PKM2-IN-11
PKM2-IN-11 is a PKM2 inhibitor (IC50 = 0.363 μM). PKM2-IN-11 has dual mechanisms involving pyruvate kinase M2 (PKM2) inhibition and microtubule stabilization. PKM2-IN-11 can decrease PKM2 protein levels in MCF-7 cells. PKM2-IN-11 can slightly reduce reactive oxygen species (ROS) levels and significantly increase early apoptotic cells. PKM2-IN-11 induces G2/M phase arrest. PKM2-IN-11 can be used for the study of breast cancer.
For research use only. We do not sell to patients.
- Formula: C21H19IO4
- Molecular Weight:462.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PKM2 0.363 μM (IC50) |
PKM2-IN-11 (Compound 30o) (1-25 μM, 24 h) exhibits potent antiproliferative activity (IC50 = 10.2 μM) against MCF-7 cells and shows no cytotoxic effect on HEK-293 cells[1].
PKM2-IN-11 (1-5 μM) results in a dose-dependent decrease in PKM2 protein levels in MCF-7 cells[1].
PKM2-IN-11 (5 μM) increases the microtubule polymerization rate (Vmax) and stabilizes microtubule growth[1].
PKM2-IN-11 slightly reduces ROS levels and induces mitochondrial membrane potential (ΔΨm) depolarization, resulting in a decrease in the red/green fluorescence ratio in MCF-7 cells[1].
PKM2-IN-11 (5 μM) induces a significant increase in early apoptotic cells, with a low proportion of late apoptotic cells, and leads to G2/M phase arrest (23 %) in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:1 μM, 5 μM, 10 μM, 25 μM
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Incubation Time:24 h
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Result:Exhibited potent antiproliferative activity (IC50 = 10.2 ± 0.07 μM) against MCF-7 cells.
Chemical Information
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Molecular Weight 462.28
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Formula C21H19IO4
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SMILES
CC1(C)C=CC2=C(C=CC(/C=C/C(C3=CC=C(OC)C(I)=C3)=O)=C2O)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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