ZY-2

Cat. No.: HY-D1876: FAQs
Data Sheet Handling Instructions

Molarity Calculator

ZY-2 is a specific fluorescent probe for pyruvate kinase M2 (PKM2). ZY-2 can image in PKM2-positive cells in a time- and concentration-dependent manner. ZY-2 can be used for the detection of cancer cells.

For research use only. We do not sell to patients.

ZY-2 Chemical Structure

Size		Stock
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

819.91

Formula

C₄₀H₄₀F₃N₇O₅S₂

SMILES

CN1C2=C(SC(S(C)=O)=C2)C3=C1C(N(N=C3)CC4=CC(NC(CN5CCN(C6=CC=C(C=C6)/C=C/C7=CC=[N+](CC)C=C7)CC5)=O)=CC=C4)=O.[O-]C(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (121.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2196 mL	6.0982 mL	12.1965 mL
5 mM	0.2439 mL	1.2196 mL	2.4393 mL
10 mM	0.1220 mL	0.6098 mL	1.2196 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. A responsive fluorescent probe for detecting and imaging pyruvate kinase M2 in live cells. Chem Commun (Camb). 2022, 58(45): 6494-6497.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2196 mL	6.0982 mL	12.1965 mL	30.4912 mL
	5 mM	0.2439 mL	1.2196 mL	2.4393 mL	6.0982 mL
	10 mM	0.1220 mL	0.6098 mL	1.2196 mL	3.0491 mL
	15 mM	0.0813 mL	0.4065 mL	0.8131 mL	2.0327 mL
	20 mM	0.0610 mL	0.3049 mL	0.6098 mL	1.5246 mL
	25 mM	0.0488 mL	0.2439 mL	0.4879 mL	1.2196 mL
	30 mM	0.0407 mL	0.2033 mL	0.4065 mL	1.0164 mL
	40 mM	0.0305 mL	0.1525 mL	0.3049 mL	0.7623 mL
	50 mM	0.0244 mL	0.1220 mL	0.2439 mL	0.6098 mL
	60 mM	0.0203 mL	0.1016 mL	0.2033 mL	0.5082 mL
	80 mM	0.0152 mL	0.0762 mL	0.1525 mL	0.3811 mL
	100 mM	0.0122 mL	0.0610 mL	0.1220 mL	0.3049 mL

ZY-2 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZY-2ZY2ZY 2Fluorescent DyecancerInhibitorinhibitorinhibit

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