Mitapivat hemisulfate
Based on 3 publication(s) in Google Scholar
Mitapivat hemisulfate is an orally active pyruvate kinase allosteric activator. Mitapivat hemisulfate increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat hemisulfate can be used in study of PK deficiency.
For research use only. We do not sell to patients.
- CAS No.: 2329710-91-8
- Formula: C24H26N4O3S.1/2H2SO4
- Molecular Weight:499.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Mitapivat hemisulfate
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PK/PD Analysis
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Chemical Information
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CAS No. 2329710-91-8
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Molecular Weight 499.60
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Formula C24H26N4O3S.1/2H2SO4
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SMILES
O=C(N1CCN(CC2CC2)CC1)C3=CC=C(NS(=O)(C4=CC=CC5=CC=CN=C54)=O)C=C3.O=S(O)(O)=O.[0.5]
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Synonyms
AG-348 hemisulfate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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J Sep Sci
Development and validation of stability indicating assay method for mitapivat: Identification of novel hydrolytic, photolytic, and oxidative forced degradation products employing quadrupole-time of flight mass spectrometry. [Abstract]2024 Jul;47(14):e2400173. PMID: 39054589 -
J Mass Spectrom
Identification of Mitapivat's In Vivo Metabolites in the Rat Model by Quadrupole-Time-of-Flight (Q-TOF) Mass Spectrometry. [Abstract]2025 May;60(5):e5126. PMID: 40195624 -
Mitapivat hemisulfate purchased from MedChemExpress. Usage Cited in: Sep Sci Plus. 2025 Jan 07.
Mean plasma concentration–time profile and log-plasma concentration–time profile of Mitapivat after a single oral dose of 5 mg/kg to SD rats (each data point corresponds to mean ± S.D., n = 4).
Purity & Documentation
References
[1]. Kung C, et al. AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency. Blood. 2017 Sep 14;130(11):1347-1356. [Content Brief]
[2]. Matte A, et al. The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model. J Clin Invest. 2021 May 17;131(10):e144206. [Content Brief]
[3]. Rab MAE, et al. AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes. Haematologica. 2021 Jan 1;106(1):238-249. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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