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Art. -Nr.: HY-142967

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TGFβ-IN-1

TGFβ-IN-1 is an antitumor growth and metastasis agent through inhibiting the transforming growth factor‑β signaling pathway.

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CAS. Nr.: 883560-84-7
Formel: C₁₉H₁₈N₂O
Molecular Weight:290.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

TGFβ-IN-1 Chemical Structure

CAS. Nr.: 883560-84-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

TGFβ-IN-1 is an antitumor growth and metastasis agent through inhibiting the transforming growth factor‑β signaling pathway.

Alle TGF-β Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	<0.5 μM Compound: 8d	Antimigratory activity against human A549 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay Antimigratory activity against human A549 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay	[PMID: 24417479]
A549	IC₅₀	0.1 μM Compound: 8d	Antimigratory activity against human A549 cells assessed as decrease in cell migration after 12 hrs by wound healing assay Antimigratory activity against human A549 cells assessed as decrease in cell migration after 12 hrs by wound healing assay	[PMID: 24417479]
A549	IC₅₀	7.9 μM Compound: 8d	Antiproliferative activity against human A549 cells after 48 hrs by SRB assay Antiproliferative activity against human A549 cells after 48 hrs by SRB assay	[PMID: 24417479]
NCI-H1299	IC₅₀	<0.5 μM Compound: 8d	Antimigratory activity against human H1299 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay Antimigratory activity against human H1299 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay	[PMID: 24417479]
NCI-H1299	IC₅₀	0.1 μM Compound: 8d	Antimigratory activity against human H1299 cells assessed as decrease in cell migration after 12 hrs by wound healing assay Antimigratory activity against human H1299 cells assessed as decrease in cell migration after 12 hrs by wound healing assay	[PMID: 24417479]
NCI-H1299	IC₅₀	8.07 μM Compound: 8d	Antiproliferative activity against human H1299 cells after 48 hrs by SRB assay Antiproliferative activity against human H1299 cells after 48 hrs by SRB assay	[PMID: 24417479]
PC-9	IC₅₀	5.87 μM Compound: 8d	Antiproliferative activity against human PC9 cells after 48 hrs by SRB assay Antiproliferative activity against human PC9 cells after 48 hrs by SRB assay	[PMID: 24417479]

Chemical Information

CAS. Nr. 883560-84-7
Molecular Weight 290.36
Formel C₁₉H₁₈N₂O
SMILES

O=C(N(C1)CCC2=C1NC3=C2C=CC=C3)CC4=CC=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zheng C, et al. Synthesis and biological evaluation of novel tetrahydro-β-carboline derivatives as antitumor growth and metastasis agents through inhibiting the transforming growth factor-β signaling pathway. J Med Chem. 2014 Feb 13;57(3):600-12. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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