YH-306
Based on 1 Customer Validation
YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization.
For research use only. We do not sell to patients.
- Purity: 98.34%
- CAS No.: 1373764-75-0
- Formula: C19H18N2O2
- Molecular Weight:306.36
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
PI3K |
MMP2 |
MMP9 |
Chemical Information
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CAS No. 1373764-75-0
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Appearance Solid
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Molecular Weight 306.36
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Formula C19H18N2O2
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Color Light yellow to light brown
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SMILES
OC1=CC=C(C=C1)CC(N2CC(NC3=C4C=CC=C3)=C4CC2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 20 mg/mL (65.28 mM; ultrasonic and adjust pH to 1 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2641 mL | 16.3207 mL | 32.6413 mL | 81.6033 mL |
| 5 mM | 0.6528 mL | 3.2641 mL | 6.5283 mL | 16.3207 mL | |
| 10 mM | 0.3264 mL | 1.6321 mL | 3.2641 mL | 8.1603 mL | |
| 15 mM | 0.2176 mL | 1.0880 mL | 2.1761 mL | 5.4402 mL | |
| 20 mM | 0.1632 mL | 0.8160 mL | 1.6321 mL | 4.0802 mL | |
| 25 mM | 0.1306 mL | 0.6528 mL | 1.3057 mL | 3.2641 mL | |
| 30 mM | 0.1088 mL | 0.5440 mL | 1.0880 mL | 2.7201 mL | |
| 40 mM | 0.0816 mL | 0.4080 mL | 0.8160 mL | 2.0401 mL | |
| 50 mM | 0.0653 mL | 0.3264 mL | 0.6528 mL | 1.6321 mL | |
| 60 mM | 0.0544 mL | 0.2720 mL | 0.5440 mL | 1.3601 mL |
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