country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-142967

Copy Link Print Information

TGFβ-IN-1

TGFβ-IN-1 is an antitumor growth and metastasis agent through inhibiting the transforming growth factor‑β signaling pathway.

For research use only. We do not sell to patients.

CAS No.: 883560-84-7
Formula: C₁₉H₁₈N₂O
Molecular Weight:290.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

TGFβ-IN-1 Chemical Structure

CAS No.: 883560-84-7

Size

Price

Stock

Quantity

Sample (0.1mg)

In-stock

(In Japan)

Apply Now

Get Quote Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability Get Quote Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability

Bulk Inquiry

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

TGFβ-IN-1 is an antitumor growth and metastasis agent through inhibiting the transforming growth factor‑β signaling pathway.

All TGF-β Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	<0.5 μM Compound: 8d	Antimigratory activity against human A549 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay Antimigratory activity against human A549 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay	[PMID: 24417479]
A549	IC₅₀	0.1 μM Compound: 8d	Antimigratory activity against human A549 cells assessed as decrease in cell migration after 12 hrs by wound healing assay Antimigratory activity against human A549 cells assessed as decrease in cell migration after 12 hrs by wound healing assay	[PMID: 24417479]
A549	IC₅₀	7.9 μM Compound: 8d	Antiproliferative activity against human A549 cells after 48 hrs by SRB assay Antiproliferative activity against human A549 cells after 48 hrs by SRB assay	[PMID: 24417479]
NCI-H1299	IC₅₀	<0.5 μM Compound: 8d	Antimigratory activity against human H1299 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay Antimigratory activity against human H1299 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay	[PMID: 24417479]
NCI-H1299	IC₅₀	0.1 μM Compound: 8d	Antimigratory activity against human H1299 cells assessed as decrease in cell migration after 12 hrs by wound healing assay Antimigratory activity against human H1299 cells assessed as decrease in cell migration after 12 hrs by wound healing assay	[PMID: 24417479]
NCI-H1299	IC₅₀	8.07 μM Compound: 8d	Antiproliferative activity against human H1299 cells after 48 hrs by SRB assay Antiproliferative activity against human H1299 cells after 48 hrs by SRB assay	[PMID: 24417479]
PC-9	IC₅₀	5.87 μM Compound: 8d	Antiproliferative activity against human PC9 cells after 48 hrs by SRB assay Antiproliferative activity against human PC9 cells after 48 hrs by SRB assay	[PMID: 24417479]

Chemical Information

CAS No. 883560-84-7
Molecular Weight 290.36
Formula C₁₉H₁₈N₂O
SMILES

O=C(N(C1)CCC2=C1NC3=C2C=CC=C3)CC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zheng C, et al. Synthesis and biological evaluation of novel tetrahydro-β-carboline derivatives as antitumor growth and metastasis agents through inhibiting the transforming growth factor-β signaling pathway. J Med Chem. 2014 Feb 13;57(3):600-12. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock

Price: USD 0.00

Biological Activity
- Description
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity: