1040706-91-9
1040706-91-9
Chemical Structure
NPD10084
- CAS No.: 1040706-91-9
- Formula:C21H19N3O2
- Molecular Weight:345.39
IUPAC Name: (4-methoxy-1H-indol-2-yl)(1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)methanone
InChIKey: NKLSWHYOKYAGED-UHFFFAOYSA-N
SMILES: COC1=CC=CC2=C1C=C(C(N3CCC4=C(C5=CC=CC=C5N4)C3)=O)N2
Biological Activity: NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and β-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NPD10084 | 99.69% | NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and β-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo. | ||||||||||||||||||||
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Structural Analogs
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Similarity Score 0.62
HY-172969ZHAWOC8655 -
Similarity Score 0.57
HY-120768A-30312 -
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HY-N12316Goshuyuamide I -
Similarity Score 0.55
HY-139822VEGFR-2-IN-10 -
Similarity Score 0.54
HY-120213YH-306 -
Similarity Score 0.54
HY-W715538Rhetsinine -
Similarity Score 0.54
HY-142967TGFβ-IN-1 -
Similarity Score 0.52
HY-16635Setipiprant -
Similarity Score 0.52
HY-119724ABCG2-IN-3 -
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