4429-47-4
Chemical Structure
2,5-Anhydro-D-glucitol-1,6-diphosphate
- CAS No.: 4429-47-4
- Formula:C6H14O11P2
- Molecular Weight:324.12
IUPAC Name: ((2R,3S,4S,5S)-3,4-dihydroxytetrahydrofuran-2,5-diyl)bis(methylene) bis(dihydrogen phosphate)
InChIKey: WSMBXSQDFPTODV-JGWLITMVSA-N
SMILES: O[C@H]1[C@H](O)[C@H](COP(O)(O)=O)O[C@@H]1COP(O)(O)=O
Biological Activity: 2,5-Anhydro-D-glucitol-1,6-diphosphate is a competitive PFK-1 inhibitor. 2,5-Anhydro-D-glucitol-1,6-diphosphate inhibits the enzymatic activity of PFKP without altering the non-glycolytic regulatory function of PFKP. 2,5-Anhydro-D-glucitol-1,6-diphosphate does not change mitochondrial AMPK levels, ACC2 phosphorylation levels, long-chain free fatty acid levels, or ROS levels under glucose starvation conditions. 2,5-Anhydro-D-glucitol-1,6-diphosphate is used in related research on non-small cell lung cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2,5-Anhydro-D-glucitol-1,6-diphosphate | 99.49% | 2,5-Anhydro-D-glucitol-1,6-diphosphate is a competitive PFK-1 inhibitor. 2,5-Anhydro-D-glucitol-1,6-diphosphate inhibits the enzymatic activity of PFKP without altering the non-glycolytic regulatory function of PFKP. 2,5-Anhydro-D-glucitol-1,6-diphosphate does not change mitochondrial AMPK levels, ACC2 phosphorylation levels, long-chain free fatty acid levels, or ROS levels under glucose starvation conditions. 2,5-Anhydro-D-glucitol-1,6-diphosphate is used in related research on non-small cell lung cancer. | ||||||||||||||||||||
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References
- [1]. Wurster B, et al. Tautomeric and anomeric specificity of allosteric activation of yeast pyruvate kinase by D-fructose 1, 6-bisphosphate and its relevance in D-glucose catabolism. FEBS Lett. 1976 Mar 15;63(1):17-21. [Content Brief]
- [2]. Lang L, et al. PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism. Advances in experimental medicine and biology. 2019;1134:243-258. [Content Brief]
- [3]. Chen J, et al. PFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation. Cell discovery. 2022 May 31;8(1):52.
