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Alkannin 

Cat. No.: HY-119874
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Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent.

For research use only. We do not sell to patients.

Alkannin Chemical Structure

Alkannin Chemical Structure

CAS No. : 23444-65-7

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Description

Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent[1].

In Vitro

Alkannin is a potent and specific inhibitor to PKM2, an enzyme that dictates the last rate-limiting step of glycolysis, which is essential for cancer cells’ proliferation and survival. In the absence of D-fructose-1,6-bisphosphate (FBP), the IC50 of Alkannin is 0.3 μM. In the presence of FBP (125 μM), the IC50 of Alkannin is 0.9 μM, respectively. Alkannin effectively inhibits the cellular glycolytic flux in cancer cells dominantly expressing PKM2[1].
Alkannin (2.5-20 μM, 1 hour) inhibit the rates of cellular lactate production and glucose consumption[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MCF-7 and A549 express PKM2 but not PKM1 and PKL
Concentration: 0-20 μM
Incubation Time: 1 hour
Result: Inhibited the cellular glycolytic rate in a concentration-dependent manner.
Molecular Weight

288.30

Formula

C16H16O5

CAS No.
SMILES

OC1=C(C=C(C2=C1C(C=CC2=O)=O)O)[[email protected]](C/C=C(C)\C)O

Structure Classification
Source
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Alkannin
Cat. No.:
HY-119874
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