, His) [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; pyruvate dehydrogenase kinase isoform 1; PDH kinase 1; PDHK1	Human	Sf9 insect cells

HY-P704056

	PDK4 Protein, Mouse (221a.a, His) Pdk4; [pyruvate dehydrogenase; acetyl-transferring)] kinase isozyme 4; mitochondrial; EC 2.7.11.2; pyruvate dehydrogenase kinase isoform 4		E. coli
	PDK4 protein is a key kinase that regulates glucose and fatty acid metabolism by phosphorylating pyruvate dehydrogenase subunits PDHA1 and PDHA2.This inhibits pyruvate dehydrogenase activity, modulates metabolite flux and inhibits aerobic respiration.PDK4 Protein, Mouse (221a.a, His )is the recombinant mouse-derived PDK4 protein, expressed by E. coli , with N-6*His tag.

HY-P71614

	PDK3 Protein, Mouse (His) Pdk3; pyruvate dehydrogenase kinase isoform 3	Mouse	E. coli
	PDK3 is a metabolic regulator that inhibits pyruvate dehydrogenase through PDHA1 phosphorylation to fine-tune glucose metabolism and affect aerobic respiration. Phosphorylation of PDHA2 adds another layer of control. PDK3 Protein, Mouse (His) is the recombinant mouse-derived PDK3 protein, expressed by E. coli , with N-His labeled tag.

HY-P70599

	PKM2 Protein, Human (530a.a, His) pyruvate kinase PKM; CTHBP; OIP-3; THBP1	Human	E. coli
	PKM2 Protein, Human (530a.a, His) is a recombinant PKM2 protein with a His-Flag. PKM2 Protein is one of the rate-limiting enzymes in glycolysis.

HY-P74629

	PKM2 Protein, Mouse (sf9, His) pyruvate Kinase M2; PKM2; CTHBP; OIP-3; THBP1	Mouse	Sf9 insect cells
	PKM2 protein catalyzes the final step of glycolysis, transferring a phosphoryl group from PEP to ADP to generate ATP.In the nucleus, transcriptional activation of PKM2 contributes to cancer progression, promoting cell proliferation and tumorigenesis.PKM2 is also involved in caspase-independent cell death in tumors.PKM2 Protein, Mouse (sf9, His) is the recombinant mouse-derived PKM2 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P75286

	DLAT Protein, Human (sf9, His) pyruvate dehydrogenase complex component E2; PBC; PDC-E2; DLAT; DLTA	Human	Sf9 insect cells
	DLAT protein is an important component of the pyruvate dehydrogenase complex, which mainly promotes the conversion of pyruvate into acetyl-CoA and CO2. This enzymatic step establishes a critical link between glycolysis and the tricarboxylic acid (TCA) cycle. DLAT Protein, Human (sf9, His) is the recombinant human-derived DLAT protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P73718

	PDK1 Protein, Human (Inactive, sf9, His) pyruvate dehydrogenase kinase isoform 1; PDK1; PDHK1	Human	Sf9 insect cells
	PDK1 protein is a key kinase that controls glucose and fatty acid metabolism by phosphorylating pyruvate dehydrogenase subunits PDHA1 and PDHA2. This molecular switch inhibits pyruvate dehydrogenase, fine-tunes metabolite flux and downregulates aerobic respiration. PDK1 Protein, Human (sf9, His) is the recombinant human-derived PDK1 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P74639

	PDK4 Protein, Mouse (sf9, His-GST) pyruvate dehydrogenase kinase isoform 4; PDK4; PDHK4	Mouse	Sf9 insect cells
	PDK4 protein is a key kinase that regulates glucose and fatty acid metabolism by phosphorylating pyruvate dehydrogenase subunits PDHA1 and PDHA2.This inhibits pyruvate dehydrogenase activity, modulates metabolite flux and inhibits aerobic respiration.PDK4 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived PDK4 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P705854

	PDK2 Protein, Human (sf9, His-GST) PDHK2; pyruvate dehydrogenase kinase isoform 2 (PDH kinase 2; PDKII)	Human	sf9 insect cells

HY-P72053

	PKM2 Protein, Mouse (sf9, His, solution) Pkm; Pk3; Pkm2; Pykmpyruvate kinase PKM; EC 2.7.1.40; pyruvate kinase muscle isozyme	Mouse	Sf9 insect cells
	PKM2 protein catalyzes the final step of glycolysis, transferring a phosphoryl group from PEP to ADP to generate ATP.In the nucleus, transcriptional activation of PKM2 contributes to cancer progression, promoting cell proliferation and tumorigenesis.PKM2 is also involved in caspase-independent cell death in tumors.PKM2 Protein, Mouse (Baculovirus, His) is the recombinant mouse-derived PKM2 protein, expressed by Sf9 insect cells , with N-10*His labeled tag.

HY-P7803

	PKM2 Protein, Human (420a.a, His) 1 Publications Verification rHupyruvate Kinase M2/PKM2, His; pyruvate Kinase M2; PKM2; CTHBP; OIP-3; THBP1	Human	E. coli
	PKM2 Protein, Human (420a.a, His) is a multifunctional protein, is exclusively expressed in embryonic and adult dividing/tumor cells. PKM2 can catabolize glucose and involved in many nonglycolytic pathways.

HY-P704073

	PDHA1 Protein, Human (GST) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; PDHA1; PHE1A	Human	E. coli
	The PDHA1 protein is an important component of the pyruvate dehydrogenase complex and is responsible for coordinating the conversion of pyruvate to acetyl-CoA and CO2. It establishes an important link between glycolysis and the tricarboxylic acid (TCA) cycle, ensuring seamless integration of metabolic pathways. PDHA1 Protein, Human (GST) is the recombinant human-derived PDHA1 protein, expressed by E. coli, with N-GST labeled tag.

HY-P704072

	PDHA1 Protein, Human (His, Myc) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; PDHA1; PHE1A	Human	E. coli
	The PDHA1 protein is an important component of the pyruvate dehydrogenase complex and is responsible for coordinating the conversion of pyruvate to acetyl-CoA and CO2. It establishes an important link between glycolysis and the tricarboxylic acid (TCA) cycle, ensuring seamless integration of metabolic pathways. PDHA1 Protein, Human (His, Myc) is the recombinant human-derived PDHA1 protein, expressed by E. coli, with C-Myc and N-10*His labeled tag.

HY-P704071

	PDHA1 Protein, Human (His, GST) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; PDHA1; PHE1A	Human	E. coli
	The PDHA1 protein is an important component of the pyruvate dehydrogenase complex and is responsible for coordinating the conversion of pyruvate to acetyl-CoA and CO2. It establishes an important link between glycolysis and the tricarboxylic acid (TCA) cycle, ensuring seamless integration of metabolic pathways. PDHA1 Protein, Human (His, GST) is the recombinant human-derived PDHA1 protein, expressed by E. coli, with C-6*His and N-GST labeled tag.

HY-P702494

	GPT Protein, Human (His) AAT1; Alanine aminotransferase 1; Alanine aminotransferase; ALAT1_HUMAN; ALT1; Glutamate pyruvate transaminase 1; Glutamic alanine transaminase 1; Glutamic pyruvate transaminase (alanine aminotransferase); Glutamic pyruvic transaminase 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1; GPT 1; gpt; GPT1	Human	E. coli
	The GPT1 protein is a key player that catalyzes the reversible cleavage of L-arginine succinate, which is critical in the urea cycle, aids in hepatic nitrogen detoxification and promotes de novo L-arginine synthesis. GPT1 regulates intracellular and extracellular L-arginine pools, which are critical for nitrogen homeostasis. GPT Protein, Human (His) is the recombinant human-derived GPT1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P705581

	PDK1 Protein, Human (Inactive, sf9, His-GST) pyruvate dehydrogenase kinase isoform 1; PDH kinase 1 ; PDHK1; EC:2.7.11.2	Human	Sf9 insect cells

HY-P703444

	nanA Protein, S. haemolyticus sialic acid lyase; N-acetylneuraminate lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; nanA; Staphylococcus haemolyticus (strain JCSC1435); Lyase; 4.1.3.3	Others	E. coli
	nanA Protein, S. haemolyticus is the recombinant nanA protein, expressed by E. coli, with tag free tag.

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製品番号	製品名	構造式

HY-W015913S

Pyruvic acid-13C3 sodium 1 Publications Verification
Sodium 2-oxopropanoate- ¹³C₃ is the ¹³C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-113076S

Thiamine pyrophosphate-d3
Thiamine pyrophosphate-d₃ is the deuterium labeled Thiamine pyrophosphate. Thiamine pyrophosphate is the coenzyme form of Vitamin B1 and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.

HY-W015913S3

Pyruvic acid-13C-1 sodium
Sodium 2-oxopropanoate- ¹³C is the ¹³C labeled Sodium 2-oxopropanoate . Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-161679S

Pyruvate Carboxylase-IN-3
Pyruvate Carboxylase-IN-3 (Compd 36) is a potent Pyruvate Carboxylase inhibitor. Pyruvate Carboxylase-IN-3 inhibits hepatocellular carcinoma cells activity with an IC₅₀ of 4.3 μM .

HY-126585S

SAICAR-d3
SAICAR-d₃ is the deuterium labeled SAICAR. SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC₅₀ of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions .

HY-Y1362S

*Ethyl pyruvate-d3*
Ethyl pyruvate-d₃ is the deuterium labeled Ethyl pyruvate . Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate is an anti-inflammatory agent .

HY-W015913S1

Pyruvic acid-d3 sodium
Sodium 2-oxopropanoate-d₃ is the deuterium labeled Sodium 2-oxopropanoate . Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-W015913S4

Pyruvic acid-13C2-1 sodium
2-Oxopropanoate- ¹³C₂ (sodium) is the ¹³C labeled Sodium 2-oxopropanoate . Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-W753956

Iminostilbene-d10

Iminostilbene-d₁₀ is the deuterium labeled Iminostilbene (HY-N7064). Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases .

HY-12689S

Mitapivat-d8

Mitapivat-d₈ (AG-348-d₈) is the deuterium labeled Mitapivat (HY-12689). Mitapivat (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency.

HY-107641S

α-Cyano-4-hydroxycinnamic acid-d4

α-Cyano-4-hydroxycinnamic acid-d₄ (α-Cyano-4-hydroxycinnamate-d₄) is the deuterium labeled α-Cyano-4-hydroxycinnamic acid (HY-107641). α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a K_i of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications .

Host:	Mouse (14) Rabbit (16)
Reactivity:	Human (28) Bovine (1) Rat (19) Mouse (26) Monkey (3) Rabbit (1) human (2) Dog (1) Pig (1)
Application:	IHC-P (16) ICC/IF (25) IF-Tissue (2) IP (15) IHC-F (1) WB (29) FC (8) ELISA (7)
Isotype:	IgG (16) IgG1 (8)
Conjugation:	Non-conjugated (30)
Clonality:	Polyclonal (2) Monoclonal (17) Monoclonal Antibody (1) Recombinant (7)
Modification:	Phosphorylated (2) Unmodified (21)

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P83644

	Phospho-PKM2(Tyr105)Antibody PKM2 (Phospho Tyr105); PKM2 (Phospho Y105); PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; Pk3; PKL; PKLR; PKM 2; PKM; PYKM; pyruvate kinase 1; pyruvate kinase 2/3; pyruvate kinase 3; pyruvate kinase isozyme R/L; pyruvate kinase isozymes M1/M2; pyruvate kinase liver and blood cell; pyruvate kinase liver and RBC; pyruvate kinase liver and RBC type; pyruvate kinase M2; pyruvate kinase muscle; pyruvate kinase muscle isozyme; pyruvate kinase type L; R type/L type pyruvate kinase; Red cell/liver pyruvate kinase; RPK; TCB; THBP 1; THBP1; Thyroid hormone binding protein cytosolic; CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; Tumor M2-PK; p58; OIP-3.	IHC-P, IHC-F, ICC/IF, FC, ELISA	Human, Rat
	Phospho-PKM2(Tyr105)Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-PKM2(Tyr105).

HY-P81070

	Pyruvate Dehydrogenase E2 Antibody (YA912) 1 Publications Verification DLAT; DLTA; E2; PBC; PDCE2; pyruvate Dehydrogenase E2	WB, ICC/IF, IP	Human, Mouse
	Pyruvate Dehydrogenase E2 Antibody (YA912) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Pyruvate Dehydrogenase E2.

HY-P80292

	Pyruvate Dehydrogenase E2 Antibody (YA113)	WB, IHC-P	Human, Mouse, Rat
	Pyruvate Dehydrogenase E2 Antibody (YA113) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Pyruvate Dehydrogenase E2.

HY-P810906

	Pyruvate Carboxylase Antibody Pyruvic carboxylase, PCB, PC	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Pyruvate Carboxylase Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Pyruvate Carboxylase.

HY-P80878

	Pyruvate Dehydrogenase E1 alpha Antibody (YA681) mitochondrial; ODPA_HUMAN; PDH; PDHA; PDHA1; PDHCE1A; PDHE1 A type I; PDHE1-A type I; PHE1A; pyruvate Dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase complex; E1 alpha polypeptide 1; pyruvate Dehydrogenase E1 alpha; pyruvate dehydrogenase E1 com	WB, ICC/IF	Human, Mouse
	Pyruvate Dehydrogenase E1 alpha Antibody (YA681) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 alpha.

HY-P81070A

	Pyruvate Dehydrogenase E2 Antibody (YA912)(PBS only) DLAT; DLTA; E2; PBC; PDCE2; pyruvate Dehydrogenase E2	WB, ICC/IF, IP	Human, Mouse
	Pyruvate Dehydrogenase E2 Antibody (YA912) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Pyruvate Dehydrogenase E2.

HY-P85504

	Pyruvate Dehydrogenase E1 alpha Antibody (YA5196) mitochondrial; ODPA_HUMAN; PDH; PDHA; PDHA1; PDHCE1A; PDHE1 A type I; PDHE1-A type I; PHE1A; pyruvate Dehydrogenase; lipoamide; alpha 1; pyruvate dehydrogenase complex, E1 alpha polypeptide 1; pyruvate Dehydrogenase E1 alpha; pyruvate dehydrogenase E1 component subunit alpha; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; somatic form.	WB, ICC/IF	Human, Mouse
	Pyruvate Dehydrogenase E1 alpha Antibody (YA5196) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 alpha.

HY-P80878A

	Pyruvate Dehydrogenase E1 alpha Antibody (YA681)(PBS only) mitochondrial; ODPA_HUMAN; PDH; PDHA; PDHA1; PDHCE1A; PDHE1 A type I; PDHE1-A type I; PHE1A; pyruvate Dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase complex; E1 alpha polypeptide 1; pyruvate Dehydrogenase E1 alpha; pyruvate dehydrogenase E1 com	WB, ICC/IF	Human, Mouse
	Pyruvate Dehydrogenase E1 alpha Antibody (YA681) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 alpha.

HY-P85556

	Pyruvate Dehydrogenase E2 Antibody (YA5248) 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; anti DLAT; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide; Dihydrolipoamide S Acetyltransferase; Dihydrolipoamide S-acetyltransferase; E2 component of pyruvate dehydrogenase complex; Dihydrolipoamide S-Acetyltransferase; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial; DLAT; DLAT; DLTA; E2; E2 component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; M2 Antigen Complex 70kD Subunit; mitochondrial; ODP2_HUMAN; PBC; PDC E2; PDC-E2; PDCE2; pyruvate dehydrogenase complex component E2; pyruvate dehydrogenase complex E2 subunit; S acetyltransferase component of pyruvate dehydrogenase complex.	WB, ICC/IF, IP	Human, Mouse
	Pyruvate Dehydrogenase E2 Antibody (YA5248) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Pyruvate Dehydrogenase E2.

HY-P80291

	Pyruvate Dehydrogenase E1 beta subunit Antibody (YA114)	WB, IHC-P, FC, IP	Human, Mouse, Rat
	Pyruvate Dehydrogenase E1 beta subunit Antibody (YA114) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 beta subunit.

HY-P81650

	PDK2 Antibody (YA1395) PDK2; PDHK2; [pyruvate dehydrogenase [lipoamide]] kinase isozyme 2; mitochondrial; pyruvate dehydrogenase kinase isoform 2	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	PDK2 Antibody (YA1395) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDK2.

HY-P85321

	PDK1 Antibody (YA5013) PDK1; PDHK1; [pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; mitochondrial; pyruvate dehydrogenase kinase isoform 1	WB, IP	Human, Mouse, Rat
	PDK1 Antibody (YA5013) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to PDK1.

HY-P810637

	Phospho-PDHA1 (Ser293) Antibody (YA9899) mitochondrial; ODPA_HUMAN; PDH; PDHA; PDHA1; PDHCE1A; PDHE1 A type I; PDHE1-A type I; PHE1A; pyruvate Dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase complex; E1 alpha polypeptide 1; pyruvate Dehydrogenase E1 alpha; pyruvate dehydrogenase E1 com	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Phospho-PDHA1 (Ser293) Antibody (YA9899) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-PDHA1 (Ser293).

HY-P82315

	PCB Antibody (YA2060) PC; pyruvate carboxylase; mitochondrial; Pyruvic carboxylase; PCB	WB, ICC/IF	Human, Mouse, Rat
	PCB Antibody (YA2060) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCB.

HY-P85449

	Pyruvate Dehydrogenase E1 alpha Antibody (YA5141) PDHA1; PHE1A; pyruvate dehydrogenase E1 component subunit alpha; somatic form, mitochondrial; PDHE1-A type I	WB, ICC/IF	Human, Mouse, Rat, Bovine, Dog, Pig
	Pyruvate Dehydrogenase E1 alpha Antibody (YA5141) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 alpha.

HY-P86544

	Pyruvate Dehydrogenase E1 alpha Antibody (YA6236) PDHA1; PHE1A; pyruvate dehydrogenase E1 component subunit alpha; somatic form, mitochondrial; PDHE1-A type I	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Pyruvate Dehydrogenase E1 alpha Antibody (YA6236) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 alpha.

HY-P89698

	PDK4 Antibody (YA9042) pyruvate dehydrogenase kinase isoform 4, Pdk4	WB, ICC/IF, IF-Tissue, IP, ELISA	human
	PDK4 Antibody (YA9042) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDK4.

HY-P85551

	PKM2 Antibody (YA5243) CTHBP; Cytosolic thyroid hormone binding protein; Cytosolic thyroid hormone-binding protein; KPYM_HUMAN; MGC3932; OIP 3; OIP-3; OIP3; OPA interacting protein 3; Opa-interacting protein 3; p58; PK muscle type; PK, muscle type; PK2; PK3; PKM; PKM2; pykm; pyruvate kinase 2/3; pyruvate kinase 3; pyruvate kinase isozymes M1/M2; pyruvate kinase muscle; pyruvate kinase muscle isozyme; pyruvate kinase PKM; pyruvate kinase, muscle 2; TCB; THBP1; Thyroid hormone binding protein 1; Thyroid hormone binding protein cytosolic; Thyroid hormone-binding protein 1; Tumor M2 PK; Tumor M2-PK .	WB, ICC/IF, IP	Human, Mouse, Monkey
	PKM2 Antibody (YA5243) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PKM2.

HY-P85552

	PKM2 Antibody (YA5244) CTHBP; Cytosolic thyroid hormone binding protein; Cytosolic thyroid hormone-binding protein; KPYM_HUMAN; MGC3932; OIP 3; OIP-3; OIP3; OPA interacting protein 3; Opa-interacting protein 3; p58; PK muscle type; PK, muscle type; PK2; PK3; PKM; PKM2; pykm; pyruvate kinase 2/3; pyruvate kinase 3; pyruvate kinase isozymes M1/M2; pyruvate kinase muscle; pyruvate kinase muscle isozyme; pyruvate kinase PKM; pyruvate kinase, muscle 2; TCB; THBP1; Thyroid hormone binding protein 1; Thyroid hormone binding protein cytosolic; Thyroid hormone-binding protein 1; Tumor M2 PK; Tumor M2-PK.	WB, ICC/IF	Human, Mouse, Rat, Monkey
	PKM2 Antibody (YA5244) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PKM2.

HY-P80870

	PKM2 Antibody 2 Publications Verification PKM; OIP3; PK2; PK3; PKM2; pyruvate kinase isozymes M1/M2; Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; pyruvate kinase 2/3; pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tu	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	PKM2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PKM2.

HY-P85448

	Pyruvate Dehydrogenase E2 Antibody (YA5140) DLAT; DLTA; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; mitochondrial; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; Dihydrolipoamide acetyltransferase component of pyruva	WB	Human, Rabbit
	Pyruvate Dehydrogenase E2 Antibody (YA5140) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Pyruvate Dehydrogenase E2.

HY-P86631

	PKM Antibody (YA6323) PKM; OIP3; PK2; PK3; PKM2; pyruvate kinase isozymes M1/M2; Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; pyruvate kinase 2/3; pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tu	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PKM Antibody (YA6323) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKM.

HY-P84011

	Pyruvate Dehydrogenase E1 alpha Antibody (YA3708) PDHA; PDHAD; PHE1A; PDHCE1A	WB, IP, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	Pyruvate Dehydrogenase E1 alpha Antibody (YA3708) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 alpha.

HY-P84011A

	Pyruvate Dehydrogenase E1 alpha Antibody (YA3708)(PBS only) PDHA; PDHAD; PHE1A; PDHCE1A	WB, IP, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	Pyruvate Dehydrogenase E1 alpha Antibody (YA3708) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 alpha.

HY-P82629

	Pyruvate Dehydrogenase E1 beta Antibody (YA2374) pdhB; DHBD; PDHE1 B; PDHE1-B; PHE1B	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
	Pyruvate Dehydrogenase E1 beta Antibody (YA2374) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 beta.

HY-P89693

	E3BP Antibody (YA9037) DLTA, DLAT, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, M2 antigen complex 70 kDa subunit, pyruvate dehydrogenase complex component E2, PBC, PDC-E2, PDCE2	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human
	E3BP Antibody (YA9037) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to E3BP.

HY-P87012

	PKM2 Antibody (YA6705) CTHBP antibody; Cytosolic thyroid hormone-binding protein antibody; KPYM_HUMAN antibody; OIP-3 antibody; Opa-interacting protein 3 antibody; p58 antibody; pkm antibody; PKM1 antibody; PKM2 antibody; pyruvate kinase 2/3 antibody; CTHBP antibody; Cytosolic thyroid hormone-binding protein antibody; KPYM_HUMAN antibody; OIP-3 antibody; Opa-interacting protein 3 antibody; p58 antibody; pkm antibody; PKM1 antibody; PKM2 antibody; pyruvate kinase 2/3 antibody; pyruvate kinase muscle isozyme antibody; pyruvate kinase PKM antibody; THBP1 antibody; Thyroid hormone-binding protein 1 antibody; Tumor M2-PK antibody;	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat, Monkey
	PKM2 Antibody (YA6705) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKM2.

HY-P811072

	BRP44L Antibody BRP44L, CGI-129, HSPC040, PNAS-115, MPC1, Mitochondrial pyruvate carrier 1, Brain protein 44-like protein	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	BRP44L Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to BRP44L.

HY-P811047

	PDP1 Antibody PDP, PPM2C, PDP1, PDP 1, Protein phosphatase 2C, pyruvate dehydrogenase phosphatase catalytic subunit 1, PDPC 1	WB, ICC/IF	Human, Mouse
	PDP1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to PDP1.

HY-P811265

	GPT Antibody AAT1, GPT1, GPT, Alanine aminotransferase 1, ALT1, Glutamate pyruvate transaminase 1, Glutamic--alanine transaminase 1, Glutamic--pyruvic transaminase 1, GPT 1	WB, IHC-P	Human, Mouse, Rat
	GPT Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to GPT.

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製品番号	製品名		Classification

HY-159095

PKR activator 5		Azide
PKR activator 5 (Compound 18) is an activator for pyruvate kinase R (PKR) with an AC₅₀ of 28 nM .

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