2,5-Anhydro-D-glucitol-1,6-diphosphate
Based on 1 Customer Validation
2,5-Anhydro-D-glucitol-1,6-diphosphate is a competitive PFK-1 inhibitor. 2,5-Anhydro-D-glucitol-1,6-diphosphate inhibits the enzymatic activity of PFKP without altering the non-glycolytic regulatory function of PFKP. 2,5-Anhydro-D-glucitol-1,6-diphosphate does not change mitochondrial AMPK levels, ACC2 phosphorylation levels, long-chain free fatty acid levels, or ROS levels under glucose starvation conditions. 2,5-Anhydro-D-glucitol-1,6-diphosphate is used in related research on non-small cell lung cancer.
For research use only. We do not sell to patients.
- Purity : 99.49%
- CAS No.: 4429-47-4
- Formula: C6H14O11P2
- Molecular Weight:324.12
-
Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
2,5-Anhydro-D-glucitol-1,6-diphosphate is a potent competitive inhibitor of rat liver PFK-1[2].
Inhibition of PFKP catalytic activity mediated by 2,5-Anhydro-D-glucitol-1,6-diphosphate does not affect the PFKP-regulated mitochondrial AMPK-ACC2 signaling axis, long-chain fatty acid oxidation, or redox homeostasis in H1703 non-small cell lung cancer cells under glucose starvation conditions[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 4429-47-4
-
Appearance Oil
-
Molecular Weight 324.12
-
Formula C6H14O11P2
-
Color Colorless to light yellow
-
SMILES
O[C@H]1[C@H](O)[C@H](COP(O)(O)=O)O[C@@H]1COP(O)(O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
-
Data Sheet (267 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Wurster B, et al. Tautomeric and anomeric specificity of allosteric activation of yeast pyruvate kinase by D-fructose 1, 6-bisphosphate and its relevance in D-glucose catabolism. FEBS Lett. 1976 Mar 15;63(1):17-21. [Content Brief]
[2]. Lang L, et al. PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism. Advances in experimental medicine and biology. 2019;1134:243-258. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2,5-Anhydro-D-glucitol-1,6-diphosphate Related Classifications
HY-134177 Related Classifications
Powered by Bioz