Alkannin

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Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent.

For research use only. We do not sell to patients.

Alkannin Chemical Structure

CAS No. : 23444-65-7

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5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

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Other Forms of Alkannin:

Shikonin In-stock
(-)-Alkannin In-stock

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Description

Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent^[1].

In Vitro

Alkannin is a potent and specific inhibitor to PKM2, an enzyme that dictates the last rate-limiting step of glycolysis, which is essential for cancer cells’ proliferation and survival. In the absence of D-fructose-1,6-bisphosphate (FBP), the IC₅₀ of Alkannin is 0.3 μM. In the presence of FBP (125 μM), the IC₅₀ of Alkannin is 0.9 μM, respectively. Alkannin effectively inhibits the cellular glycolytic flux in cancer cells dominantly expressing PKM2^[1].
Alkannin (2.5-20 μM, 1 hour) inhibit the rates of cellular lactate production and glucose consumption^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	MCF-7 and A549 express PKM2 but not PKM1 and PKL
Concentration:	0-20 μM
Incubation Time:	1 hour
Result:	Inhibited the cellular glycolytic rate in a concentration-dependent manner.

Molecular Weight

288.30

Formula

C₁₆H₁₆O₅

CAS No.

23444-65-7

SMILES

OC1=C(C=C(C2=C1C(C=CC2=O)=O)O)[C@H](C/C=C(C)\C)O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. J Chen, et al. Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene. 2011 Oct 20;30(42):4297-306. [Content Brief]

Alkannin Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alkannin23444-65-7Pyruvate KinaseRas-induced transcriptionRas-Erk-1/2 pathwayrefractory asthmaRas/Erk activationmicrotubulesInhibitorinhibitorinhibit

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