2. Metabolic Enzyme/Protease
  3. Pyruvate Kinase
  4. NPD10084

NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and β-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo.

For research use only. We do not sell to patients.

NPD10084 Chemical Structure

NPD10084 Chemical Structure

CAS No. : 1040706-91-9

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NPD10084 Related Antibodies

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Description

NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and β-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo[1].

IC50 & Target

Pyruvate kinase muscle isoform 2 (PKM2)[1]
Molecular Weight

345.39

Formula

C21H19N3O2
CAS No.
SMILES

COC1=CC=CC2=C1C=C(C(N3CCC4=C(C5=CC=CC=C5N4)C3)=O)N2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NPD10084 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NPD100841040706-91-9NPD 10084NPD-10084Pyruvate KinaseInhibitorinhibitorinhibit

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