2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Metabolic Enzyme/Protease Apoptosis
  3. FAK Src PI3K MMP Apoptosis
  4. YH-306

YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization.

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YH-306 Chemical Structure

YH-306 Chemical Structure

CAS No. : 1373764-75-0

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Based on 1 publication(s) in Google Scholar

YH-306 Related Antibodies

Top Publications Citing Use of Products

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Lck

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View All Isoforms
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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Description

YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization[1].

IC50 & Target[1]

PI3K

 

MMP2

 

MMP9

 

Molecular Weight

306.36

Formula

C19H18N2O2
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

OC1=CC=C(C=C1)CC(N2CC(NC3=C4C=CC=C3)=C4CC2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (65.28 mM; ultrasonic and adjust pH to 1 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2641 mL 16.3207 mL 32.6413 mL
5 mM 0.6528 mL 3.2641 mL 6.5283 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2641 mL 16.3207 mL 32.6413 mL 81.6033 mL
5 mM 0.6528 mL 3.2641 mL 6.5283 mL 16.3207 mL
10 mM 0.3264 mL 1.6321 mL 3.2641 mL 8.1603 mL
15 mM 0.2176 mL 1.0880 mL 2.1761 mL 5.4402 mL
20 mM 0.1632 mL 0.8160 mL 1.6321 mL 4.0802 mL
25 mM 0.1306 mL 0.6528 mL 1.3057 mL 3.2641 mL
30 mM 0.1088 mL 0.5440 mL 1.0880 mL 2.7201 mL
40 mM 0.0816 mL 0.4080 mL 0.8160 mL 2.0401 mL
50 mM 0.0653 mL 0.3264 mL 0.6528 mL 1.6321 mL
60 mM 0.0544 mL 0.2720 mL 0.5440 mL 1.3601 mL
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YH-306 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YH-3061373764-75-0YH306YH 306FAKSrcPI3KMMPApoptosisPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinasePhosphoinositide 3-kinaseMatrix metalloproteinasesantitumorcolorectal tumourmigrationinvasionproliferationapoptosisc-SrcRac1Arp2/3Inhibitorinhibitorinhibit

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