1. Protein Tyrosine Kinase/RTK
    PI3K/Akt/mTOR
    Metabolic Enzyme/Protease
    Apoptosis
  2. FAK
    Src
    PI3K
    MMP
    Apoptosis
  3. YH-306

YH-306 

Cat. No.: HY-120213 Purity: 98.01%
Handling Instructions

YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization.

For research use only. We do not sell to patients.

YH-306 Chemical Structure

YH-306 Chemical Structure

CAS No. : 1373764-75-0

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5 mg USD 48 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
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25 mg USD 160 In-stock
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50 mg USD 240 In-stock
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100 mg USD 360 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization[1].

IC50 & Target[1]

PI3K

 

MMP2

 

MMP9

 

Molecular Weight

306.36

Formula

C19H18N2O2

CAS No.
SMILES

OC1=CC=C(C=C1)CC(N2CC(NC3=C4C=CC=C3)=C4CC2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (65.28 mM; ultrasonic and adjust pH to 1 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2641 mL 16.3207 mL 32.6413 mL
5 mM 0.6528 mL 3.2641 mL 6.5283 mL
10 mM 0.3264 mL 1.6321 mL 3.2641 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Product Name:
YH-306
Cat. No.:
HY-120213
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