2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Metabolic Enzyme/Protease Apoptosis
  3. FAK Src PI3K MMP Apoptosis
  4. YH-306

YH-306 

Cat. No.: HY-120213 Purity: 98.01%
COA Handling Instructions

YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization.

For research use only. We do not sell to patients.

YH-306 Chemical Structure

YH-306 Chemical Structure

CAS No. : 1373764-75-0

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Based on 1 publication(s) in Google Scholar

YH-306 Related Antibodies

Top Publications Citing Use of Products

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Lck

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View All Isoforms
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

View All MMP Isoform Specific Products:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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Description

YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization[1].

IC50 & Target[1]

PI3K

 

MMP2

 

MMP9

 

Molecular Weight

306.36

Appearance

Solid

Formula

C19H18N2O2
CAS No.
SMILES

OC1=CC=C(C=C1)CC(N2CC(NC3=C4C=CC=C3)=C4CC2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (65.28 mM; ultrasonic and adjust pH to 1 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2641 mL 16.3207 mL 32.6413 mL
5 mM 0.6528 mL 3.2641 mL 6.5283 mL
10 mM 0.3264 mL 1.6321 mL 3.2641 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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YH-306 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

YH-3061373764-75-0YH306YH 306FAKSrcPI3KMMPApoptosisPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinasePhosphoinositide 3-kinaseMatrix metalloproteinasesantitumorcolorectal tumourmigrationinvasionproliferationapoptosisc-SrcRac1Arp2/3Inhibitorinhibitorinhibit

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