PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism

  • Adv Exp Med Biol. 2019:1134:243-258. doi: 10.1007/978-3-030-12668-1_13.
Liwei Lang  1 ,  Ron Chemmalakuzhy  2 ,  Chloe Shay  3  4 ,  Yong Teng  5  6  7
Affiliations
  • 1. Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.
  • 2. Department of Biology, College of Science and Mathematics, Augusta University, Augusta, GA, USA.
  • 3. The Robinson College of Business, Georgia State University, Atlanta, GA, USA.
  • 4. Division of Endocrinology and Diabetes, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.
  • 5. Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA. [email protected].
  • 6. Georgia Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA. [email protected].
  • 7. Department of Medical Laboratory, Imaging and Radiologic Sciences, College of Allied Health, Augusta University, Augusta, GA, USA. [email protected].
PMID: 30919341 DOI: 10.1007/978-3-030-12668-1_13
Abstract

Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of Glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of Cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant Tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of Cancer is also discussed.

Keywords
Biologic roles; Cancer; Diagnostic marker; Drug target; Gene regulations; PFKP.
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